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Novel laboratory model may shine light on development of pediatric high-grade glioma

Pediatric high-grade glioma is the primary cause of cancer death in children. Genesis of these tumors is believed to be driven by mutations in proteins that disrupt fundamental mechanisms governing the development of the human brain.

27 Oct 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

Research advance may lead to preservation of hearing in people with Usher syndrome type III

A research advance co-led by Case Western Reserve University School of Medicine's Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory "hair" cells in the inner ear. USH3 is caused by a mutation in the clarin-1 gene.

26 Oct 2017

Penn study sheds light on genetic cause of early hearing loss

From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing.

26 Oct 2017

Single infusion of wildtype HSPCs halts cellular damage caused by neuromuscular disorder in mice

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

25 Oct 2017

Researchers map molecular events that direct cells' energy metabolism down the cancerous path

As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells.

24 Oct 2017

Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma.

23 Oct 2017

Study identifies predictors of poor outcomes in Duchenne muscular dystrophy patients

A new study from UT Southwestern suggests that more people with Duchenne muscular dystrophy could live longer by identifying and more aggressively treating patients with certain risk factors.

20 Oct 2017

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in cells of the immune system could be a strategy to treat inflammatory lung disease.

20 Oct 2017

Researchers reveal how certain nerves sustain prostate cancer growth

In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to proliferate.

20 Oct 2017

New research provides insights into role of key cancer gene

New research represents a promising step towards better understanding of a key cancer gene. A long-running collaboration between researchers at the Babraham Institute, Cambridge, and the AstraZeneca IMED Biotech Unit reveals new insights into how the PTEN gene may control cell growth and behavior and how its loss contributes to the development and advancement of certain cancers.

19 Oct 2017

New imaging system offers better way to monitor brain changes from Alzheimer's in mouse models

An estimated 5.5 million Americans live with Alzheimer's disease, a type of dementia that causes problems with memory, thinking and behavior. Although treatments can slow the worsening of symptoms, scientists are still working to better understand the neurodegenerative disease so that curative and preventative medicines can be developed.

17 Oct 2017

Study opens door to new approach for curing HIV infections

In findings that open the door to a completely different approach to curing HIV infections, scientists from the Florida campus of The Scripps Research Institute have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells, and prevents viral rebound, even when those infected cells are subjected to vigorous stimulation.

17 Oct 2017

UAB researchers report major advance in efforts to repair damaged heart after heart attack

University of Alabama at Birmingham biomedical engineers report a significant advance in efforts to repair a damaged heart after a heart attack, using grafted heart-muscle cells to create a repair patch.

17 Oct 2017

Study sheds new light on why autism is more common in boys

Researchers aiming to understand why autism spectrum disorders (ASD) are more common in boys have discovered differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism-causing genetic glitch.

17 Oct 2017

Findings reveal how seizures can have lasting detrimental effects on memory

Although it's been clear that seizures are linked to memory loss and other cognitive deficits in patients with Alzheimer's disease, how this happens has been puzzling. In a study published in the journal Nature Medicine, a team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.

16 Oct 2017

Einstein scientists share $9 million NIH grant for longevity research

Scientists now believe that the Fountain of Youth flows from our genes, or at least from the genes of people who live healthy lives to age 100 or later.

16 Oct 2017

Investigating new cancer therapy candidates with live-cell imaging

There are two main things that we've worked on in the lab as regards to drug studies. One is identifying new combinations of drugs, and working on why a combination of drugs should work better than each alone.

From Sartorius 16 Oct 2017

Study reveals unique norovirus characteristic of hiding from host immune system

Noroviruses are the leading cause of non-bacterial gastroenteritis in the world and are estimated to cause 267 million infections and 20,000 deaths each year. This virus causes severe diarrhea, nausea, and stomach pain.

11 Oct 2017

Allergy medication restores nervous system function in patients with chronic MS

In a remarkably rapid translation of laboratory research findings into a treatment with the potential to benefit patients, UC San Francisco scientists have successfully completed a Phase II clinical trial showing that an FDA-approved antihistamine restores nervous system function in patients with chronic multiple sclerosis (MS).

11 Oct 2017

Mouse Model News and Research

Novel laboratory model may shine light on development of pediatric high-grade glioma

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

Research advance may lead to preservation of hearing in people with Usher syndrome type III

Penn study sheds light on genetic cause of early hearing loss

Single infusion of wildtype HSPCs halts cellular damage caused by neuromuscular disorder in mice

Researchers map molecular events that direct cells' energy metabolism down the cancerous path

Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Study identifies predictors of poor outcomes in Duchenne muscular dystrophy patients

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

Researchers reveal how certain nerves sustain prostate cancer growth

New research provides insights into role of key cancer gene

New imaging system offers better way to monitor brain changes from Alzheimer's in mouse models

Study opens door to new approach for curing HIV infections

UAB researchers report major advance in efforts to repair damaged heart after heart attack

Study sheds new light on why autism is more common in boys

Findings reveal how seizures can have lasting detrimental effects on memory

Einstein scientists share $9 million NIH grant for longevity research

Investigating new cancer therapy candidates with live-cell imaging

Study reveals unique norovirus characteristic of hiding from host immune system

Allergy medication restores nervous system function in patients with chronic MS

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