Malignant News and Research

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TSRI scientists receive NIH grant to create new drug for chronic lymphocytic leukemia

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded more than $1.4 million from the National Cancer Institute of the National Institutes of Health to create a potential new drug to attack the malignant cells that cause chronic lymphocytic leukemia (CLL), which is the most common leukemia in the Western world.

20 Jun 2013

Ibrutinib shows remarkable promise for treatment of mantle cell lymphoma

In a major international study led by researchers at The University of Texas MD Anderson Cancer Center, the targeted therapy ibrutinib continues to show remarkable promise for the treatment of relapsed or refractory mantle cell lymphoma (MCL).

20 Jun 2013

Results of ibrutinib Phase 2 study in patients with mantle cell lymphoma published in NEJM

Pharmacyclics, Inc. today announced that The New England Journal of Medicine published results of a Phase 2 study evaluating the investigational oral Bruton's tyrosine kinase inhibitor ibrutinib in patients with relapsed/refractory mantle cell lymphoma online.

20 Jun 2013

Stress exposure may be associated with increased risk of aggressive breast cancer

Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of breast cancer, researchers from the University of Chicago report in the July 2013 issue of the journal Cancer Prevention Research.

19 Jun 2013

Aspirin slows accumulation of DNA mutations in abnormal cells, points UCSF scientist

Aspirin is known to lower risk for some cancers, and a new study led by a UC San Francisco scientist points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.

19 Jun 2013

UCLA surgeons perform minimally invasive procedure to remove large polyps and keep colon intact

Millions of people each year have polyps successfully removed during colonoscopies. But when a suspicious polyp is bigger than a marble or in a hard-to-reach location, patients are referred for surgery to remove a portion of their colon - even if doctors aren't sure whether the polyp is cancerous or not.

18 Jun 2013

HPV antibodies may help identify individuals at increased risk of HPV-related oropharynx cancer

Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, which is a portion of the throat that contains the tonsils.

18 Jun 2013

Ibrutinib monotherapy shows efficacy in patients with MCL or DLBCL

Pharmacyclics, Inc. today announced the results of two separate Phase 2 studies suggesting that ibrutinib, an investigational oral Bruton's tyrosine kinase inhibitor, showed efficacy when used as a monotherapy in patients with relapsed/refractory mantle cell lymphoma or diffuse large B-cell lymphoma.

17 Jun 2013

Study shows how cancer cells interact with healthy cells to migrate around the body during metastasis

A mechanism that cells use to group together and move around the body - called 'chase and run' - has been described for the first time by scientists at UCL.

17 Jun 2013

Society of Interventional Radiology releases Updates in Interventional Radiology 2013

The Society of Interventional Radiology announces the release of "Updates in Interventional Radiology 2013," a concise reference of the current literature most relevant to the specialty.

13 Jun 2013

New collaboration to advance cancer immunotherapy research

The Cancer Research Institute, the Ludwig Institute for Cancer Research and Immune Design, a biotech company focused on immune-based therapies for cancer and other human diseases, today announced that they have signed a collaboration agreement to advance cancer immunotherapy research.

13 Jun 2013

TSRI scientists identify key triggers of cancer-blocking mechanism in cells

Scientists at The Scripps Research Institute have identified key triggers of an important cancer-blocking mechanism in cells.

12 Jun 2013

Education about malignant hyperthermia is important to medical professionals and community

Orlando Health, the Florida Society of PeriAnesthesia Nurses, and the Florida Society of Anesthesiologists took a moment to comment on a conference they are co-sponsoring with the Malignant Hyperthermia Association of the United States in Orlando on June 29.

11 Jun 2013

Current celiac disease screening method more cost-effective than universal screening, study finds

The current standard practice of screening adolescents who are either symptomatic or at high-risk for celiac disease proves to be more cost-effective than universal screening. Additionally, the strategy is successful in preventing bone loss and fractures in celiac patients, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

11 Jun 2013

Researchers find master regulator of EMT and metastasis

The predominant cause of death in cancer patients is metastasis, the formation of secondary tumors in other organs like the brain, liver, and lungs. Cancer cells detach from the original primary tumor and reach a single cell or group of cells in another organ. The cells of the body normally remain in place through adhering to an extracellular substance. However, cancer cells learn how to release themselves from these bonds and invade surrounding tissues, blood, and the lymphatic system.

11 Jun 2013

Researchers move closer to specific therapy to treat triple receptor-negative breast cancer

The search for a specific therapy to treat a particularly aggressive type of breast cancer has moved a step forward thanks to new research carried out by the University of Essex.

10 Jun 2013

Nation's leading experts join forces to accelerate effective treatments for brain tumors

The nation's leading brain tumor and biotech industry experts again joined forces Friday, June 7, in a bid to accelerate more effective treatments for brain tumors and promote funding for the latest emerging therapies, as the Weill Cornell Brain and Spine Center and Voices Against Brain Cancer hosted its second annual Brain Tumor Biotech Summit.

10 Jun 2013

New findings suggest development of pharmacological treatments for uterine leiomyomata

Uterine leiomyomata, or fibroids, are benign tumours that nevertheless affect the health of millions of women. They may cause, for instance, pain, bleeding and infertility. Fibroids are also the most common reason for a hysterectomy; for example, some 8,000 hysterectomies are made in Finland each year.

10 Jun 2013

Researchers solve long-standing mystery behind dormant disseminated breast tumor cells

The long-standing mystery behind dormant disseminated breast tumor cells and what activates them after years and even decades of latency may have been solved. Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature - the small blood vessels that transport blood within tissues - as a niche where dormant cancer cells reside. When these blood vessels begin to sprout, the new tips produce molecules that transform dormant cancer cells into metastatic tumors.

4 Jun 2013

Scientists pinpoint genetic traits of cells that give rise to gliomas

A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas - the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease.

4 Jun 2013

Malignant News and Research

TSRI scientists receive NIH grant to create new drug for chronic lymphocytic leukemia

Ibrutinib shows remarkable promise for treatment of mantle cell lymphoma

Results of ibrutinib Phase 2 study in patients with mantle cell lymphoma published in NEJM

Stress exposure may be associated with increased risk of aggressive breast cancer

Aspirin slows accumulation of DNA mutations in abnormal cells, points UCSF scientist

UCLA surgeons perform minimally invasive procedure to remove large polyps and keep colon intact

HPV antibodies may help identify individuals at increased risk of HPV-related oropharynx cancer

Ibrutinib monotherapy shows efficacy in patients with MCL or DLBCL

Study shows how cancer cells interact with healthy cells to migrate around the body during metastasis

Society of Interventional Radiology releases Updates in Interventional Radiology 2013

New collaboration to advance cancer immunotherapy research

TSRI scientists identify key triggers of cancer-blocking mechanism in cells

Education about malignant hyperthermia is important to medical professionals and community

Current celiac disease screening method more cost-effective than universal screening, study finds

Researchers find master regulator of EMT and metastasis

Researchers move closer to specific therapy to treat triple receptor-negative breast cancer

Nation's leading experts join forces to accelerate effective treatments for brain tumors

New findings suggest development of pharmacological treatments for uterine leiomyomata

Researchers solve long-standing mystery behind dormant disseminated breast tumor cells

Scientists pinpoint genetic traits of cells that give rise to gliomas

Industry Focus eBook - Cell biology (5th edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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