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Combination drug does not improve survival in patients with severe alcoholic hepatitis

Four weeks of treatment with a combination of the drug pentoxifylline and the corticosteroid prednisolone did not improve 6-month survival compared with prednisolone alone in 270 patients with severe alcoholic hepatitis, according to a study in the September 11 issue of JAMA.

11 Sep 2013

Personalized treatment may be effective in wild type cancers

As a woman in her mid-forties who didn't smoke, Elizabeth Lacasia never expected to be diagnosed with lung cancer. But in 2006, after she developed a persistent and serious cough, a chest X-ray and CT scan revealed several tumors in her lower left lung.

11 Sep 2013

Research finding could lead to better solutions for cancer, anti-viral treatments

Medical scientists at the University of Alberta have made a key discovery about how the immune system kills healthy cells while attacking infections. This finding could one day lead to better solutions for cancer and anti-viral treatments.

11 Sep 2013

New bill allows Californians to directly access physical therapist services

California's Senate passed AB 1000 (Wieckowski/Maienschein) to allow Californians to directly access physical therapist services. The bill passed off the Senate Floor and now goes back to the Assembly to approve amendments before heading to the Governor's desk.

11 Sep 2013

Researchers discover 4 novel gene variations linked with blood pressure

Case Western Reserve University is part of a landmark study that has discovered four novel gene variations associated with blood pressure. The 19-site meta-analysis, involving nearly 30,000 African-Americans, also found that the set of genetic mutations are also associated with blood pressure across other populations.

11 Sep 2013

New strategy to reduce central line-associated bloodstream infections

Simply replacing the connector in the IV system in patients with central lines could help reduce deadly bloodstream infections, researchers at Georgia Regents University have found.

11 Sep 2013

Discovery opens doors for developing new therapies to eradicate tumor cells, combat infections

Scientists from A*STAR's Singapore Immunology Network have discovered a new defense mechanism that the immune system utilises to combat infections. The team's discovery of how a novel protein unexpectedly activates an immune response shows how this mechanism can also be used to get rid of tumour cells.

11 Sep 2013

Astrazeneca, Hadasit Launch Drug Discovery Alliance

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10 Sep 2013

MJFF awards $1.35M to Rhythm for Phase 2 clinical trial of RM-131 for Parkinson's disease

Rhythm announced today that The Michael J. Fox Foundation for Parkinson's Research has awarded a $1.35 million research grant to Rhythm to help fund a Phase 2 clinical trial of RM-131, the company's novel ghrelin agonist, for the treatment of refractory constipation in patients with Parkinson's disease.

10 Sep 2013

Boehringer Ingelheim completes patient enrolment for interferon-free hepatitis C treatment

Boehringer Ingelheim today announced the completion of patient enrolment for a Phase IIa clinical trial investigating a new interferon-free, all-oral, direct-acting antiviral combination treatment for patients with genotype-1a chronic hepatitis C virus infection.

10 Sep 2013

Hospira announces EC approval of Inflectra, Europe's first biosimilar mAb therapy

Hospira, the world's leading provider of injectable drugs and infusion technologies, today announced the European Commission (EC) approval of Inflectra™ (infliximab), Europe's first biosimilar monoclonal antibody (mAb) therapy. Inflectra has been approved for the treatment of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), ulcerative colitis (UC), psoriatic arthritis (PsA) and psoriasis.

10 Sep 2013

Metamark reports positive results from clinical validation study of prostate cancer prognostic test

Metamark Genetics, Inc., a privately-held biotechnology company, today announced positive results from a large clinical validation study of ProMark, its biopsy-based prostate cancer prognostic test.

10 Sep 2013

Researchers assess prevalence, cost of critical care therapies seen as futile by doctors

In one of the first studies of its kind, a joint UCLA/RAND Corporation study addressed the prevalence and cost of critical care therapies provided in intensive care units that were perceived by physicians as "futile."

10 Sep 2013

GIQuIC expands endoscopic quality registry to include upper GI endoscopy

The GI Quality Improvement Consortium announces the expansion of its endoscopic quality registry to include upper GI endoscopy and related quality measures. GIQuIC, a quality benchmarking registry co-sponsored by the American College of Gastroenterology and the American Society for Gastrointestinal Endoscopy, provides reliable and relevant measures of endoscopic quality that give physicians meaningful information they can use to improve patient care.

10 Sep 2013

Combination of 2 antiviral drugs improves outcome in monkey model of MERS-CoV infection

National Institutes of Health (NIH) scientists report that a combination of two licensed antiviral drugs reduces virus replication and improves clinical outcome in a recently developed monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.

10 Sep 2013

Novel viral therapy to treat specific types of cancer in children

Parents do everything they can to protect their children against all of the nasty germs floating around classrooms across the country this time of year. Doctors and researchers at Nationwide Children's Hospital, however, are looking into how those same types of common viruses can actually help treat a child who is diagnosed with certain cancers.

10 Sep 2013

Biologists identify two pathways via which chromosomes are rearranged

Biologists reported today in Nature that they have identified two pathways through which chromosomes are rearranged in mammalian cells. These types of changes are associated with some cancers and inherited disorders in people.

10 Sep 2013

Most patients who report statin intolerance can actually tolerate drugs on subsequent trials

Most patients who report statin intolerance, including muscle aches and other side effects from the cholesterol-lowering drugs, can actually tolerate drugs from this class on subsequent trials, according to research from Cleveland Clinic recently released online and forthcoming in the September issue of the American Heart Journal. The study is the largest ever to examine the effects of re-challenging statin-intolerant patients.

10 Sep 2013

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

A little STING could go a long way in helping treat or even avoid autoimmune diseases such as arthritis, type 1 diabetes and multiple sclerosis, researchers report.

10 Sep 2013

Focusing on mental health key to improving physical health in teens: Study

Adding a mental health component to school-based lifestyle programs for teens could be key to lowering obesity, improving grades, alleviating severe depression and reducing substance use, a new study suggests.

10 Sep 2013

Therapy News and Research

Combination drug does not improve survival in patients with severe alcoholic hepatitis

Personalized treatment may be effective in wild type cancers

Research finding could lead to better solutions for cancer, anti-viral treatments

New bill allows Californians to directly access physical therapist services

Researchers discover 4 novel gene variations linked with blood pressure

New strategy to reduce central line-associated bloodstream infections

Discovery opens doors for developing new therapies to eradicate tumor cells, combat infections

Astrazeneca, Hadasit Launch Drug Discovery Alliance

MJFF awards $1.35M to Rhythm for Phase 2 clinical trial of RM-131 for Parkinson's disease

Boehringer Ingelheim completes patient enrolment for interferon-free hepatitis C treatment

Hospira announces EC approval of Inflectra, Europe's first biosimilar mAb therapy

Metamark reports positive results from clinical validation study of prostate cancer prognostic test

Researchers assess prevalence, cost of critical care therapies seen as futile by doctors

GIQuIC expands endoscopic quality registry to include upper GI endoscopy

Combination of 2 antiviral drugs improves outcome in monkey model of MERS-CoV infection

Novel viral therapy to treat specific types of cancer in children

Biologists identify two pathways via which chromosomes are rearranged

Most patients who report statin intolerance can actually tolerate drugs on subsequent trials

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

Focusing on mental health key to improving physical health in teens: Study

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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