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Selective androgen receptor modulator has anti-tumor effects in ER-positive breast cancer patients

A research paper published today (8 February 2024) in The Lancet Oncology demonstrates that the drug enobosarm, a selective androgen receptor modulator which stimulates the male sex hormone receptor has anti-tumour effects in estrogen receptor positive breast cancer patients.

8 Feb 2024

New cervical cancer detection method promises to reduce unnecessary screenings

The BMC Medicine study introduces the CerMe detection method, using PCDHGB7 hypermethylation to effectively triage high-risk HPV-positive women, potentially reducing unnecessary colposcopy referrals.

8 Feb 2024

Intravenous DMT shows promise in reducing depression symptoms, study reveals

A study in Scientific Reports shows intravenous DMT can significantly reduce depression severity in healthy volunteers, highlighting its potential as a therapeutic psychedelic intervention for mental health disorders.

8 Feb 2024

AI's ability to detect COVID-19 from coughs faces real-world challenges

A Nature Machine Intelligence study reveals that while AI classifiers can predict COVID-19 from audio recordings, their effectiveness diminishes when accounting for confounding factors, highlighting the challenges in applying AI diagnostics in real-world settings.

8 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

A new research perspective was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma."

8 Feb 2024

Flat positioning may give stroke patients an edge before surgery

Positioning patients with large vessel ischemic (clot-caused) stroke with their heads flat (0-degrees) before surgery to remove the blood clot resulted in significant improvements in neurological function, compared to patients whose heads were elevated (at a 30-degree angle), according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2024.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

7 Feb 2024

Teledermatology study exposes skin tone diagnosis gaps, AI offers improvement

Specialized and general physicians show significant gaps in diagnosing skin diseases across skin tones, with deep learning assistance improving accuracy but also highlighting disparities.

7 Feb 2024

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

AMG 133, an engineered bispecific molecule, demonstrated significant weight loss with a favorable safety profile in a phase 1 clinical trial, offering a promising new treatment option for obesity.

7 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024

SPOC Proteomics announces new product launch at SLAS2024

SPOC Proteomics, Inc, a deep-tech life sciences company based out of Scottsdale Arizona (HQ) and Menlo Park California, announced the commercial launch of their customizable sensor-integrated proteome on chip (SPOC®) biosensors for limited beta testing at SLAS2024.

From SPOC Proteomics 7 Feb 2024

Researchers uncover how deadly MRSA pneumonia inhibits body's antimicrobial activity

Researchers examined how heparan sulfate (HS) shedding impacts cathelicidin efficacy in Methicillin-Resistant Staphylococcus aureus (MRSA) pneumonia.

7 Feb 2024

Can ChatGPT outperform an expert in answering questions about colorectal cancer?

The proficiency of ChatGPT in answering questions related to colorectal cancer (CRC).

7 Feb 2024

AI helps predict antidepressant response in a week

In patients with major depression disorder it is, thanks to use of artificial intelligence, now possible to predict within a week whether an antidepressant will work.

7 Feb 2024

What natural compounds can help you manage your rosacea?

Researchers reviewed existing data on rosacea management using botanicals.

7 Feb 2024

New study highlights AI's potential to transform lung cancer screening

Artificial intelligence (AI) potential in early lung cancer detection.

7 Feb 2024

IVF add-on may be expensive, invasive, and ineffective, study finds

One of the most common add-ons to IVF procedures undertaken in Australia and globally by infertile couples may be a waste of time as well as expensive and invasive, and may even reduce the chances of success, according to a new report in The Lancet.

6 Feb 2024

Promising influenza drug candidate shows activity against resistant variants

Influenza A viruses with induced resistance to a new candidate antiviral drug were found to be impaired in cell culture and weakened in animals, according to a study by researchers in the Center for Translational Antiviral Research at Georgia State University.

6 Feb 2024