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Patients taking anti-depressants more likely to develop gastrointestinal bleeding

Patients taking anti-depressant medications classified as selective serotonin reuptake inhibitors are 40 percent more likely to develop severe gastrointestinal bleeding, particularly when they also use common over-the-counter pain relievers, according to a research review in the Journal of the American Osteopathic Association.

31 Jan 2019

Expediting HPLC Method Development in Pharmaceutical Analysis

In this interview, Michael Dong discusses stability-indicating methods such as UHPLC, in pharmaceutical analysis. At Pittcon, Michael will introduce a 3-pronged template approach to HPLC method development.

From Pittcon 30 Jan 2019

New drug compounds show promise in treating acute myeloid leukemia

Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.

29 Jan 2019

Scientists develop new method for synthesizing para-carboxyplenylsiloxanes

Russian scientists have developed a new method for synthesizing para-carboxyplenylsiloxanes, a unique class of organosilicon compounds. The resulting compounds are promising for creating self-healing, electrically conductive, heat- and frost-resistant silicones.

25 Jan 2019

Researchers demonstrate strong evidence connecting bacterial pathogen and Alzheimer's pathogenesisis

New science uncovers how an unlikely culprit, Porphyromonas gingivalis (Pg) - the bacterium commonly associated with chronic gum disease - appears to drive Alzheimer's disease (AD) pathology.

24 Jan 2019

Synthetic compound from flaxseed can improve heart function in mice with sepsis

Sepsis is a life-threatening systemic inflammatory condition that develops in response to infection. One of its major complications is cardiovascular dysfunction, in which deterioration of the heart muscle, driven by decreased energy production resulting from reduced oxygen and nutrient supplies, frequently ends in organ failure.

23 Jan 2019

Peptide isolated from soil fungi has antitumor and antibacterial properties

A team of scientists from I.M. Sechenov First Moscow State Medical University together with their colleagues isolated a peptide named emericellipsin A from soil fungi.

22 Jan 2019

Study describes metabolism of intestinal microbiota in babies for the first time

A research team with the participation of the Institute for Integrative Systems Biology of the University of Valencia, together with FISABIO and CIBERESP, has carried out the first metatranscriptomic study of the gut microbiota of babies, which has allowed to unveil the metabolism of the intestinal bacterial community during the first year of life, with a level of detail unknown until now

22 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Scientists reveal new mechanism that could lead to specific treatment of strokes and seizures

The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects.

21 Jan 2019

New anti-inflammatory compound acts as 'surge protector' to reduce cancer growth

A new anti-inflammatory compound developed at the University of California, Davis, acts as a "surge protector" to suppress inflammation and reduce cancer growth, at least in mouse models of cancer.

17 Jan 2019

Pre-injury exercise reduces damage to both muscles and nerves, study finds

Exercise can protect both muscle and nerves from damage caused by the restoration of blood flow after injury or surgery, new research from the University of Virginia School of Medicine shows.

17 Jan 2019

Hamilton Storage launches LabElite DeCapper SL to expand LabElite product family

Hamilton Storage introduces a new member of the LabElite product family with the launch of the LabElite DeCapper SL.

16 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Cancer is a multidisciplinary disease, with different mutations leading to different prognoses and treatment necessities. Among the most important mutation targets in cancers, affecting more than 50% of all cancer cases, is TP53.

14 Jan 2019

Study explains why some drugs work well in ameliorating side effects of chemotherapy

Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy.

10 Jan 2019

Microbial metabolite from pomegranates can reduce and protect against IBD

Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease.

10 Jan 2019

Chemical in sunscreen and cosmetics may harm coral by altering fatty acids

Although sunscreen is critical for preventing sunburns and skin cancer, some of its ingredients are not so beneficial to ocean-dwelling creatures. In particular, sunscreen chemicals shed by swimmers are thought to contribute to coral reef decline.

9 Jan 2019

Mechanism underlying impaired allergic inflammation in children may explain hygiene hypothesis

The hygiene hypothesis may explain why asthma and other allergic airway diseases have dramatically increased over the past decades in industrialized countries.