Proliferation News and Research

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Position paper shows evidence-based analysis of nutritional factors that influence athletic performance

An assistant professor in the UK College of Health Sciences is the lead author on a paper that is being hailed as the most important single source of information in the field of sports nutrition to date.

27 Feb 2016

New infection-fighting bandages for serious burn victims

Serious burn victims are immunocompromised and may be missing skin on parts of their body, and this makes them highly vulnerable to bacteria. Thanks to progress in intensive care, they are decreasingly likely to die from burn trauma. Death is more commonly the result of infections that can occur several months after being hospitalized. The bandages used to treat burns actually represent a real breeding ground for microbes.

26 Feb 2016

Aggregated forms of transthyretin can trigger JIA development

Juvenile idiopathic arthritis (JIA) is a the most common form of arthritis in children and affects approximately 50,000 individuals in the United States alone. Previous research suggested that autoimmune responses cause JIA, but the specific antigens that are responsible for driving autoimmunity have not been identified.

26 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

High-salt diet may contribute to liver damage

A sprinkle of salt can bring out the flavor of just about any dish. However, it's well known that too much can lead to high blood pressure, a potentially dangerous condition if left untreated.

24 Feb 2016

Researchers make some progress in determining causes for glioblastoma multiforme

A research team, with the participation of the University of Granada (UGR), has made some progress in determining the causes for glioblastoma multiforme (GBM), one of the most aggressive brain tumors known, to be resistant to the drugs currently used, which is one of the main limitations of its treatment.

18 Feb 2016

Amgen announces availability of Kyprolis (carfilzomib) in the UK for treatment of relapsed multiple myeloma

Amgen today announced that Kyprolis in combination with lenalidomide and dexamethasone is now available in the UK for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

16 Feb 2016

Anti-cancer drug delays onset of Alzheimer's disease

Researchers have identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer's disease, in a similar way to how statins are able to reduce the risk of developing heart disease.

15 Feb 2016

Humans can tolerate parasites responsible for sleeping sickness, Chagas disease, leishmaniasis

Humans can tolerate the parasites responsible for the sleeping sickness, Chagas disease and leishmaniasis for many years.

12 Feb 2016

Study holds promise for new alternatives to treat leukemia

Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.

11 Feb 2016

Study reveals link between genomic instability, aneuploidy and cancer

A recent analysis of 43,205 human tumours unveiled that 68% of solid tumours are aneuploid, that is to say, they have an altered number of chromosomes. In recent years, scientists have attempted to clarify whether this aneuploidy contributes to tumour development or whether it is a co-lateral effect of the genomic instability of cancer cells, which increase the rate of mutations and the likelihood of cancer.

9 Feb 2016

Duchenne muscular dystrophy: direct effect on muscle stem cells? An interview with Dr Rudnicki

For twenty years, it has been understood that dystrophin is expressed in differentiated muscle fibers where it is part of a protein complex that crosses the membrane and connects the extracellular matrix to the actin network inside the cell to provide structural integrity.

5 Feb 2016

New research identifies key enzyme linked to age-related increases in cancer and inflammation

For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

4 Feb 2016

Research: Adenosine deaminase may help activate immune system against HIV

New research findings published in the February 2016 issue of the Journal of Leukocyte Biology, suggest that a new therapeutic strategy for HIV may already be available by repurposing an existing prescription drug.

3 Feb 2016

Discovery could lead to new leukaemia therapies

Human blood cells have olfactory receptors that respond to Sandalore. This could provide a starting point for new leukaemia therapies, as researchers from Bochum report in in the journal "Cell Death Discovery".

3 Feb 2016

MYB-QKI fusion gene that drives pediatric low-grade gliomas poses a triple threat

Oncology researchers have discovered that an abnormal fused gene that drives pediatric brain tumors poses a triple threat, operating simultaneously through three distinct biological mechanisms—the first such example in cancer biology.

2 Feb 2016

Biochemical compound demonstrates increasing potential for use in cancer imaging

In the paper, an international team reviewed studies conducted over the past 30 years on a particular tracer, called “18F-FLT,” and found that it has the potential to improve diagnostic imaging, and thus treatment, of some cancers.

2 Feb 2016

Study provides vital information about mechanisms governing DNA repair

DNA damage can lead to gene inactivation or deregulation and cause various diseases such as cancer; however, many DNA repair mechanisms allow cells to survive against such damage. A study lead by Antoine Simoneau of the laboratory of Dr. Hugo Wurtele, a researcher in immunology-oncology at the Maisonneuve-Rosemont Hospital (CIUSS de l'Est-de-l'Île-de-Montréal) and professor at the Faculty of Medicine, University of Montreal, and recently published in the prestigious journal Nucleic Acids Research, provides valuable information about certain mechanisms governing DNA repair.

31 Jan 2016

Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

A first-in-class sphingosine kinase 2 inhibitor slowed the growth of castration-resistant prostate cancer cells, in part by inhibiting the enzyme dihydroceramide desaturase (DEGS), but did not kill them, according to the results of preclinical in vitro and in vivo studies published in the December 2015 issue of Molecular Cancer Therapeutics by researchers at the Medical University of South Carolina and others.

30 Jan 2016

Using acidity to detect cancer

Normally, tissues demonstrate a slightly acidic intracellular pH (pHi) and slightly alkaline extracellular pH (pHe). However, proliferating tissues demonstrate transient pH Gradient Reversal i.e. alkalinization of pHi and acidification of pHe.

26 Jan 2016