Preclinical News and Research

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Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Breast cancer, the second most common cancer in the United States, can result from a number of cellular misregulations, such as deficiencies in the DNA-repairing breast cancer gene, BRCA.

18 Dec 2020

Thermo Fisher announces construction of new cGMP plasmid DNA manufacturing facility

Thermo Fisher Scientific, the world leader in serving science, today announced the construction of a new cGMP plasmid DNA manufacturing facility in Carlsbad, Calif.

From Thermo Fisher Scientific Inc. 18 Dec 2020

Pig stem cells offer a new way to grow human organs for transplantation

In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly established stem cells from pigs, when injected into embryos, contributed to the development of only the organ of interest (the embryonic gut and liver), laying the groundwork for stem cell therapeutics and organ transplantation.

18 Dec 2020

Novel device may help restore total eye function

An international consortium of researchers is developing a new method to bring eyes back to life from deceased body donors for clinical research purposes.

18 Dec 2020

Hearing loss, high blood sugar linked to poor cognitive performance among older Latinos

Hearing loss and diabetes are major public health problems, with Latinos at higher risk than other demographic groups.

18 Dec 2020

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Positive results from additional analyses of PRIDE-HD and Open-HART trials with pridopidine published in a peer-reviewed journal, The Journal of Huntington's Disease.

17 Dec 2020

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

A pair of copper radionuclides that target the somatostatin receptor overexpressed in neuroendocrine tumors has proven successful in identifying tumors and improving survival.

16 Dec 2020

Researchers focus on preventing infections caused by carbapenemase-producing bacteria

In 2017, the World Health Organization published a list of pathogens for which new drugs are urgently needed.

16 Dec 2020

RedHill Biopharma announces promising preliminary results from opaganib study

TEL AVIV, Israel and RALEIGH, NC, December 15, 2020, RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced promising preliminary results from a preclinical study with opaganib.

15 Dec 2020

Novel MRI contrast agent shows strong potential as safer alternative to current products

Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image quality and allows radiologists who interpret MRI scans to pick up subtle anatomic details and abnormalities that might otherwise be missed.

15 Dec 2020

New class of targeted cancer drugs may prove effective in treating common types of leukemia

A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia.

15 Dec 2020

Eureka's InvisiMask human antibody nasal spray offers protection against SARS-CoV-2 in mice

Eureka Therapeutics, Inc. announced today successful preclinical results from its InvisiMask™ Human Antibody Nasal Spray in mice, which offers protection against SARS-CoV-2 S pseudotyped virus infection for up to 10 hours.

14 Dec 2020

Researchers examine whether regenerative patch for spina bifida defect can promote healing

Researchers are investigating whether a human umbilical cord patch placed on the spina bifida defect could improve healing after minimally invasive fetoscopic surgery in a clinical trial at The University of Texas Health Science Center at Houston.

14 Dec 2020

New combination therapy has potential to treat aggressive cancers with common mutations

Scientists have long known that therapies that target the cancer-driving MAPK pathway are only effective in a handful of cancers with specific mutations in a cancer gene called BRAF, and these cancers that initially respond to the therapy often end up developing resistance to the treatment, resulting in relapse for many patients.

14 Dec 2020

Vape flavorings can harm the heart

The appealing array of fruit and candy flavors that entice millions of young people take up vaping can harm their hearts, a preclinical study by University of South Florida Health (USF Health) researchers found.

11 Dec 2020

New analysis method could pave the way for important breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.

11 Dec 2020

Preclinical News and Research

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Thermo Fisher announces construction of new cGMP plasmid DNA manufacturing facility

Pig stem cells offer a new way to grow human organs for transplantation

Novel device may help restore total eye function

Hearing loss, high blood sugar linked to poor cognitive performance among older Latinos

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

Researchers focus on preventing infections caused by carbapenemase-producing bacteria

RedHill Biopharma announces promising preliminary results from opaganib study

Novel MRI contrast agent shows strong potential as safer alternative to current products

New class of targeted cancer drugs may prove effective in treating common types of leukemia

Eureka's InvisiMask human antibody nasal spray offers protection against SARS-CoV-2 in mice

Researchers examine whether regenerative patch for spina bifida defect can promote healing

New combination therapy has potential to treat aggressive cancers with common mutations

Vape flavorings can harm the heart

New analysis method could pave the way for important breakthroughs in immunotherapy

Osteoporosis drug also promotes infiltration of immune cells in breast tumors

MEDS433 hinders SARS-CoV-2 replication

Study: TMEM41B transmembrane protein is a critical factor for SARS-CoV-2 replication

UofL receives DoD funding to develop a nasal spray for preventing COVID-19

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