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Stem cell transplant improves survival among scleroderma patients

Scleroderma with internal organ involvement is a debilitating and lethal autoimmune disorder with few effective treatments. But a study led by Duke Health researchers has found new cause for optimism using an aggressive stem cell transplant regimen.

5 Jan 2018

Newly described super-silenced DNA reveals novel approach to reprogram cells

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study in Molecular Cell last week by investigators from the Perelman School of Medicine at the University of Pennsylvania.

5 Jan 2018

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Disorders caused by a leaky vasculature are more common than most people think. Despite ICU treatment, one third of the 27 million patients globally that suffer from sepsis, and up to 20% of the more than 5 million US patients with congestive heart failure die every year from their condition.

5 Jan 2018

Cellular mechanism protects genes from damaging effects of mutation

Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.

5 Jan 2018

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis.

5 Jan 2018

Researchers use genomic technologies to better understand risk factor for stomach cancer

A research team led by National University Health System and Duke-NUS Medical School has used genomic technologies to better understand intestinal metaplasia, a known risk factor for gastric (stomach) cancer.

5 Jan 2018

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

In the Jan. 5, 2018 issue of Science, researchers from the University of Chicago Medicine show that specific strains of commensal bacteria – the swarms of microorganisms naturally dwelling in the intestines – can improve the response rate to immunotherapy for patients being treated for advanced melanoma.

5 Jan 2018

Researchers discover genetic mechanism for resistance to immunotherapy drugs

An urgent question for cancer scientists is why immunotherapy achieves dramatic results in some cases but doesn't help most patients.

5 Jan 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018

Newly identified germline variations increase risk of relapse or second cancers in leukemia patients

Newly identified germline variations in a key tumor suppressor gene predispose individuals to develop leukemia as children and leave them with a 1-in-4 chance of developing a second cancer later. St. Jude Children's Research Hospital scientists led the study, which appears today in the Journal of Clinical Oncology.

5 Jan 2018

UC Davis expert expresses caution on genetically engineered HSCs

In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death during transplantation.

4 Jan 2018

Study provides insight into how early-stage breast cancer progresses to invasive ductal carcinoma

A new genetic-based model may explain how a common form of early-stage breast cancer known as ductal carcinoma in situ progresses to a more invasive form of cancer say researchers at The University of Texas MD Anderson Cancer Center.

4 Jan 2018

Popular contraceptive shot may raise risk of HIV infection

Transitioning away from a popular contraceptive shot known as DMPA could help protect women in Sub-Saharan Africa and other high-risk regions from becoming infected with HIV, according to a research review published in the Endocrine Society's journal Endocrine Reviews.

4 Jan 2018

Researchers discover promising drug that shrinks excess fat without lowering food intake

Given the ever-increasing obesity epidemic, researchers from The University of Texas Medical Branch at Galveston have discovered a promising developing drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism.

4 Jan 2018

Soil-dwelling bacterium produces potential weapon against melanoma

A type of soil-dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows.

4 Jan 2018

MGH study points toward potential strategy for treating X-linked disorders

A study from a team of Massachusetts General Hospital (MGH) investigators points toward a potential strategy for treating X-linked disorders - those caused by mutations in the X chromosome - in females.

4 Jan 2018

Small-cell lung cancer patients encounter obstacles to receiving standard-of-care treatment

Despite decades of clinical research establishing chemotherapy with thoracic radiation as the standard-of-care for the initial management of non-metastatic small-cell lung cancer (SCLC), a large percentage of U.S. patients do not receive these treatments and in turn have lower overall survival, according to research from The University of Texas MD Anderson Cancer Center.

4 Jan 2018

B Cell News and Research

Stem cell transplant improves survival among scleroderma patients

Newly described super-silenced DNA reveals novel approach to reprogram cells

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Cellular mechanism protects genes from damaging effects of mutation

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

Researchers use genomic technologies to better understand risk factor for stomach cancer

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

Researchers discover genetic mechanism for resistance to immunotherapy drugs

Why Should We Weigh Every Protein in the Human Body?

Newly identified germline variations increase risk of relapse or second cancers in leukemia patients

UC Davis expert expresses caution on genetically engineered HSCs

Study provides insight into how early-stage breast cancer progresses to invasive ductal carcinoma

Popular contraceptive shot may raise risk of HIV infection

Researchers discover promising drug that shrinks excess fat without lowering food intake

Soil-dwelling bacterium produces potential weapon against melanoma

MGH study points toward potential strategy for treating X-linked disorders

Small-cell lung cancer patients encounter obstacles to receiving standard-of-care treatment

Phase III clinical study of regenerative therapy for treating damaged cartilage has started

Study finds new brainstem changes in Parkinson’s disease

Researchers describe key cellular receptor involved in ovarian cancer metastasis

Using single B cell screening to boost antibody discovery eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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