B Cell News and Research

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Three-dimensional organization of genome plays key role in gene expression, cell fate

Scientists have long been reading the code of life - the genome -, as a sequence of letters but now researchers have also started exploring its three-dimensional organization.

17 Jan 2018

Scientists identify six new gene regions that may help treat type 1 diabetes

Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it.

17 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

A new strategy proposed for drug discovery

A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime.

17 Jan 2018

Research: Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancer

Cleveland Clinic researchers have confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, treatment-resistant prostate cancer.

17 Jan 2018

Scientists develop unique technique to map elasticity of cell components

Scientists at Université de Montréal have developed a unique technique to map, on a scale of milliseconds, the elasticity of the components inside a cell.

17 Jan 2018

Bile acids: A new therapy against obesity

Obesity arises from an imbalance between energy intake and energy expenditure. As a result, current treatments try to decrease calorie intake and/or increase energy expenditure.

17 Jan 2018

Fast food triggers the immune system making it hyperactive

The immune system has been shown to react to fast foods containing excess salt and calories find researchers. This activation of the immune system to fast foods is similar to its reaction to bacterial infections they add.

16 Jan 2018

How fatal mitochondrial diseases may strike offspring of families with no history of the conditions

Researchers from the Medical Research Council (MRC) have discovered how some children inherit a potentially life-threatening mitochondrial disease, despite being born to a healthy mother.

16 Jan 2018

Bile acids could directly burn away lipids in the fat depots

The EPFL scientists discovered that bile acids can turn fat-storing cells into fat-burning ones. This process is called thermogenesis (literally, "heat production") and it helps maintain body temperature in cold environments.

16 Jan 2018

Penn scientists identify new therapeutic target for treatment of melanoma

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma.

16 Jan 2018

Applied math can help predict genesis and evolution of different cancers

Applied mathematics can be a powerful tool in helping predict the genesis and evolution of different types of cancers, a study from the University of Waterloo has found.

16 Jan 2018

Study reveals new diabetes gene in families with rare blood sugar conditions

A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

16 Jan 2018

FDA grants approval for first drug to treat inherited breast cancer

The U.S. Food and Drug Administration today expanded the approved use of Lynparza (olaparib tablets) to include the treatment of patients with certain types of breast cancer that have spread (metastasized) and whose tumors have a specific inherited (germline) genetic mutation, making it the first drug in its class (PARP inhibitor) approved to treat breast cancer, and it is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a "BRCA" gene mutation.

15 Jan 2018

Scientists describe groundbreaking training effect on the innate immune system

"Training" of precursors of white blood cells leads to a sustained positive response of the hematopoietic system. This effect could help accelerate the formation of new white blood cells, which are vitally needed during chemotherapy, a process that can slow down hematopoiesis.

15 Jan 2018

Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

Immunologists and oncologists are harnessing the body's immune system to fight cancers and other diseases with adoptive cell transfer techniques. In a normal immune response, a type of white blood cell known as T cells are instructed by another kind of immune cell called an antigen-presenting cell (APC) to expand their numbers and stay alive.

15 Jan 2018