Cell Death News and Research

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Aspirin may inhibit the growth of mesothelioma, shows study

Aspirin may inhibit the growth of mesothelioma, an aggressive and deadly asbestos-related cancer, University of Hawai'i Cancer Center researchers have found.

7 Jul 2015

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Peripheral nerve injuries often are caused by trauma or surgical complications and can result in considerable disabilities. Regeneration of peripheral nerves can be accomplished effectively using autologous (self-donated) nerve grafts, but that procedure may sacrifice a functional nerve and cause loss of sensation in another part of the patient's body.

7 Jul 2015

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Investigators have discovered the precise molecular steps that enable immune cells implicated in certain forms of asthma and allergy to develop and survive in the body. The findings from Weill Cornell Medical College reveal a new pathway that scientists could use to develop more effective treatments and therapies for the chronic lung disorder.

7 Jul 2015

New therapeutic alternative found for children suffering from Ewing's sarcoma

A research consortium made up of the Virgen del Rocio hospital in Seville, Sant Joan de Deu and the Bellvitge Biomedical Research Institute in Barcelona, has found a new therapeutic alternative for children who suffer from a malignant pediatric tumor bone and soft tissue called Ewing's sarcoma.

7 Jul 2015

New research suggests that Bcl-Rambo protein can protect against heart failure

A protein dubbed 'Bcl-Rambo' can protect against heart failure, suggests new research from King's College London and funded by the British Heart Foundation.

7 Jul 2015

Imaging proteasome complex helps show target site for potential cancer drugs

Scientists have pioneered the use of a high-powered imaging technique to picture in exquisite detail one of the central proteins of life - a cellular recycling unit with a role in many diseases.

3 Jul 2015

Research shows how prion-like proteins critical for maintaining long-term memories

Research from Eric Kandel's lab at Columbia University Medical Center has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.

3 Jul 2015

Review article provides in depth survey of studies focusing on retinoblastoma protein's role in apoptosis

Retinoblastoma protein RB1, which is named after a form of pediatric tumor of the eye, is among the most common genetically regulated cellular proteins to malfunction in human cancer. RB1 was also the first tumor suppressor gene to be identified and its modes of inactivation in retinoblastoma tumors provided the basis for the ground-breaking two-hit hypothesis by the geneticist Alfred G. Knudson in the 70s, according to which cancer is due to the accumulation of multiple 'hits' or mutations in certain genes.

3 Jul 2015

Bacterial ‘fight club’ approach effective for finding new drugs from natural sources

Creating bacterial "fight clubs" is an effective way to find new drugs from natural sources. That is the conclusion of a team of Vanderbilt chemists who have been exploring ways to get bacteria to produce biologically active chemicals that they normally hold in reserve. These compounds are called secondary metabolites.

30 Jun 2015

Discovery sheds light on how the Hippo pathway maintains cellular balance

Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.

27 Jun 2015

Small intestine causes chronic inflammation in obese patients

Obesity is caused by numerous and complex factors, some of which are as yet unsuspected. Scientists from the CNRS, INSERM, UPMC and Université Paris Descartes, working with research clinicians from Paris Public Hospitals (AP-HP) have now shown that severe obesity is accompanied by inflammation of the small intestine and enhanced immune response in that region.

22 Jun 2015

Drug discovery experts receive £3m to find new treatments for Alzheimer's disease

Funding worth nearly half a million pounds will unite academics at the University of Southampton with drug discovery experts at the medical research charity MRC Technology, to target the immune system in the hunt for new treatments for Alzheimer's disease.

19 Jun 2015

Researchers find easy way to produce carbon nanoparticles that can carry drugs to targeted tissues

Researchers have found an easy way to produce carbon nanoparticles that are small enough to evade the body's immune system, reflect light in the near-infrared range for easy detection, and carry payloads of pharmaceutical drugs to targeted tissues.

19 Jun 2015

Researchers explore the science of exosomes in heart repair

A little more than a decade ago, researchers discovered that all cells secrete tiny communications modules jammed with an entire work crew of messages for other cells. Today, a team of researchers, led by stem cell researcher Raj Kishore, PhD, Director of the Stem Cell Therapy Program at the Center for Translational Medicine at Temple University School of Medicine, is harnessing the communications vesicles excreted by stem cells and using them to induce the damaged heart to repair itself.

19 Jun 2015

MGH researchers develop new approach to skin rejuvenation

A new approach to skin rejuvenation developed at Massachusetts General Hospital (MGH) may be less likely to have unintended side effects such as scarring and altered pigmentation.

18 Jun 2015

RPCI receives NCI grant to continue research program on photodynamic therapy for head and neck cancers

Roswell Park Cancer Institute has received continuation of a prestigious program project grant from the National Cancer Institute for research through the Roswell Park Photodynamic Therapy Center.

17 Jun 2015

Fruit flies helping FAU researchers to discover novel genes responsible for neuroprotection

They're pesky and annoying when they get into your fruit, but Drosophila melanogaster, more affectionately known as the "fruit fly," are helping researchers at Florida Atlantic University to discover novel genes that are responsible for neuroprotection.

17 Jun 2015

DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

16 Jun 2015

α-synuclein conformation may underlie neurodegenerative variability

Varying structural conformations of α-synuclein may explain how one protein can give rise to distinct forms of neurodegeneration, say researchers.

12 Jun 2015

Daily dose of aspirin effective at blocking breast tumor growth

"Take two aspirin and call me in the morning" has been the punchline for countless jokes. Could it also be good advice for cancer patients? A lab study to appear in the July 2015 issue of Laboratory Investigation found that a daily dose of aspirin was effective at blocking breast tumor growth. Previous studies have already shown a similar effect on colon, gastrointestinal, prostate, and other cancers.

12 Jun 2015

Cell Death News and Research

Aspirin may inhibit the growth of mesothelioma, shows study

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

New therapeutic alternative found for children suffering from Ewing's sarcoma

New research suggests that Bcl-Rambo protein can protect against heart failure

Imaging proteasome complex helps show target site for potential cancer drugs

Research shows how prion-like proteins critical for maintaining long-term memories

Review article provides in depth survey of studies focusing on retinoblastoma protein's role in apoptosis

Bacterial ‘fight club’ approach effective for finding new drugs from natural sources

Discovery sheds light on how the Hippo pathway maintains cellular balance

Small intestine causes chronic inflammation in obese patients

Drug discovery experts receive £3m to find new treatments for Alzheimer's disease

Researchers find easy way to produce carbon nanoparticles that can carry drugs to targeted tissues

Researchers explore the science of exosomes in heart repair

MGH researchers develop new approach to skin rejuvenation

RPCI receives NCI grant to continue research program on photodynamic therapy for head and neck cancers

Fruit flies helping FAU researchers to discover novel genes responsible for neuroprotection

DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

α-synuclein conformation may underlie neurodegenerative variability

Daily dose of aspirin effective at blocking breast tumor growth

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