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Novel tool uses AI to predict the efficacy of genome-editing repair options

Researchers at the University of Zurich have developed a new tool that uses artificial intelligence to predict the efficacy of various genome-editing repair options.

2 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

Deep-learning based filter removes false positives, improves the accuracy of cancer diagnosis

Next-generation cancer strategies rely on next-generation gene sequencing (NGS), which paves the way for new techniques and tools to detect mutations and determine patient therapy.

1 Feb 2023

Risk factors for Omicron reinfections among previously infected frontline workers in the United States

Researchers examined a prospective cohort of frontline workers in the United States (US) previously infected with SARS-CoV-2. They attempted to identify risk factors that made this highly vulnerable population prone to reinfection by SARS-CoV-2 new variant of concern (VOC), Omicron, known for its high immune evading potential.

1 Feb 2023

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Scientists review existing literature to evaluate the advancements in genomic and exome sequencing for the accurate detection of undiagnosed syndromes.

1 Feb 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

The present study provided strong evidence that supported the hypothesis that hyperinsulinemia and glucose intolerance cause infertility in women.

31 Jan 2023

Study finds link between tumor microbiome and immune system in sarcoma patients

In a significant new study, UC Davis Comprehensive Cancer Center researchers have uncovered a link between a patient's microbiome and their immune system that can potentially be used to improve the treatment of soft tissue sarcoma.

30 Jan 2023

Human immunodeficiency virus and hepatitis C virus detection using ribonucleic acid sequencing among smokers

Researchers identified serological Hepatitis C virus (HCV) signatures and human immunodeficiency virus (HIV) signatures through the secondary utilization of ribonucleic acid sequencing (RNA-seq) analysis data among previous and existing smokers with or without COPD (chronic obstructive pulmonary disease).

30 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

A recent study evaluates the presence of SARS-CoV-2 in children’s tonsils during the COVID-19 pandemic.

29 Jan 2023

Researchers discover how measles virus can cause a rare but fatal neurological disorder

Researchers in Japan have uncovered the mechanism for how the measles virus can cause subacute sclerosing panencephalitis, or SSPE, a rare but fatal neurological disorder that can occur several years after a measles infection.

27 Jan 2023

DePaul and Rosalind Franklin fund research projects that bring together AI, biomedical discovery and health care

DePaul University and Rosalind Franklin University of Science and Medicine are funding three faculty research projects that bring together artificial intelligence, biomedical discovery and health care.

27 Jan 2023

Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

27 Jan 2023

Research offers hope for patients affected by rare, hereditary metabolic disease

Methylmalonic aciduria (MMA) is a metabolic disorder that affects approximately one in 90,000 newborns; both parents must carry a genetic predisposition to the disease.

26 Jan 2023

Novel papillomaviruses identified in Malayan and Chinese pangolins

Researchers identify two novel lineages of papillomaviruses by mining the genome data of Chinese and Malayan pangolins.

26 Jan 2023

Scientists receive $2.9 million NIH grant to better understand the genetics of IBD in Hispanics

After studying the genetic sequences of more than 100,000 people, researchers around the country have started to uncover the root causes of inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis.

26 Jan 2023

Study identifies the DNA roots of resistance to targeted cancer therapy

A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics.

26 Jan 2023

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

26 Jan 2023

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

In a recent study posted to the bioRxiv* preprint server, researchers designed two dumbbell-1 (DB-1) mutant Zika virus (ZIKV) infectious clones termed ZIKV-TL.PK and ZIKV-p.2.5’.

26 Jan 2023

Genome News and Research

Novel tool uses AI to predict the efficacy of genome-editing repair options

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Deep-learning based filter removes false positives, improves the accuracy of cancer diagnosis

Risk factors for Omicron reinfections among previously infected frontline workers in the United States

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Study demonstrates intrahost MPXV variation within a single lesion

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

Study finds link between tumor microbiome and immune system in sarcoma patients

Human immunodeficiency virus and hepatitis C virus detection using ribonucleic acid sequencing among smokers

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

Researchers discover how measles virus can cause a rare but fatal neurological disorder

DePaul and Rosalind Franklin fund research projects that bring together AI, biomedical discovery and health care

Researchers identify an unexpected driver of cancer immunotherapy resistance

Research offers hope for patients affected by rare, hereditary metabolic disease

Novel papillomaviruses identified in Malayan and Chinese pangolins

Scientists receive $2.9 million NIH grant to better understand the genetics of IBD in Hispanics

Study identifies the DNA roots of resistance to targeted cancer therapy

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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