Protein C News and Research

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Study could lead towards a personalised medicine for chemoresistant lymphomata

To date, tests have only been carried out on cells, but a piece of research conducted by the Department of Genetics at the UPV/EHU's Faculty of Medicine in collaboration with MD Anderson and the CNIO is opening up the door for the treatment of lymphoma types that have a lower survival rate. The study of the molecular characteristics of the tumours would enable molecules that are altered in a specific way to be identified and turned into new therapeutic targets that would improve the prognosis of patients with chemoresistant lymphomata.

16 Dec 2013

Four U.S. researchers to receive grants to improve cognition in individuals living with Down syndrome

The Scientific Advisory Board of the Jerome Lejeune Foundation USA has recommended 4 U.S. researchers to receive grants from the Foundation for its second funding cycle of 2013.

15 Dec 2013

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

The Genetics Society of America (GSA) is pleased to announce the selection of eleven early career researchers - five graduate students and six postdoctoral researchers - as recipients of a spring 2014 DeLill Nasser Award for Professional Development in Genetics.

15 Dec 2013

Research reveals that deletion of Epac1 gene protects from fatal rickettsiosis

Researchers at the University of Texas Medical Branch at Galveston have discovered a way to block a disease pathway that could be a breakthrough in defeating some of the world's most devastating human infections.

14 Dec 2013

Scientists reveal how two genes interact to kill broad range of cancer cells

Scientists from Virginia Commonwealth University Massey Cancer Center have revealed how two genes interact to kill a wide range of cancer cells. Originally discovered by the study's lead investigator Paul B. Fisher, M.Ph., Ph.D., the genes known as mda-7/IL-24 and SARI could potentially be harnessed to treat both primary and metastatic forms of brain, breast, colon, lung, ovary, prostate, skin and other cancers.

14 Dec 2013

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses.

14 Dec 2013

Researchers study zebrafish embryo skin to find link between low calcium and colon cancer

A tiny, transparent fish embryo and a string of surprises led scientists to a deeper understanding of the perplexing link between low calcium and colon cancer.

14 Dec 2013

Researchers test promising new breast cancer drugs

The first investigator results from an unprecedented nationwide effort to test promising new breast cancer drugs before the tumor is removed were presented during the 2013 San Antonio Breast Cancer Symposium.

14 Dec 2013

New UCSF-led study links obesity to development of chronic kidney disease

A new UCSF-led study of nearly 3,000 individuals links obesity to the development of kidney disease. The work also shows that, when properly measured, declines in kidney function are detectable long before the emergence of other obesity-related diseases such as diabetes and high blood pressure.

14 Dec 2013

Skin cells can migrate over regions devoid of support from extracellular matrix

A team of researchers from the National University of Singapore have discovered that outer skin cells are able to unite to form suspended "bridges" during wound healing. The new findings will pave the way for tissue engineering, such as the design of artificial skin, and better wound treatment.

13 Dec 2013

Spaceflights cause cellular-level damage and may lead to long-term vision problems

Those who travel to space are rewarded with a beautiful sight - planet Earth. But the effects of space travel on the human sense of sight aren't so beautiful. More than 30 percent of astronauts who returned from two-week space shuttle missions and 60 percent who spent six months aboard the International Space Station were diagnosed with eye problems. Two recent investigations examined mechanisms that may explain eye changes in spaceflight, help find ways to minimize this health risk to astronauts and eventually prevent and treat eye diseases on Earth.

13 Dec 2013

Polyunsaturated fatty acids play key role in embryonic development

One classical question in developmental biology is how different tissue types arise in the correct position of the developing embryo. While one signaling pathway that controls this process has been well described, unexpected findings from a team led by Carnegie's Steven Farber reveal the importance of polyunsaturated fatty acid metabolism in this process. It is published online December 12 in Developmental Cell.

13 Dec 2013

Dasatinib+letrozole improves survival for women with hormone receptor-positive, HER2-negative metastatic breast cancer

Adding the drug dasatinib to a standard antihormone therapy, letrozole, doubled the time before disease progressed for women with hormone receptor-positive, HER2-negative metastatic breast cancer, according to results of a phase II clinical trial presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.

13 Dec 2013

Transport of bacterial substrates through injectisome observed almost in real time

When attacking body cells, bacteria, such as salmonellae or Yersinia (plague pathogens), inject specific bacterial proteins through hollow, syringe-like structures - called injectisomes - into the host cells. These substances reprogram the cells and can thus overcome their defense. From then on, they can infiltrate the cells unhindered in large numbers, and trigger diseases such as typhus, plague, or cholera.

13 Dec 2013

Researchers uncover second rare genetic mutation linked to higher risk of Alzheimer's disease

A research team from The University of Nottingham has helped uncover a second rare genetic mutation which strongly increases the risk of Alzheimer's disease in later life.

13 Dec 2013

Researchers discover completely new targets for treatment of blood cancers

A particularly aggressive form of leukemia is the acute lymphoblastic leukemia (ALL). It is especially common among children and very difficult to treat. Researchers from the University of Veterinary Medicine, Vienna have now discovered completely new targets for the treatment of blood cancers.

13 Dec 2013

Protein in Salmonella inactivates mast cells that fight against bacteria

A protein in Salmonella inactivates mast cells -- critical players in the body's fight against bacteria and other pathogens -- rendering them unable to protect against bacterial spread in the body, according to researchers at Duke Medicine and Duke-National University of Singapore (Duke-NUS).

13 Dec 2013

Names of 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences unveiled

The names of the 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences were unveiled at an exclusive ceremony at the NASA Ames Research Center, Mountain View, CA. At a total awarded amount of $21 million, sponsored by Sergey Brin & Anne Wojcicki, Jack Ma & Cathy Zhang, Yuri & Julia Milner and Mark Zuckerberg & Priscilla Chan, the prizes aim to celebrate scientists and generate excitement about the pursuit of science as a career.

13 Dec 2013

New treatment options for diabetic wound healing in cornea and skin

Diabetes Mellitus (DM), a metabolic disorder that affects nearly 170 million people worldwide, is characterized by chronic hyperglycemia that disrupts carbohydrate fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. DM can cause long-term damage, dysfunction and even failure of various organs.

13 Dec 2013

Vaccines for whooping cough contain 3 to 5 protective antigens

Vaccines for whooping cough contain three to five protective antigens, the presence of which are critical to the vaccine's effectiveness. But one of the antigens, pertactin, which had been present in almost all isolates of Bordetella pertussis in the US as late as 2010, is now absent from more than half of them, according to a paper published ahead of print in Clinical and Vaccine Immunology.

13 Dec 2013

Protein C News and Research

Study could lead towards a personalised medicine for chemoresistant lymphomata

Four U.S. researchers to receive grants to improve cognition in individuals living with Down syndrome

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

Research reveals that deletion of Epac1 gene protects from fatal rickettsiosis

Scientists reveal how two genes interact to kill broad range of cancer cells

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

Researchers study zebrafish embryo skin to find link between low calcium and colon cancer

Researchers test promising new breast cancer drugs

New UCSF-led study links obesity to development of chronic kidney disease

Skin cells can migrate over regions devoid of support from extracellular matrix

Spaceflights cause cellular-level damage and may lead to long-term vision problems

Polyunsaturated fatty acids play key role in embryonic development

Dasatinib+letrozole improves survival for women with hormone receptor-positive, HER2-negative metastatic breast cancer

Transport of bacterial substrates through injectisome observed almost in real time

Researchers uncover second rare genetic mutation linked to higher risk of Alzheimer's disease

Researchers discover completely new targets for treatment of blood cancers

Protein in Salmonella inactivates mast cells that fight against bacteria

Names of 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences unveiled

New treatment options for diabetic wound healing in cornea and skin

Vaccines for whooping cough contain 3 to 5 protective antigens

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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