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Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore (NUS) have discovered a biomarker, called adenosine deaminase acting on RNA-1 (ADAR1), which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

New approach aims to prevent brain cancer recurrence by attacking tumors at the source

Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery identified immune system targets on cancer stem cells - cells from which malignant brain tumors are believed to originate and regenerate - and created an experimental vaccine to attack them.

6 Jan 2014

Clinical features not sufficiently pathognomonic in pneumonia

Clinical signs and symptoms are not sufficiently reliable to distinguish the different etiologies of pneumonia, Dutch researchers report.

6 Jan 2014

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

Esophageal Squamous Cell Carcinoma, the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore have discovered a biomarker, called adenosine deaminase acting on RNA-1, which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

TauRx Therapeutics adds new research centers across U.S. for Alzheimer’s clinical trials

TauRx Therapeutics Ltd, a clinical-stage biopharmaceutical company developing a novel treatment for Alzheimer's disease, has expanded its international clinical trials by adding new research centers across the U.S.

6 Jan 2014

New study highlights the importance of beta3-integrin protein in cancer research

A protein that has been at the centre of cancer drug design for the last 20 years should not be given up on according to new research from the University of East Anglia (UEA).

6 Jan 2014

Plant-based milk for people with lactose or gluten intolerance

Researchers at the Universitat Politècnica de València have obtained new products fermented with probiotic bacteria from grains and nuts - what is known as plant-based or vegetable "milks" - which are an alternative to conventional yogurts.

6 Jan 2014

Researchers explore treatment targets for hypobaric hypoxia brain injury

Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction, and is involved in hypoxic brain injury. Dr. Jianyu Li and colleagues from Logistics College of Chinese People's Armed Police Forces evaluated the degree of brain damage with different exposure times to hypoxia and further investigate the differential expression of cerebral mitochondrial proteins by comparative proteomic analysis, in a broader attempt to search for treatment targets of hypobaric hypoxia brain injury.

6 Jan 2014

Researcher reveals how temperature impacts development of embryos

In nature, animals face a broad range of temperatures, and at times the heat can become taxing. When it becomes too hot to survive, some animals can simply migrate to more favorable climates, but what if you are a mere embryo confined within an egg and cannot escape the heat?

6 Jan 2014

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease.

6 Jan 2014

Hopkins scientists design new mouse that mimics common form of leukemia

Johns Hopkins Kimmel Cancer Center investigators have genetically engineered a new mouse that mimics a common form of leukemia in humans. Studying the model could lead to new understanding of the disease, they say.

6 Jan 2014

Increased activities of ClC-3 chloride channel may be involved in hippocampal neuronal apoptosis

Over-production of nitric oxide and ion disturbance are involved in neuronal apoptosis around the ischemic area following ischemic brain injury. Prof. Quanzhong Chang and team from Zhuhai Campus of Zunyi Medical College in China established a rat model of hippocampal neuronal apoptosis by using 3-morpholinosyndnomine (SIN-1), a nitric oxide donor.

6 Jan 2014

Study shows endoplasmic reticulum stress plays important role in diabetic retinopathy

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels.

5 Jan 2014

Discovery opens new pathways for treatment of toxoplasmosis and malaria

A newly identified protein and other proteins it interacts with could become effective targets for new drugs to control the parasite that cause toxoplasmosis, researchers led by investigators at Indiana University School of Medicine have reported.

3 Jan 2014

Study indicates that smoking disrupts circadian clock function in both lungs and brain

As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal suggests that smoking disrupts the circadian clock function in both the lungs and the brain.

3 Jan 2014

Biologists discover effective strategy that could prevent immune system from rejecting grafts

Biologists at UC San Diego have discovered an effective strategy that could prevent the human immune system from rejecting the grafts derived from human embryonic stem cells, a major problem now limiting the development of human stem cell therapies.

3 Jan 2014

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive mechanisms are not well understood.

3 Jan 2014

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Researchers from Huntsman Cancer Institute (HCI) at the University of Utah discovered a cellular mechanism that drives the spread of breast cancer to other parts of the body (metastasis), as well as a therapy which blocks that mechanism. The research results were published online in the journal Cell Reports on January 2.

3 Jan 2014

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation.

2 Jan 2014

Study reveals potential links to the underlying causes of cancers

New research by scientists at the University of Exeter has shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide - a finding with potential links to the underlying causes of many cancers.

2 Jan 2014

Protein C News and Research

Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

New approach aims to prevent brain cancer recurrence by attacking tumors at the source

Clinical features not sufficiently pathognomonic in pneumonia

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

TauRx Therapeutics adds new research centers across U.S. for Alzheimer’s clinical trials

New study highlights the importance of beta3-integrin protein in cancer research

Plant-based milk for people with lactose or gluten intolerance

Researchers explore treatment targets for hypobaric hypoxia brain injury

Researcher reveals how temperature impacts development of embryos

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Hopkins scientists design new mouse that mimics common form of leukemia

Increased activities of ClC-3 chloride channel may be involved in hippocampal neuronal apoptosis

Study shows endoplasmic reticulum stress plays important role in diabetic retinopathy

Discovery opens new pathways for treatment of toxoplasmosis and malaria

Study indicates that smoking disrupts circadian clock function in both lungs and brain

Biologists discover effective strategy that could prevent immune system from rejecting grafts

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Study reveals potential links to the underlying causes of cancers

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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