Clinical Trial News and Research

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Half-dose COVID-19 booster elicits similar immune response with fewer side effects

Reducing the dose of a widely used COVID-19 booster vaccine produces a similar immune response in adults to a full-dose with fewer side effects, according to a new study.

23 Nov 2023

Numbing agent lidocaine may have cancer-fighting properties

Lidocaine - often used as numbing agent for outpatient medical procedures - activates certain bitter taste receptors through two unique mechanisms that result in cancer cell death, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

22 Nov 2023

Acoustic stimulation of the brain may ease persistent symptoms after mild traumatic brain injury

New research indicates that acoustic stimulation of the brain may ease persistent symptoms in individuals who experienced mild traumatic brain injury in the past.

22 Nov 2023

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Researchers investigate the effects of high-dose fluvoxamine among patients with mild-to-moderate COVID-19.

22 Nov 2023

Study shows how probiotic Bifidobacteria longum can help relieve constipation

Scientists have identified the genes in the probiotic Bifidobacteria longum responsible for improving gut motility.

21 Nov 2023

Drug for children with achondroplasia may help reduce chances of SIDS

A drug that boosts bone growth in children with the most common form of dwarfism, may also reduce their chances of sudden infant death syndrome, sleep apnea and needing surgery, according to a new study.

21 Nov 2023

Immunotherapy drug is safe and may benefit overall survival for patients with advanced NSCLC

For patients with advanced or metastatic non-small cell lung cancer (NSCLC) and limited performance status, an immune checkpoint inhibitor drug called durvalumab is safe and may benefit overall survival, according to a new eClinicalMedicine study by UPMC Hillman Cancer Center researchers.

21 Nov 2023

PROFID EHRA trial aims to personalize the prevention of sudden cardiac death after myocardial infarction

The first clinical trial to challenge the routine implantation of a defibrillator in myocardial infarction survivors with heart failure has enrolled its first patient.

21 Nov 2023

Call for improved data sharing practices in the pharmaceutical industry

Development of potential or improved anti-cancer treatments are being blocked or slowed down by lack of transparency in data sharing between pharmaceutical companies and research groups, according to cancer clinicians, researchers and consumers.

21 Nov 2023

Nut consumption linked to improved male fertility, systematic review reveals

A systematic review finds that consuming at least 60 grams of nuts daily significantly enhances male fertility by improving sperm vitality, motility, and morphology, while evidence for nut consumption's impact on female fertility remains limited.

20 Nov 2023

Young people may be more susceptible to the effects of elevated blood cholesterol and hypertension

Young people may be more susceptible to the effects of the risk factors for developing atherosclerosis. According to a study carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), younger people are especially vulnerable to the damaging effects of elevated blood cholesterol and hypertension, two of the major modifiable cardiovascular risk factors.

20 Nov 2023

New study unravels the mystery of red wine headaches

A red wine may pair nicely with the upcoming Thanksgiving meal. But for some people, drinking red wine even in small amounts causes a headache.

20 Nov 2023

Breakthroughs in TB prevention offer hope for children

Taking a common antibiotic could more than half the risk of children becoming sick with multidrug resistant tuberculosis (MDR-TB), according to findings presented this week at a conference on lung health.

20 Nov 2023

Academic medical centers may help mitigate structural racism in cardiovascular care for Black women

Investigators from the Barbra Streisand Women’s Heart Center in the Smidt Heart Institute at Cedars-Sinai have found that among a cohort of women with obstructive coronary artery disease treated at academic medical centers, racial and ethnic disparities did not impact their long-term outcomes.

20 Nov 2023

What are the minimal clinically important differences in the Diabetes Distress Scale–17 and its four subscales?

Adistribution-based minimal clinically important difference (MCID) for the Diabetes Distress Scale–17 (DDS-17) and its four subscales.

20 Nov 2023

Breakthrough in tuberculosis treatment: TB-PRACTECAL trial reveals efficacy of new oral regimen

The TB-PRACTECAL clinical trial outcomes, which evaluated the efficacy and safety of oral bedaquiline.

20 Nov 2023

Ingestible capsule can monitor vital signs from within the patient's GI tract

Diagnosing sleep disorders such as sleep apnea usually requires a patient to spend the night in a sleep lab, hooked up to a variety of sensors and monitors.

17 Nov 2023

Long-term monitoring of gene therapy patients crucial for safety, study says

Medical research has shown promising results regarding the potential of gene therapy to cure genetic conditions such as sickle cell disease and the findings of this study, published in Nature Medicine, offer important new insights into processes happening in the body after treatment.

16 Nov 2023

Landmark studies present new era for bladder cancer treatment

After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations.

16 Nov 2023

Study reveals acupuncture and massage as effective pain management in advanced cancer

In a clinical trial, acupuncture and massage therapy significantly reduced pain, fatigue, and insomnia, enhancing quality of life in advanced cancer patients over 26 weeks.

16 Nov 2023

Clinical Trial News and Research

Half-dose COVID-19 booster elicits similar immune response with fewer side effects

Numbing agent lidocaine may have cancer-fighting properties

Acoustic stimulation of the brain may ease persistent symptoms after mild traumatic brain injury

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Study shows how probiotic Bifidobacteria longum can help relieve constipation

Drug for children with achondroplasia may help reduce chances of SIDS

Immunotherapy drug is safe and may benefit overall survival for patients with advanced NSCLC

PROFID EHRA trial aims to personalize the prevention of sudden cardiac death after myocardial infarction

Call for improved data sharing practices in the pharmaceutical industry

Nut consumption linked to improved male fertility, systematic review reveals

Young people may be more susceptible to the effects of elevated blood cholesterol and hypertension

New study unravels the mystery of red wine headaches

Breakthroughs in TB prevention offer hope for children

Academic medical centers may help mitigate structural racism in cardiovascular care for Black women

What are the minimal clinically important differences in the Diabetes Distress Scale–17 and its four subscales?

Breakthrough in tuberculosis treatment: TB-PRACTECAL trial reveals efficacy of new oral regimen

Ingestible capsule can monitor vital signs from within the patient's GI tract

Long-term monitoring of gene therapy patients crucial for safety, study says

Landmark studies present new era for bladder cancer treatment

Study reveals acupuncture and massage as effective pain management in advanced cancer

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