Mouse Model News and Research

RSS

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

A study by scientists at the Children's Medical Center Research Institute at UT Southwestern is providing insight into the genetic basis of neuropsychiatric disorders.

21 Jul 2017

Researchers show how hematopoietic stem cells detect and react to infections

Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide - that is, without signals from growth factors.

20 Jul 2017

Lunatic fringe gene plays role in regulating fate of neural stem cells

The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated.

19 Jul 2017

MGH researchers identify novel mechanism behind resistance to angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a novel mechanism behind resistance to angiogenesis inhibitors - drugs that fight cancer by suppressing the formation of new blood vessels.

14 Jul 2017

Cellular antennae play key role in muscle-to-fat transformation

Like it or not, as we age, our muscle cells are slowly exchanged, one by one, for fat cells. This process quickens when we injure a muscle, and an extreme form of this process is also seen in muscle-wasting diseases such as Duchenne muscular dystrophy (DMD).

13 Jul 2017

Potential vaccines could protect developing fetus from Zika virus, UTMB study shows

Immunizing female mice with a Zika vaccine can protect their developing fetus from infection and birth defects during pregnancy, according to new research from The University of Texas Medical Branch at Galveston.

13 Jul 2017

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia.

13 Jul 2017

MPFI researchers reveal new technique to probe function of cerebellar interneurons

The cerebellum is an area of brain at the back of your head involved in movement. Its neuronal circuitry is relatively simple compared to other areas, but scientists still have a lot left to learn regarding its role in motor control and motor learning.

13 Jul 2017

Diabetes-induced changes in oral microbiome promote periodontal bone loss

A new study led by University of Pennsylvania researchers has found that the oral microbiome is affected by diabetes, causing a shift to increase its pathogenicity.

12 Jul 2017

ERYTECH partners with Queen’s University to advance its product candidate for treating arginase-1 deficiency

ERYTECH Pharma, a French clinical-stage biopharmaceutical company developing innovative therapies for rare forms of cancer and orphan diseases, today announced that it has entered into a research collaboration with Queen's University in Canada to advance the preclinical development of ERYTECH's eryminase program specifically for the treatment of arginase-1 deficiency, a rare and severe metabolic disorder related to arginine metabolism.

12 Jul 2017

New study links hepatic inflammation to western diet

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males. Moreover, liver inflammation was most pronounced in Western diet-fed male mice that also lacked farnesoid x receptor (FXR), a bile acid receptor.

12 Jul 2017

Antibiotic use during peripartum period linked to greater risk of inflammatory condition in offspring

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

11 Jul 2017

Scientists develop potential new therapy for targeting skin cancer metastases in the brain

Investigators from Brigham and Women's Hospital (BWH) and the Harvard Stem Cell Institute have a potential solution for how to kill tumor cells that have metastasized to the brain.

10 Jul 2017

Maternal consumption of alcohol could produce transgenerational effects

Soon-to-be mothers have heard the warning - don't drink while pregnant. The Centers for Disease Control and Prevention has issued numerous statements about the dangers of alcohol consumption during pregnancy, as it can lead to Fetal Alcohol Spectrum Disorders (FASD) in newborns.

7 Jul 2017

Corticosteroids may worsen disease in some patients with severe asthma

Researchers from the University of Pittsburgh Schools of the Health Sciences and UPMC have uncovered the molecular mechanism underlying corticosteroid resistance in severe asthma.

6 Jul 2017

Sialic acid found in animals protects farm children from asthma

It is a known fact that microbes on farms protect children from asthma and allergies. But even non-microbial molecules can have a protective effect: Immunologists from the University of Zurich have shown that a sialic acid found in farm animals is effective against inflammation of lung tissue.

6 Jul 2017

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during a randomized, double blind, placebo-controlled clinical trial, report University of California San Diego School of Medicine and University of Michigan researchers.

5 Jul 2017

Mouse Model News and Research

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

Researchers show how hematopoietic stem cells detect and react to infections

Lunatic fringe gene plays role in regulating fate of neural stem cells

MGH researchers identify novel mechanism behind resistance to angiogenesis inhibitors

Cellular antennae play key role in muscle-to-fat transformation

Potential vaccines could protect developing fetus from Zika virus, UTMB study shows

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

MPFI researchers reveal new technique to probe function of cerebellar interneurons

Diabetes-induced changes in oral microbiome promote periodontal bone loss

ERYTECH partners with Queen’s University to advance its product candidate for treating arginase-1 deficiency

New study links hepatic inflammation to western diet

Antibiotic use during peripartum period linked to greater risk of inflammatory condition in offspring

Scientists develop potential new therapy for targeting skin cancer metastases in the brain

Maternal consumption of alcohol could produce transgenerational effects

Corticosteroids may worsen disease in some patients with severe asthma

Sialic acid found in animals protects farm children from asthma

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

Mitochondria-targeted antioxidant shows promise for diabetic wound treatment

New antiviral drug candidate effective against broad range of coronaviruses

Mouse brain models reveal insights into genetics of autism

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News