Antigen News and Research

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Clonally expanded plasma cell lineages in SARS-CoV-2 produce specific neutralizing antibodies

A new preprint research paper posted to the bioRxiv server provides a greater understanding of the aspect of humoral immunity against the virus – the plasma cells that pour out a flood of specific antibodies targeting various epitopes on the pathogen.

16 Feb 2021

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

In the study, published on the preprint server bioRxiv, the team evaluated the ability of AS03, CpG 1018 formulated in Alum, the TLR-7 agonist adsorbed to Alum (AS37), the squalene-in-water emulsion (O/W), and Alum to boost protective immunity against SARS-CoV-2.

15 Feb 2021

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

A new preprint research paper posted to the bioRxiv server demonstrates the potential of using the pre-existing protective responses to produce a broad-spectrum neutralizing response against not just SARS-CoV-2 but other future pathogens.

14 Feb 2021

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

14 Feb 2021

LMU researchers study T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

13 Feb 2021

Scent detection dogs can be used to screen and identify COVID-19-infected individuals

In a recent article in the Journal of Osteopathic Medicine, authors gathered previously published research to summarize current thinking on the feasibility and efficacy of using scent detection dogs to screen for the COVID-19 virus.

11 Feb 2021

STING activation may be a new approach to reduce graft-versus-host disease

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD).

11 Feb 2021

New urine test could avoid unnecessary prostate cancer biopsies

A urine test based on University of Michigan Rogel Cancer Center research could have avoided one third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients.

11 Feb 2021

Genomic test may help guide treatment decisions for patients with recurrent prostate cancer

A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research from the Johns Hopkins Kimmel Cancer Center and 15 other medical centers.

11 Feb 2021

COVID-19 immunity study to enroll college students to test vaccine effectiveness

A University of Arizona Health Sciences study that is examining COVID-19 immunity and re-infection among frontline workers is expanding to include some Arizona college students while broadening its research focus to include COVID-19 vaccination effectiveness.

11 Feb 2021

Second dose of Pfizer-BioNTech COVID-19 vaccine may not benefit previously infected individuals

Researchers at the NYU Grossman School of Medicine have shown that a second dose of the Pfizer-BioNTech BNT162b2 vaccine may not offer any additional protection against coronavirus disease 2019 (COVID-19) over one dose among individuals previously infected with the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

10 Feb 2021

Freiburg immunologists decipher anti-cancer drug's mode of operation

Rituximab, an anti-cancer drug targeting the membrane protein CD20, was the first approved therapeutic antibody against B tumor cells. Immunologists at the University of Freiburg have now solved a mystery about how it works.

10 Feb 2021

Researchers identify top-performing COVID-19 POC tests

After screening more than 1,100 independently assessed, point-of-care COVID-19 tests, researchers at NSF International and Novateur Ventures have identified 5 direct (antigen/RNA) tests for detection of acute infection and 6 indirect (antibody) tests for detection of prior infection that meet the recently published World Health Organization (WHO) "desirable" Target Product Profile (TPP) criteria.

10 Feb 2021

Polyclonal SARS-CoV-2 antibody shows potent neutralizing activity in vitro

Researchers shows a fully human immunoglobulin (IgG) that potently inhibits SARS-CoV-2 infection.

10 Feb 2021

Researchers develop self-assembling nanoparticle SARS-CoV-2 vaccines

Researchers in China have developed three SARS-CoV-2 nanoparticle vaccines, containing receptor-binding domain (RBD) trimer, S1 trimer, and ectodomain (ECD) trimer, respectively. To do this, they have used Ferritin nanoparticle self-assembly technology.

9 Feb 2021

Smell and taste loss symptoms associated with robust SARS-CoV-2 antibody response in new study

Researchers in Italy report a correlation between the loss of smell and taste and an observed persistence or rise in antibody levels at five months after infection.

9 Feb 2021

Vaccinated mothers may pass on SARS-CoV-2 antibodies to newborns

A new study describes the first case of anti-SARS-CoV-2 antibodies detected in the cord blood of an infant born to a mother immunized with the first dose of an mRNA COVID-19 vaccine three weeks earlier.

9 Feb 2021

New book highlights need for rapid, frequent screening to control the pandemic

Covid-19 is a global pandemic inflicting large health and economic costs. In his previous book, The Pandemic Information Gap: The Brutal Economics of COVID-19 (The MIT Press, 2020), economist Joshua Gans explains that those costs have been so large because governments and others have lacked the information needed to control the pandemic.

9 Feb 2021

4th preclinical study for Novavax in non-human primates, tests SARS-CoV-2 variants

Researchers in the United States have identified specific immune correlates that might be key to ensuring that vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protects against not only disease, but also viral transmission and emerging variants.

8 Feb 2021

Study shows efficacy of radionuclide therapy–immunotherapy combination in prostate cancer model

A combination of radionuclide therapy and immunotherapy has proven successful in slowing the progression of prostate cancer and increasing survival time, according to new research published in the February issue of The Journal of Nuclear Medicine.

8 Feb 2021

Antigen News and Research

Clonally expanded plasma cell lineages in SARS-CoV-2 produce specific neutralizing antibodies

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

LMU researchers study T cell exhaustion

Scent detection dogs can be used to screen and identify COVID-19-infected individuals

STING activation may be a new approach to reduce graft-versus-host disease

New urine test could avoid unnecessary prostate cancer biopsies

Genomic test may help guide treatment decisions for patients with recurrent prostate cancer

COVID-19 immunity study to enroll college students to test vaccine effectiveness

Second dose of Pfizer-BioNTech COVID-19 vaccine may not benefit previously infected individuals

Freiburg immunologists decipher anti-cancer drug's mode of operation

Researchers identify top-performing COVID-19 POC tests

Polyclonal SARS-CoV-2 antibody shows potent neutralizing activity in vitro

Researchers develop self-assembling nanoparticle SARS-CoV-2 vaccines

Smell and taste loss symptoms associated with robust SARS-CoV-2 antibody response in new study

Vaccinated mothers may pass on SARS-CoV-2 antibodies to newborns

New book highlights need for rapid, frequent screening to control the pandemic

4th preclinical study for Novavax in non-human primates, tests SARS-CoV-2 variants

Study shows efficacy of radionuclide therapy–immunotherapy combination in prostate cancer model

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