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Researchers identify natural protective factor against chronic inflammation in diabetes patients

In type 2 diabetes, chronic inflammation drives cardiovascular disease, the leading cause of death among people with the condition. Researchers at Joslin Diabetes Center now have identified an unexpected natural protective factor that works against this inflammation.

20 Sep 2017

Scientists genetically engineer mice that display behavioral hallmarks of human bipolar disorder

Johns Hopkins researchers report they have genetically engineered mice that display many of the behavioral hallmarks of human bipolar disorder, and that the abnormal behaviors the rodents show can be reversed using well-established drug treatments for bipolar disorder, such as lithium.

18 Sep 2017

University Of Minnesota scientists describe breakthrough in research related to FSHD

A new study published in the journal Nature Communications describes a breakthrough in research related to facioscapulohumeral muscular dystrophy (FSHD). The debilitating genetic disease - which has no approved treatment - affects an estimated 38,000 Americans and causes degeneration and wasting of the skeletal muscles.

15 Sep 2017

Study shows how regular exercise, stress reduction could lead to better health in lupus patients

Waking up in the morning with the joint pain, swelling and stiffness that accompanies lupus doesn't exactly inspire a workout.

14 Sep 2017

Brain activity found to be perturbed between seizures in childhood absence epilepsy

New research shows that in a mouse model of childhood absence epilepsy, brain activity is perturbed between seizures. The researchers speculate that this could underlie cognitive problems of the disease, which can persist despite treatment of seizures.

14 Sep 2017

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.

13 Sep 2017

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

For a cancer drug to be successful, it needs to reach the malignant tumor site. Researchers in Japan have now found a way for increasing the effectiveness of drug delivery to certain types of brain tumors, by packing epirubicin, a known antitumor agent, in specially designed polymeric micelles.

13 Sep 2017

Component of fire ant venom shows promise as a psoriasis treatment

In a new study involving laboratory mice, researchers have found that solenopsin and similar compounds could be beneficial for psoriasis.

11 Sep 2017

Compounds derived from fire ant venom could lead to new anti-psoriasis therapy

Compounds derived from fire ant venom can reduce skin thickening and inflammation in a mouse model of psoriasis, Emory and Case Western scientists have shown.

11 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders.

5 Sep 2017

Traditional Chinese herb may hold key to new osteoporosis therapy for preventing bone loss

An herb widely used in traditional Chinese medicine might hold the key to a new osteoporosis therapy that could prevent bone loss without causing side effects.

29 Aug 2017

Research findings potentially open door to new treatments for eye trauma and retinal disease

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows. The findings potentially open the door to new treatments for eye trauma and retinal disease.

28 Aug 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

New drug shows promising results for treating spinal muscular atrophy

A drug developed by an Iowa State University biomedical researcher as a potential treatment for spinal muscular atrophy showed promising results in a recently published study.

26 Aug 2017

Studies aim to better understand potential health benefits of red raspberries

Initial findings from several studies - including both human subjects and animals - on the potential health benefits of red raspberries were presented earlier this year at the 2017 Experimental Biology conference in Chicago.

24 Aug 2017

Discovery sheds new light on biological phenomenon in autoimmune disease

A newly-unveiled discovery, which has been four years in the making, has the potential to change the way we look at autoimmune diseases and understand how and why immune cells begin to attack different tissues in the body.

24 Aug 2017

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Having twice the normal amount of the protein MeCP2, a condition called MECP2 duplication syndrome, causes severe progressive neuropsychiatric disorders that include intellectual disability, autism spectrum disorders, motor dysfunction and other medical complications.

24 Aug 2017

Researchers use small molecule to relieve symptoms of Rett syndrome in mouse model

Vanderbilt University researchers have relieved symptoms of Rett syndrome in a mouse model with a small molecule that works like the dimmer switch in an electrical circuit.

23 Aug 2017

Study findings could one day help doctors better predict survival of liver cancer patients

A new study of a molecule that regulates liver-cell metabolism and suppresses liver-cancer development shows that the molecule interacts with thousands of genes in liver cells, and that when levels of the molecule go down, which often happens during liver-cancer development, the activity of certain cancer-promoting genes goes up.

23 Aug 2017

Mouse Model News and Research

Researchers identify natural protective factor against chronic inflammation in diabetes patients

Scientists genetically engineer mice that display behavioral hallmarks of human bipolar disorder

University Of Minnesota scientists describe breakthrough in research related to FSHD

Study shows how regular exercise, stress reduction could lead to better health in lupus patients

Brain activity found to be perturbed between seizures in childhood absence epilepsy

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

Component of fire ant venom shows promise as a psoriasis treatment

Compounds derived from fire ant venom could lead to new anti-psoriasis therapy

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

Traditional Chinese herb may hold key to new osteoporosis therapy for preventing bone loss

Research findings potentially open door to new treatments for eye trauma and retinal disease

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

New drug shows promising results for treating spinal muscular atrophy

Studies aim to better understand potential health benefits of red raspberries

Discovery sheds new light on biological phenomenon in autoimmune disease

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Researchers use small molecule to relieve symptoms of Rett syndrome in mouse model

Study findings could one day help doctors better predict survival of liver cancer patients

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