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Liver disease in children with Alagille Syndrome caused by malformations of bile ducts

Serious liver and heart problems can affect children with Alagille Syndrome early in life. While there is as yet no cure, researchers at Karolinska Institutet in Sweden have discovered that the liver disease part of the syndrome is caused by specific malformations of the bile ducts.

21 Nov 2017

Research paves way for development of vaccines against mycoplasma bacteria

Mycoplasma bacteria are one of the most common causes of bacterial pneumonia in children. It is still unclear how the disease develops.

21 Nov 2017

Preclinical study shows clear path toward effective treatment for rare bone disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE).

20 Nov 2017

Enterovirus vaccine protects against virus-induced diabetes in mouse model

Scientists at the University of Tampere and the Karolinska Institutet have demonstrated that an enterovirus vaccine can protect against virus-induced diabetes in a mouse model for Type 1 diabetes.

20 Nov 2017

Cancer drugs may offer new way to control high blood pressure

Drugs designed to halt cancer growth may offer a new way to control high blood pressure (hypertension), say Georgetown University Medical Center investigators.

20 Nov 2017

Drug used to prevent and treat malaria may also be effective for Zika virus

A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika virus.

17 Nov 2017

Scientists unveil pathology underlying optic nerve hypoplasia in children

Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have revealed the pathology of cells and structures stricken by optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.

16 Nov 2017

Heart injury triggers irreversible dysregulation that alters cardiosplenic and cardiorenal networks

Heart failure after a heart attack is a global epidemic leading to chronic heart failure pathology. About 6 million people in the United States and 23 million worldwide suffer from this end-stage disease.

15 Nov 2017

Study identifies molecular pathway critical to development of fibrosis

A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis - scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs.

15 Nov 2017

UCR-led research discovers that human protein could be used to treat sepsis

A research team led by a biomedical scientist at the University of California, Riverside has discovered that the human protein resistin could be used to treat sepsis, the body's extreme and uncontrolled immune response to an infection.

14 Nov 2017

Tulane professor wins Department of Defense grant for research into arteriovenous malformations

Tulane University's Stryder Meadows, a cell and molecular biology professor, received a $1.7 million grant from the Department of Defense to study how arteriovenous malformations (AVM), which are defects in arteries, veins and capillaries, form Hereditary Hemorrhagic Telangiectasia (HHT), a genetic disorder that affects about 1 in 5,000 people.

14 Nov 2017

Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy

Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?

14 Nov 2017

New drug shows promise in mouse model of autism disorder

Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the mice.

14 Nov 2017

Scientists identify critical player in Alzheimer's disease pathogenesis

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check.

14 Nov 2017

Dengue immunity can provide protection from subsequent Zika infection

Manifestations of Zika virus (ZIKV) infection differ drastically. Sometimes they are catastrophic, most notably when they cause microcephaly in some babies born to infected mothers.

13 Nov 2017

Scientists develop novel mouse model to capture pathology of sporadic ALS and FTD

Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and death of nerve cells, which leads to problems with movement or mental functioning. Examples include Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

13 Nov 2017

New biomarker could lead to early detection of Alzheimer's disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that could lead to the early detection of Alzheimer's disease (AD).

10 Nov 2017

Malaria parasites’ decision making influenced by fatty molecule in human blood

Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.

9 Nov 2017

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

By connecting highly effective cancer immunotherapy drugs such as anti-CTLA4 (ipilimumab) and anti-PD-L1 (atezolizumab) to peptides that bind to tissues in and around tumors, a research team based at the University of Chicago found a way to improve the drugs' impact while limiting treatment-related side effects.

9 Nov 2017

Researchers use gold nanoshells to effectively release cancer drugs inside tumors

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside cancer cells in laboratory cultures.

8 Nov 2017

Mouse Model News and Research

Liver disease in children with Alagille Syndrome caused by malformations of bile ducts

Research paves way for development of vaccines against mycoplasma bacteria

Preclinical study shows clear path toward effective treatment for rare bone disease

Enterovirus vaccine protects against virus-induced diabetes in mouse model

Cancer drugs may offer new way to control high blood pressure

Drug used to prevent and treat malaria may also be effective for Zika virus

Scientists unveil pathology underlying optic nerve hypoplasia in children

Heart injury triggers irreversible dysregulation that alters cardiosplenic and cardiorenal networks

Study identifies molecular pathway critical to development of fibrosis

UCR-led research discovers that human protein could be used to treat sepsis

Tulane professor wins Department of Defense grant for research into arteriovenous malformations

Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy

New drug shows promise in mouse model of autism disorder

Scientists identify critical player in Alzheimer's disease pathogenesis

Dengue immunity can provide protection from subsequent Zika infection

Scientists develop novel mouse model to capture pathology of sporadic ALS and FTD

New biomarker could lead to early detection of Alzheimer's disease

Malaria parasites’ decision making influenced by fatty molecule in human blood

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

Researchers use gold nanoshells to effectively release cancer drugs inside tumors

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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