B Cell News and Research

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Novel method can edit genes with substantially fewer errors

Gene therapy is an emerging strategy to treat diseases caused by genetic abnormalities. One form of gene therapy involves the direct repair of a defective gene, using genome-editing technology such as CRISPR-Cas9. Despite its therapeutic potential, genome editing can also introduce unwanted and potentially harmful genetic errors that limit its clinical feasibility.

5 Feb 2018

Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

Researchers shine light on ‘molecular butcher’ using neutron beams

Tucked away inside cell membranes, a molecular butcher does the bidding of healthy cells but also of disease agents. It has been operating out of clear view, but researchers just shined a mighty spotlight on it.

2 Feb 2018

Tumor activity found in male rats exposed to radiofrequency radiation

High exposure to radiofrequency radiation in rodents resulted in tumors in tissues surrounding nerves in the hearts of male rats, but not female rats or any mice, according to draft studies from the National Toxicology Program.

2 Feb 2018

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

As part of a breast-cancer diagnosis, doctors analyze the tumor to determine which therapies might best attack the malignancy.

2 Feb 2018

Specialized cellular structures may hold clues to health effects of psychological stress

How does psychological stress translate into physical health effects? A key piece of the puzzle may be found in specialized cellular structures known as mitochondria, according to a pair of articles in the January issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society.

2 Feb 2018

Scientists synthesize new multifunctional compound that has anti-tumor properties

A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects.

2 Feb 2018

Researchers discover gene network that regulates the motor neuron development in growing embryo

UCLA researchers have discovered the inner workings of a gene network that regulates the development of spinal motor neurons in the growing chicken and mouse embryo.

2 Feb 2018

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Microcephaly, brain calcification, skeletal alterations, auditory and visual deficits - these are examples of the damage that can be caused by Zika virus in babies born to mothers infected during pregnancy.

2 Feb 2018

Researchers identify cause of severe genetic disease

Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes.

2 Feb 2018

Scientists develop immune-stimulating injections against cancer

A team of researchers have developed two immune-stimulating injections, that removed all traces of cancer when injected directly into solid mouse tumors.

2 Feb 2018

Geneva researchers highlight new way to control tumor progression

For a tumor to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumor vascularization is therefore an interesting anti-tumor therapy that has been explored over the last ten years.

2 Feb 2018

New ChIPseq kit is optimized for fresh and frozen tissue samples

The new, high-performance Chromatrap ChIP-Seq kit (v.1.5) is optimized to work from fresh and frozen extracted tissue, as well as cell lines.

From Chromatrap® - Porvair Sciences Ltd 2 Feb 2018

New modular platform offers robust biological approach that targets endless number of diseases

The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies than currently available. Most therapeutic approaches ignore the dynamic molecular network of genes, targeting instead only very few selected disease-related genes.

1 Feb 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

Findings provide better understanding of cell membrane components

Research conducted by Toyohashi University of Technology in collaboration with Tohoku University elucidated the fusion process of proteoliposomes with an artificial lipid bilayer and the mechanism behind this process.

1 Feb 2018

Two bacterial species collaborate to drive development of colon cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

1 Feb 2018

Historic study involving Simmons Cancer Center shows effectiveness of CAR-T therapy

A historic study involving researchers from UT Southwestern's Harold C. Simmons Comprehensive Cancer Center demonstrates the effectiveness of CAR-T therapy, which uses genetically modified immune cells to treat acute lymphoblastic leukemia (ALL) in children and young adults. The research appears in the New England Journal of Medicine.

1 Feb 2018

Neurons get stretches of orderly drumroll-like rumblings speckled with strong impulses

A neuron firing deep in the brain might sound a little like: Drumroll...cymbal crash! Drumroll...cymbal crash! Repeat. With emphasis on "repeat," according to a new study.

1 Feb 2018

Harvard scientists identify molecular machinery responsible for dopamine release in the brain

Studied for decades for its critical role in movement control and reward-seeking behaviors, the neurotransmitter dopamine has been the focus of numerous efforts to understand its activity, particularly when it goes awry in disorders such as Parkinson's and addiction.

1 Feb 2018

B Cell News and Research

Novel method can edit genes with substantially fewer errors

Researchers use innovative method to screen kinases for cancer drug's effectiveness

Researchers shine light on ‘molecular butcher’ using neutron beams

Tumor activity found in male rats exposed to radiofrequency radiation

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

Specialized cellular structures may hold clues to health effects of psychological stress

Scientists synthesize new multifunctional compound that has anti-tumor properties

Researchers discover gene network that regulates the motor neuron development in growing embryo

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Researchers identify cause of severe genetic disease

Scientists develop immune-stimulating injections against cancer

Geneva researchers highlight new way to control tumor progression

New ChIPseq kit is optimized for fresh and frozen tissue samples

New modular platform offers robust biological approach that targets endless number of diseases

Study unravels developmental splicing program that promotes neuronal maturation

Findings provide better understanding of cell membrane components

Two bacterial species collaborate to drive development of colon cancers

Historic study involving Simmons Cancer Center shows effectiveness of CAR-T therapy

Neurons get stretches of orderly drumroll-like rumblings speckled with strong impulses

Harvard scientists identify molecular machinery responsible for dopamine release in the brain

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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