Protein C News and Research

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Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer's into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before.

5 Mar 2014

Experimental drug nivolumab shrinks tumors in patients with advanced melanoma

An experimental drug aimed at restoring the immune system's ability to spot and attack cancer halted cancer progression or shrank tumors in patients with advanced melanoma, according to a multisite, early-phase clinical trial at Johns Hopkins Kimmel Cancer Center and 11 other institutions. All patients had experienced disease progression despite prior systemic therapies, and most had received two or more prior treatments.

4 Mar 2014

Bruker opens new preclinical imaging center of excellence for the Americas

Bruker (NASDAQ: BRKR) today announced the official opening of a new Preclinical Imaging Center of Excellence for the Americas in Billerica, Massachusetts. The facility offers advanced development, demonstration and support facilities for Bruker’s industry-leading portfolio of preclinical imaging instrumentation and multimodal platforms.

4 Mar 2014

Beckman Coulter Life Sciences announces agreement with Wyatt Technology Corporation

Beckman Coulter Life Sciences today announced an agreement with Wyatt Technology Corporation enabling collaboration on products, applications and technical development. The partnership brings together Wyatt’s expertise in protein characterization, light scattering and biophysics with Beckman Coulter’s expertise in particle counting, particle characterization and cell viability measurement.

4 Mar 2014

GTx provides clinical updates, reports financial results for fourth quarter and full year 2013

GTx, Inc. today provided a Company update and reported financial results for the fourth quarter and full year 2013.

4 Mar 2014

Procellera technology enhances cell migration in in-vitro laboratory testing

Procellera – the world's first wireless microcurrent generating dressing that produces electrical fields through its matrix of microcell batteries – was found to significantly enhance cell migration in in-vitro laboratory testing, according to groundbreaking research led by The Ohio State University Wexner Medical Center Professor Chandan K. Sen. Professor Sen is also the Director of the Comprehensive Wound Center at Ohio State.

4 Mar 2014

Drug that unleashes immune system can produce lasting remissions in patients with melanoma

A drug that unleashes the immune system to attack cancer can produce lasting remissions and hold the disease in check - for more than two years, in some cases - in many patients with advanced melanoma, according to a new study by researchers at Dana-Farber Cancer Institute, Johns Hopkins University, Yale University, and allied institutions.

4 Mar 2014

Blocking myoferlin gene can reduce breast cancer cell migration

New research suggests that a protein only recently linked to cancer has a significant effect on the risk that breast cancer will spread, and that lowering the protein's level in cell cultures and mice reduces chances for the disease to extend beyond the initial tumor.

4 Mar 2014

Researchers identify drug using yeast model that reduces levels of toxic protein in brains of AD patients

Using a yeast model of Alzheimer's disease (AD), Whitehead Institute researchers have identified a drug that reduces levels of the toxic protein fragment amyloid-β (Aβ) and prevents at least some of the cellular damage caused when Aβ accumulates in the brains of AD patients.

4 Mar 2014

Research discovery advances efforts to replace damaged heart muscle

In a study that began in a pair of infant siblings with a rare heart defect, Johns Hopkins researchers say they have identified a key molecular switch that regulates heart cell division and normally turns the process off around the time of birth. Their research, they report, could advance efforts to turn the process back on and regenerate heart tissue damaged by heart attacks or disease.

4 Mar 2014

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation.

4 Mar 2014

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Researchers at NYU Langone Medical Center have found that blocking the action of a key signaling molecule in the immune system known as Netrin-1 stalls chronic inflammation and insulin resistance tied to obesity and often derived from fatty diets.

4 Mar 2014

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

New research from Memorial Sloan Kettering provides fresh insight into the biologic mechanisms that individual cancer cells use to metastasize to the brain.

4 Mar 2014

Scientists report major step forward in determining specific behavior of PP1 enzyme

In the Proceedings of the National Academy of Sciences, a team of scientists at Brown University reports a major step forward in determining the specific behavior of the ubiquitous enzyme PP1 implicated in a wide range of diseases including cancer.

4 Mar 2014

New research uncovers abnormal molecular signaling pathways for kidney failure

Prevention and reversal of chronic kidney disease is an urgent public health need. The disease affects 1 in 10 Americans, is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure.

4 Mar 2014

3-D imaging of two different mouse models helps understand Apert Syndrome development

Three dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans.

4 Mar 2014

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills.

4 Mar 2014

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

OPKO Health, Inc., a multi-national biopharmaceutical and diagnostics company, today reported operating and financial results for its 2013 fourth quarter and full year ended December 31, 2013.

4 Mar 2014

Research explores milk proteins for healthy aging and sports performance

The University of Limerick will take the lead in Phase 2 of Food for Health Ireland’s research programme to explore the role of milk proteins in healthy aging and performance nutrition.

4 Mar 2014

Atopix presents positive results of Phase IIb asthma study at AAAAI meeting

Atopix Therapeutics Ltd ("Atopix"), a biopharmaceutical company developing innovative CRTH2 antagonists for allergic disease, announced the results of a Phase IIb asthma study with their lead compound OC459 at the American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting , San Diego, California, USA on March 1st.

3 Mar 2014

Protein C News and Research

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Experimental drug nivolumab shrinks tumors in patients with advanced melanoma

Bruker opens new preclinical imaging center of excellence for the Americas

Beckman Coulter Life Sciences announces agreement with Wyatt Technology Corporation

GTx provides clinical updates, reports financial results for fourth quarter and full year 2013

Procellera technology enhances cell migration in in-vitro laboratory testing

Drug that unleashes immune system can produce lasting remissions in patients with melanoma

Blocking myoferlin gene can reduce breast cancer cell migration

Researchers identify drug using yeast model that reduces levels of toxic protein in brains of AD patients

Research discovery advances efforts to replace damaged heart muscle

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

Scientists report major step forward in determining specific behavior of PP1 enzyme

New research uncovers abnormal molecular signaling pathways for kidney failure

3-D imaging of two different mouse models helps understand Apert Syndrome development

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

Research explores milk proteins for healthy aging and sports performance

Atopix presents positive results of Phase IIb asthma study at AAAAI meeting

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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