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Drug Discovery 2023: A Conversation with Professor Janet Hemingway

We spoke to Professor Janet Hemingway, founding Director of iiCON and Professor of Tropical Medicine at Liverpool School of Tropical Medicine.

From ELRIG (UK) Ltd. 9 Oct 2023

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Using antigenic cartography, researchers analyzed cross-reactivity patterns of SARS-CoV-2 variants and the effect of spike-protein changes on post-infection and vaccination immune responses. The study illuminated unique neutralization profiles and underscored the evolving defense mechanisms with repeated immunizations.

8 Oct 2023

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

The NVX-CoV2373 COVID-19 vaccine offers significant protection against symptomatic infections, but its effectiveness against SARS-CoV-2 declines within four months, according to a study in JAMA Network Open using Italian data. However, its protection against symptomatic COVID-19 seems to remain stable during this period.

8 Oct 2023

Researchers develop innovative treatment option for therapy-resistant epilepsy

Neuroscientist Professor Sonja Bröer from Freie Universität Berlin is involved in the development of an innovative treatment option for therapy-resistant epilepsy.

6 Oct 2023

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Inhaled nitric oxide gas widens blood vessels in the lungs and is used to treat severe cardio-pulmonary conditions in newborns and adults.

6 Oct 2023

Study: Integrated health care for chronic conditions feasible and cost-effective in sub-Saharan Africa

Integrated health care for chronic high-burden conditions in sub-Saharan Africa is feasible and health services could deliver high-quality services for less cost than with the current approach of separate vertical care for each condition, a new study led by UCL researchers shows.

6 Oct 2023

Relationship intervention programs can help couples feel more appreciated

When we're married or in a long-term romantic relationship, we may eventually come to take each other for granted and forget to show appreciation.

6 Oct 2023

Grape consumption improves key markers of eye health in older adults

In a recent randomized, controlled human study, consuming grapes for 16 weeks improved key markers of eye health in older adults.

6 Oct 2023

A telehealth model to support remote diabetes self-care

Researchers develop and test the effectiveness of a Virtual Diabetes Specialty Clinic (VDiSC), a virtual model facilitating comprehensive diabetes care remotely.

6 Oct 2023

Breakthrough study shows immunotherapy can help prevent bladder cancer recurrence

The Alliance for Clinical Trials in Oncology today announced that the Alliance Data and Safety Monitoring Board (DSMB) determined that the phase III AMBASSADOR (A031501) trial met one of its dual primary endpoints of disease-free survival (DFS) for the adjuvant treatment of patients with localized muscle-invasive urothelial carcinoma (MIUC) and locally advanced urothelial carcinoma.

5 Oct 2023

Remote ischemic conditioning for acute stroke

The effect of remote ischemic conditioning (RIC) on functional outcomes in patients with acute stroke.

5 Oct 2023

Esketamine outperforms one of the standard drugs for treatment-resistant major depression

A major clinical trial shows that the drug, esketamine, one of the two main forms of ketamine, outperforms one of the standard treatments for treatment-resistant major depression.

4 Oct 2023

New nasal vaccine shows promise in preventing deadly Strep A infections

As Streptococcus A cases continue to be prevalent in Queensland and internationally, a new nasal vaccine could provide long-term protection from the deadly bacteria.

4 Oct 2023

Newly identified protein markers could signal early development of metastatic lung cancer

Researchers at Mays Cancer Center at The University of Texas Health Science at San Antonio (UT Health San Antonio) have identified protein markers that could signal for early development of metastatic lung cancer, providing possibilities for new treatment.

4 Oct 2023

How vitamin D and genetics shape early brain development

The study examined how vitamin D levels and vitamin D binding protein genotypes in both pregnant mothers and their children aged 3-5, impact early childhood neurodevelopment. Findings suggest that higher vitamin D concentrations in children were associated with better neurodevelopmental scores, with additional influences from sociodemographic factors and certain genetic variations.

4 Oct 2023

Early metformin therapy falls short in curbing gestational diabetes woes

In a significant randomized clinical trial, early metformin therapy was tested for its potential to lessen insulin dependence and enhance glycemic control in gestational diabetes-afflicted pregnant women; however, it yielded no improvements in diabetes symptoms. While metformin reduced maternal weight gain, its effects on primary diabetes symptoms and other secondary outcomes like infant weight gain were mixed, indicating a need for further focused research to unravel these associations.

4 Oct 2023

New meningitis vaccine safe and effective for infants in Africa

University of Maryland School of Medicine (UMSOM) researchers, as part of the Infectious Diseases Clinical Research Consortium (IDCRC), provided an interim analysis showing that the pentavalent (NmCV-5) meningitis vaccine is safe for use in 9-month-old infants in the meningitis belt of sub-Saharan Africa.

3 Oct 2023

Clinical Trial News and Research

Drug Discovery 2023: A Conversation with Professor Janet Hemingway

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

Researchers develop innovative treatment option for therapy-resistant epilepsy

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Study: Integrated health care for chronic conditions feasible and cost-effective in sub-Saharan Africa

Relationship intervention programs can help couples feel more appreciated

Grape consumption improves key markers of eye health in older adults

A telehealth model to support remote diabetes self-care

Breakthrough study shows immunotherapy can help prevent bladder cancer recurrence

Remote ischemic conditioning for acute stroke

Esketamine outperforms one of the standard drugs for treatment-resistant major depression

New nasal vaccine shows promise in preventing deadly Strep A infections

Newly identified protein markers could signal early development of metastatic lung cancer

How vitamin D and genetics shape early brain development

Early metformin therapy falls short in curbing gestational diabetes woes

New meningitis vaccine safe and effective for infants in Africa

Stereotactic radiation therapy offers new hope for older adults with inoperable kidney cancer

Breaking the cycle of chronic back pain: new study reveals the power of shifting pain beliefs

Novel deep learning model to assess Alzheimer's disease progression risk

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