Phosphorylation News and Research

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Long COVID may be due to persistent immune disturbances

A new study discusses abnormalities in the immune response following COVID-19 in samples collected from patients who have recovered from COVID-19.

8 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Treating mice that have a Parkinson's disease-causing mutation with a small molecule compound restores the removal of damaged mitochondria from their brain cells, shows a study published today in eLife.

3 Aug 2021

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

Oncotarget published "Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells" which reported that retinoic acid is a fundamental regulator of cell cycle and cell differentiation.

28 Jul 2021

Clinical trials during a pandemic – lessons from COVID-19

In this interview, Dr. Benedicte Roquebert, Dr. Stephanie Haim-Boukobza and Dr. Souad Mehlal discuss how COVID-19 has resulted in new ways to think about clinical trials during a pandemic.

From Cerba Research 23 Jul 2021

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

The investigational therapeutic ficlatuzumab in combination with chemotherapy showed signs of clinical efficacy in patients with relapsed/refractory acute myeloid leukemia.

16 Jul 2021

Mass spectrometry: An important tool to unravel mechanisms underlying Huntington's disease

Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington's disease (HD), alongside the increased availability of cell and animal models of the disease.

14 Jul 2021

First synthetic circuit consists of entirely fast, reversible protein-protein interactions

Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.

7 Jul 2021

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease.

29 Jun 2021

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

A new study describes the varying ways in which the virus co-opts the machinery of the host cell following infection to evade or modulate the host immune response, alter the pattern of translation of viral proteins, and the release of new viral particles.

24 Jun 2021

SARS-CoV N protein elicits production of IFN-β by provoking ubiquitination of RIG-I, finds study

A recent study published in Frontiers in Immunology focuses on the roles of the SADS-CoV N protein in IFN suppression during infection.

23 Jun 2021

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

A new class of drugs that inhibits a "master switch" involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin's lymphoma, has been discovered by researchers at Mount Sinai.

22 Jun 2021

Unrepaired DNA damage can increase the speed of aging, study suggests

Every day, our bodies face a bombardment of UV rays, ozone, cigarette smoke, industrial chemicals and other hazards.

21 Jun 2021

New methods may lead to optimal treatment for lung cancer

Today as they did 100 years ago, doctors diagnose cancer by taking tissue samples from patients, which they usually fix in formalin for microscopic examination.

18 Jun 2021

Study creates a new model of Alzheimer's disease progression

Alzheimer's disease is the most common form of dementia and is characterized by neurodegeneration in regions of the brain involved in memory and learning. Amyloid beta and tau are two toxic proteins that build up in disease and cause eventual neuronal death, but little is known about how other cells in the brain react during disease progression.

14 Jun 2021

Forkhead box O's potential therapeutic use in the treatment of COVID-19

In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease).

13 Jun 2021

How SARS-CoV-2 variant B.1.1.7 adapted to evade innate immunity

Researchers in the United States and the UK have conducted a study showing how the B.1.1.7 (Alpha) lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adapted to suppress host innate immune responses in lung epithelial cells.

8 Jun 2021

Could the intranasal route be an alternate avenue of COVID-19 vaccination?

A new study has been published in the journal Vaccines that summarizes the history of vaccines, reviews the current progress in COVID-19 vaccine technology, and discusses the status of intranasal COVID-19 vaccines as a potential pathway to immunization.

8 Jun 2021

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions.

8 Jun 2021

Study uncovers novel molecular mechanism of immune cell migration

In a new study, researchers from Osaka University discovered a novel molecular mechanism by which immune cells migrate to fight off infections. These findings may help in understanding the development of certain immune deficiency disorders and establish novel therapies against them.

7 Jun 2021

Phosphorylation News and Research

Long COVID may be due to persistent immune disturbances

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

Clinical trials during a pandemic – lessons from COVID-19

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

Mass spectrometry: An important tool to unravel mechanisms underlying Huntington's disease

First synthetic circuit consists of entirely fast, reversible protein-protein interactions

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

SARS-CoV N protein elicits production of IFN-β by provoking ubiquitination of RIG-I, finds study

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

Unrepaired DNA damage can increase the speed of aging, study suggests

New methods may lead to optimal treatment for lung cancer

Study creates a new model of Alzheimer's disease progression

Forkhead box O's potential therapeutic use in the treatment of COVID-19

How SARS-CoV-2 variant B.1.1.7 adapted to evade innate immunity

Could the intranasal route be an alternate avenue of COVID-19 vaccination?

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Study uncovers novel molecular mechanism of immune cell migration

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