Oligonucleotide News and Research

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Using Single-Molecule Studies to Understand Cellular Processes: An Interview with Professor W. E. Moerner

Single fluorescent molecules provide a local nanometer-sized probe of complex systems. We can measure the motion of the single molecule, use them to achieve imaging on a scale down to 20 nanometers, or we can infer aspects of the behaviour of the object under study by the details of the light that is emitted.

From Pittcon 26 Jan 2016

Novel drug shows promise against metastatic breast cancer in mouse models

12 Jan 2016

Novel drug shows promise in mouse models of human metastatic breast cancer

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character - from aggressive to static, and no longer shedding cells that can colonize distant organs of the body. Indeed, most patients with breast and other forms of cancer who succumb to the illness do so because of the cancer's unstoppable spread.

23 Dec 2015

Regulus begins RG-125(AZD4076) Phase I study for treatment of NASH in patients with type 2 diabetes/pre-diabetes

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today that dosing has begun in a first-in-human Phase I clinical study of RG-125(AZD4076), by its collaboration partner AstraZeneca.

21 Dec 2015

Researchers find new way to prevent or reduce pathologies caused by malformed proteins

Improperly formed proteins can cause a host of serious illnesses, from muscular dystrophy to cystic fibrosis. A question of enormous import in research, beyond the challenge of determining how malformed proteins contribute to specific disease processes, is figuring out ways to prevent or reduce the pathologies they cause.

16 Dec 2015

Study paves way for development of novel cancer therapeutics

A team of scientists, comprising researchers from the Institute of Molecular and Cell Biology, a research institute under the Agency for Science, Technology and Research, Singapore, and the VIB Laboratory of Molecular Cancer Biology, has revealed the mechanism by which tumor cells elevate levels of MDM4, a protein that is highly expressed in cancer cells but not in normal adult tissues.

16 Dec 2015

Research reveals MECP2 Duplication Syndrome can be reversed

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett Syndrome while gene duplication causing over-expression lead to MECP2 Duplication Syndrome. Both disorders are severely debilitating childhood neurological diseases.

26 Nov 2015

Researchers identify molecular switch that can convert unhealthy white fat into energy-burning brown fat

A research team led by UC San Francisco scientists has identified a molecular switch capable of converting unhealthy white fat into healthy, energy-burning brown fat in mice. Drugs that flip this switch rapidly reduced obesity and diabetes risk factors in mice fed a high fat diet.

30 Oct 2015

IDT’s innovative Alt-R CRISPR-Cas9 System improves genome editing potency, reduces cell toxicity

Integrated DNA Technologies, introduces a new approach to CRISPR—its innovative Alt-R CRISPR-Cas9 System, based on the naturally occurring S. pyogenes CRISPR RNA system.

From Integrated DNA Technologies 29 Oct 2015

Sense oligonucleotide antidote reverses actions of antisense antithrombotic drug, prevents bleeding

Researchers from Isis Pharmaceuticals (Carlsbad, CA) and Prysis Biotechnologies (Pudong, Shanghai, China) have demonstrated proof-of-concept for using a sense oligonucleotide to undo the effects of an antisense drug, an antithrombotic agent in this novel study.

14 Oct 2015

Study: RNA editing technique shows promise in treating rare, severe form of muscular dystrophy

An RNA editing technique called "exon skipping" has shown preliminary success in treating a rare and severe form of muscular dystrophy that currently has no treatment, based on a new study from Northwestern Medicine and the University of Chicago. Children with the disease lose significant muscle strength early in life.

13 Oct 2015

Researchers develop chip-based instrument for reliable detection of Ebola virus

A team led by researchers at UC Santa Cruz has developed chip-based technology for reliable detection of Ebola virus and other viral pathogens. The system uses direct optical detection of viral molecules and can be integrated into a simple, portable instrument for use in field situations where rapid, accurate detection of Ebola infections is needed to control outbreaks.

25 Sep 2015

Scientists elucidate genetic interaction that may prove key to development, progression of glaucoma

Scientists at the University of California, San Diego School of Medicine have elucidated a genetic interaction that may prove key to the development and progression of glaucoma, a blinding neurodegenerative disease that affects tens of millions of people worldwide and is a leading cause of irreversible blindness.

11 Sep 2015

Dr Tavormina wins IDT award for global warming and methane sinks research

Integrated DNA Technologies (IDT), the world leader in custom oligonucleotide synthesis, awarded the inaugural IDT ISO 14001 Sustainability Award to Dr Patricia Tavormina of the Division of Geological and Planetary Sciences at the California Institute of Technology. Dr Tavormina's research focuses on naturally occurring methane-oxidizing bacteria (MOB), and the role they play in limiting greenhouse gases, which contribute to global warming.

From Integrated DNA Technologies 10 Sep 2015

IDT to host webinar on high throughput qPCR profiling studies

Integrated DNA Technologies will be hosting a webinar to help researchers get the most out of gene expression studies that analyze large numbers of samples.

From Integrated DNA Technologies 4 Sep 2015

Common gene mutation may cause brain damage associated with ALS and FTD

Johns Hopkins researchers say they have discovered some of the first steps in how a very common gene mutation causes the brain damage associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

27 Aug 2015

IDT webinar explores effective RNAi and antisense oligo methods

Integrated DNA Technologies (IDT) will host an informative webinar, entitled ‘Knockdown of lncRNAs: exploring RNAi and antisense oligo methods’, on Tuesday, August 25, 2015. Kim Lennox, a research scientist at IDT and expert in the suppression of gene expression, will present the webinar at 9 am and 1 pm Central Standard Time.

From Integrated DNA Technologies 19 Aug 2015

Oligonucleotide News and Research

Using Single-Molecule Studies to Understand Cellular Processes: An Interview with Professor W. E. Moerner

Novel drug shows promise against metastatic breast cancer in mouse models

Novel drug shows promise in mouse models of human metastatic breast cancer

Regulus begins RG-125(AZD4076) Phase I study for treatment of NASH in patients with type 2 diabetes/pre-diabetes

Researchers find new way to prevent or reduce pathologies caused by malformed proteins

Study paves way for development of novel cancer therapeutics

Research reveals MECP2 Duplication Syndrome can be reversed

Researchers identify molecular switch that can convert unhealthy white fat into energy-burning brown fat

IDT’s innovative Alt-R CRISPR-Cas9 System improves genome editing potency, reduces cell toxicity

Sense oligonucleotide antidote reverses actions of antisense antithrombotic drug, prevents bleeding

Study: RNA editing technique shows promise in treating rare, severe form of muscular dystrophy

Researchers develop chip-based instrument for reliable detection of Ebola virus

Scientists elucidate genetic interaction that may prove key to development, progression of glaucoma

Dr Tavormina wins IDT award for global warming and methane sinks research

IDT to host webinar on high throughput qPCR profiling studies

Common gene mutation may cause brain damage associated with ALS and FTD

IDT webinar explores effective RNAi and antisense oligo methods

Isis Pharmaceuticals, AstraZeneca to develop antisense therapies for cardiovascular, metabolic, renal diseases

Trends, R&D progress, and predicted revenues in RNAi therapies

IDT’s fully licensed MGB Eclipse qPCR probes available for online ordering

Industry Focus eBook - Protein Analysis (3rd edition) eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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