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NHCS researchers discover potential cure for long QT syndrome 2

The National Heart Centre Singapore research team has successfully and completely reversed the effects of the hERG (human ether-a-go-go-related gene) mutation in long QT syndrome 2 in patient-specific heart cells, scoring a world's first.

18 Sep 2013

Study: Mesenchymal stem cell transplantation may help treat stress urinary incontinence

Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence", a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective.

18 Sep 2013

Cleveland Clinic creates spin-off company to develop vaccine for preventing breast cancer

Cleveland Clinic Innovations has created a spin-off company to develop a preventive breast cancer vaccine based on research from Cleveland Clinic's Lerner Research Institute.

18 Sep 2013

RedHill Biopharma to initiate phase III trial of RHB 104 in Crohn's disease patients

UCF College of Medicine professor Dr. Saleh Naser soon will participate in a clinical trial to test whether a new antibiotic therapy acquired by RedHill Biopharma can be used to treat Crohn's disease patients.

18 Sep 2013

Abnormalities in brain axons predispose people to chronic back pain after injury

Abnormalities in the structure of the brain predispose people to develop chronic pain after a lower back injury, according to new Northwestern Medicine- research. The findings could lead to changes in the way physicians treat patients' pain.

18 Sep 2013

FDA grants Breakthrough Therapy designation to Boehringer Ingelheim's volasertib

Boehringer Ingelheim Pharmaceuticals, Inc. today announced the FDA has granted Breakthrough Therapy designation to volasertib, an investigational inhibitor of polo-like kinase, being evaluated for the treatment of patients aged 65 or older with previously untreated acute myeloid leukemia, ineligible for intensive remission induction therapy.

17 Sep 2013

Regado Biosciences announces enrollment of first patient in REGULATE-PCI clinical trial

Regado Biosciences, Inc., a biopharmaceutical company focused on the discovery and development of novel, first-in-class, actively controllable antithrombotic drug systems for acute and sub-acute cardiovascular indications, today announced the enrollment of the first patient in its REGULATE-PCI clinical trial.

17 Sep 2013

Acacia Pharma initiates two pivotal Phase 3 studies of APD421 in prevention of PONV

Acacia Pharma, a pharmaceutical company specialising in the development of drugs for supportive care, announces the initiation of two pivotal Phase 3 studies of APD421 in the prevention of post-operative nausea & vomiting (PONV).

17 Sep 2013

Immune marker predicts transplant success, improves selection of bone marrow donors

The risk of death following bone marrow transplantation can be reduced about 60 percent using a new technique to identify bone marrow donors who make the most potent cancer-fighting immune cells, according to research from St. Jude Children's Research Hospital. The findings appear in the September 16 online issue of the Journal of Clinical Oncology.

17 Sep 2013

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

The National Institute of Environmental Health Sciences (NIEHS) has awarded a five-year, $1.5 million grant extension to Columbia University's Mailman School of Public Health to fund research into the function of a biomarker for brain injury called Translocator Protein 18 kDa, better known as TSPO, in order to better understand its function in brain injury and inflammation and discover targets for therapy.

17 Sep 2013

State highlights: Analysis finds no imminent patient danger before Texas abortion law; N.M. fraud investigation disrupts mental health care

In their successful push this summer for strict new regulations on abortion facilities and the doctors performing them, proponents said the legislation was needed because conditions at existing facilities made it unsafe for women seeking to terminate pregnancies. But a Texas Tribune review of state inspection records for 36 abortion clinics from the year preceding the lawmakers' vote turned up little evidence to suggest that the facilities were putting patients in imminent danger.

17 Sep 2013

Researchers identify potentially treatable subtype of pancreatic cancer

Australian researchers have identified a potentially treatable subtype of pancreatic cancer, which accounts for about 2% of new cases. This subtype expresses high levels of the HER2 gene. HER2-amplified breast and gastric cancers are currently treated with Herceptin.

17 Sep 2013

FDA issues import alert on drug products manufactured at Ranbaxy's facility in Mohali, India

The U.S. Food and Drug Administration today issued an import alert under which U.S. officials may detain at the U.S. border drug products manufactured at Ranbaxy Laboratories, Ltd.'s facility in Mohali, India.

17 Sep 2013

Overexpression of cytoglobin gene inhibits hypoxic injury to neuroblastoma cells

Cytoglobin is a temporary oxygen reservoir, which might provide a minimal, but continuous supply of intracellular oxygen during ischemic and anoxic conditions.

17 Sep 2013

Oxytocin shows evidence of therapeutic value for autism, schizophrenia

The hormone oxytocin could play a role in treating psychiatric disorders such as autism and schizophrenia, according to a review article in the September Harvard Review of Psychiatry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

17 Sep 2013

Arginine therapy may be safe treatment for patients with sickle cell disease

Arginine therapy may be a safe and inexpensive treatment for acute pain episodes in patients with sickle cell disease, according to results of a recent clinical study. The study was the first randomized placebo-controlled study to demonstrate benefits of arginine therapy in children with sickle cell disease hospitalized for severe pain.

17 Sep 2013

Case for targeting perfectionism in patients with bipolar disorder

Anxiety and stress symptoms may mediate the association between perfectionism and depressive symptoms in patients with bipolar disorder in a “transdiagnostic” process, say researchers.

16 Sep 2013

Studying Tumor Mutations Via A Network Approach

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16 Sep 2013

Smoking-cessation in HIV-positive individuals: an interview with Dr Ellen R. Gritz, University of Texas MD Anderson Cancer Center

In the general population, current smoking prevalence is 18%. Persons living with HIV/AIDS smoke at a rate 2 to 3 times higher, up to almost 70% in some studies.

16 Sep 2013

Affimed Therapeutics, LLS partner to co-fund AFM13 phase 2 trial for treatment of Hodgkin Lymphoma

Affimed Therapeutics AG and The Leukemia & Lymphoma Society today announced a partnership to co-fund a phase 2 trial with the Recruit-TandAb AFM13, a novel tetravalent bispecific antibody directed against human CD30 and CD16A in Hodgkin Lymphoma patients for whom currently available treatments have failed.

16 Sep 2013

Therapy News and Research

NHCS researchers discover potential cure for long QT syndrome 2

Study: Mesenchymal stem cell transplantation may help treat stress urinary incontinence

Cleveland Clinic creates spin-off company to develop vaccine for preventing breast cancer

RedHill Biopharma to initiate phase III trial of RHB 104 in Crohn's disease patients

Abnormalities in brain axons predispose people to chronic back pain after injury

FDA grants Breakthrough Therapy designation to Boehringer Ingelheim's volasertib

Regado Biosciences announces enrollment of first patient in REGULATE-PCI clinical trial

Acacia Pharma initiates two pivotal Phase 3 studies of APD421 in prevention of PONV

Immune marker predicts transplant success, improves selection of bone marrow donors

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

State highlights: Analysis finds no imminent patient danger before Texas abortion law; N.M. fraud investigation disrupts mental health care

Researchers identify potentially treatable subtype of pancreatic cancer

FDA issues import alert on drug products manufactured at Ranbaxy's facility in Mohali, India

Overexpression of cytoglobin gene inhibits hypoxic injury to neuroblastoma cells

Oxytocin shows evidence of therapeutic value for autism, schizophrenia

Arginine therapy may be safe treatment for patients with sickle cell disease

Case for targeting perfectionism in patients with bipolar disorder

Studying Tumor Mutations Via A Network Approach

Smoking-cessation in HIV-positive individuals: an interview with Dr Ellen R. Gritz, University of Texas MD Anderson Cancer Center

Affimed Therapeutics, LLS partner to co-fund AFM13 phase 2 trial for treatment of Hodgkin Lymphoma

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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