Proliferation News and Research

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Gut microbiome can play significant role in the body's response to gluten

Investigators interested in celiac disease, a chronic gastrointestinal disorder caused by an immunologic response to the ingestion of gluten, have wondered why only 2% to 5% of genetically susceptible individuals develop the disease.

8 Oct 2015

New report reveals more about how stem cells are affected by immediate surroundings

A Johns Hopkins University biologist has led a research team reporting progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.

8 Oct 2015

Myriad Genetics and Tufts Health Plan sign agreement to cover Prolaris® for members with localized prostate cancer

Myriad Genetics, Inc. (NASDAQ: MYGN) has announced that it has signed a three-year contract with Tufts Health Plan through which the plan will provide coverage of Prolaris® for members diagnosed with localized prostate cancer. Prolaris is the first and only biopsy test validated against prostate cancer specific mortality.

7 Oct 2015

Researchers describe unknown mechanism behind progeria

Progeria, a premature aging disease, is the research focus of Roland Foisner's team at the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna. Children suffering from progeria die at an average age of 14 to 15 years, often from heart attacks and strokes.

7 Oct 2015

Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

The whimsically named sonic hedgehog gene, best known for controlling embryonic development, also maintains the normal physiological state and repair process of an adult healthy lung, if damaged, according to new research from the Perelman School of Medicine at the University of Pennsylvania published online this week in Nature in advance of the print edition.

6 Oct 2015

Beta-catenin shows treatment target potential for TKI-resistant CML

Nuclear β-catenin could be a treatment target for patients whose chronic myeloid leukaemia is resistant to tyrosine kinase inhibitors independent of additional BCR–BL1 mutations, US researchers suggest.

1 Oct 2015

Oraya therapy is effective in maintaining vision with reduced injections for wet AMD patients

The results show that Oraya Therapy is effective in maintaining vision with reduced injections for patients at different stages of their disease—from chronic patients in discontinuous treatment to treatment-naive patients with new diagnosis—and following different treatment pathways.

1 Oct 2015

UH researcher investigates two new avenues for detection, treatment of prostate cancer

Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer-related deaths among men in the U.S. The challenge with prostate cancer is that the standard treatment methods in the advanced stage of the disease lose effectiveness after about one to two years, leading to recurrence and, ultimately, death. A University of Houston researcher and his team are working to change that.

30 Sep 2015

Aelan Cell Technologies, Gladstone Institutes partner to study stem cell rejuvenation

Aelan Cell Technologies today announced they have entered into an agreement with the Gladstone Institutes to further its studies on stem cell rejuvenation. This effort will be led by Meenakshi Gaur, Ph.D. of Aelan Cell Technologies and Kathryn Ivey, Ph.D. of the Gladstone Institutes.

30 Sep 2015

Immune checkpoint inhibitor increases survival in patients with advanced renal cell carcinoma

For the first time, an immune checkpoint inhibitor has been proven to increase survival among patients with advanced renal cell carcinoma (RCC), a patient population for whom treatment options are currently limited.

26 Sep 2015

Protein-coding gene identified as tumor suppressor for acute myeloid leukemia

A protein-coding gene called hnRNP K has been identified as a tumor suppressor for acute myeloid leukemia (AML), a finding that could be important for investigating how best to target treatment of a blood cancer striking mostly older individuals.

24 Sep 2015

Study demonstrates potential of FCPCs as new source for cartilage regeneration

The self-repair of injured cartilage is difficult for several reasons, foremost of which is the lack of blood supply to the tissue. Therapeutic efforts aimed at cartilage repair are often not optimal. Surgical repair techniques often lead to the formation of fibrocartilage, which is weaker and less durable. Although cell transplantation aimed at cartilage repair has been carried out using mesenchymal stem cells (MSCs), varying outcomes have resulted, despite the propensity of MSCs to proliferate and differentiate.

23 Sep 2015

Discovery may lead to potential treatment strategies for type 2 diabetes

Insensitivity to insulin, also called insulin resistance, is associated with type 2 diabetes and affects several cell types and organs in the body. Now, scientists from Sweden's Karolinska Institutet have discovered a mechanism that explains how insulin-producing cells can be insulin resistant and insulin sensitive at the same time.

18 Sep 2015

Researchers identify triple mechanism that prevents onset of chromosomal instability

Universitat Autònoma de Barcelona researchers have identified for the first time the triple mechanism that stops chromosome separation in response to situations that compromise the integrity of the genetic information. The loss of this response capacity is characteristic of cancerous cells.

18 Sep 2015

Specific biomarker predicts which HER2-negative breast cancer patients respond to targeted therapy

A multicenter team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment.

18 Sep 2015

Roflumilast drug could inhibit growth of brain tumor in children

Current drugs may stop working against the most common type of brain tumor in children, medulloblastoma, but the tumor could be targeted in a new way, according to Stanford University scientists.

15 Sep 2015

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy - embedding stem cells into porous, transplantable hydrogels - that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation.

15 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

Researchers identify new epigenetic markers for colorectal cancer

Researchers at Nanjing University, China, found new epigenetic markers for colorectal cancer which may offer a new approach for treatment.

14 Sep 2015

Researchers now have a way to study special proteins linked to different diseases, cancer

Researchers from Northwestern University and Yale University have developed a user-friendly technology to help scientists understand how proteins work and fix them when they are broken. Such knowledge could pave the way for new drugs for a myriad of diseases, including cancer.

11 Sep 2015

Proliferation News and Research

Gut microbiome can play significant role in the body's response to gluten

New report reveals more about how stem cells are affected by immediate surroundings

Myriad Genetics and Tufts Health Plan sign agreement to cover Prolaris® for members with localized prostate cancer

Researchers describe unknown mechanism behind progeria

Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

Beta-catenin shows treatment target potential for TKI-resistant CML

Oraya therapy is effective in maintaining vision with reduced injections for wet AMD patients

UH researcher investigates two new avenues for detection, treatment of prostate cancer

Aelan Cell Technologies, Gladstone Institutes partner to study stem cell rejuvenation

Immune checkpoint inhibitor increases survival in patients with advanced renal cell carcinoma

Protein-coding gene identified as tumor suppressor for acute myeloid leukemia

Study demonstrates potential of FCPCs as new source for cartilage regeneration

Discovery may lead to potential treatment strategies for type 2 diabetes

Researchers identify triple mechanism that prevents onset of chromosomal instability

Specific biomarker predicts which HER2-negative breast cancer patients respond to targeted therapy

Roflumilast drug could inhibit growth of brain tumor in children

New strategy improves bone repair by boosting survival rate of transplanted stem cells

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Researchers identify new epigenetic markers for colorectal cancer

Researchers now have a way to study special proteins linked to different diseases, cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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