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Researchers explore potential of neural stem cells to repair brain damage

Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new Johns Hopkins research in mice suggests that neural stem cells, the body’s source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like state to reproduce and generate new cells able to migrate, replace injured cells and potentially restore lost function.

13 Aug 2013

Learning "grammar" helps determine whether gene gets switched on or not

Researchers have probed deep into the cell's genome, beyond the basic genetic code, to begin learning the "grammar" that helps determine whether or not a gene gets switched on to make the protein it encodes.

13 Aug 2013

URMC launches new device to improve treatment of heart disease in Asian population

Cardiologists at the University of Rochester Medical Center are launching a new study in an effort to improve the treatment of a very common form of heart disease in the Asian population.

12 Aug 2013

Carbon ion radiotherapy controls cancer growth, prolongs survival in patients with spinal tumors

A new analysis has found that a type of radiation therapy called carbon ion radiotherapy can control cancer growth and prolong survival in patients with spinal tumors. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that the treatment is a promising alternative for patients whose spinal tumors cannot be surgically removed.

12 Aug 2013

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

Researchers at The Pennsylvania State University College of Medicine, led by Dr. Ian S. Zagon, have discovered that a novel biological pathway, the OGF-OGFr axis, can be modulated in human triple-negative breast cancer cells to inhibit proliferation. According to BreastCancer.org 1 in 8 women in the U.S. will develop invasive breast cancer and more than 39,000 deaths occur annually.

12 Aug 2013

Study investigates issues faced by prisoners with mental health problems after release

Offenders, and especially prisoners, have a high prevalence of mental health problems. Rates for various mental health conditions range from 50 to 90 per cent. Prisoners released from prison with mental health problems face difficulty with family relationships, employment, long-term illness, self-harm, depression and re-offending.

12 Aug 2013

Study of childhood epilepsies links two new genes to severe forms of disease

A genetic study of childhood epilepsies has linked two new genes to severe forms of disease and provides a novel strategy for identifying therapy targets. This study used a cutting-edge genetic technique, called exome sequencing, to search for new mutations that are not inherited.

12 Aug 2013

Gene combination therapy repairs and prevents future damage of muscles caused by DMD

New research on two promising gene therapies suggests that combining them into one treatment not only repairs muscle damage caused by Duchenne muscular dystrophy, but also prevents future injury from the muscle-wasting disease.

12 Aug 2013

Researchers identify biomarkers of TB that may help in new treatments

Researchers at the University of Southampton have identified new markers of tuberculosis (TB) that may help in the development of new diagnostic tests and treatments.

12 Aug 2013

AliveCor Heart Monitor for iPhone can detect heart rhythm problems, prevent strokes

A special iPhone case and app can be used to quickly and cheaply detect heart rhythm problems and prevent strokes, according to University of Sydney research presented at the Australia and New Zealand Cardiac Society conference today on the Gold Coast.

9 Aug 2013

Celgene's pomalidomide gets approval in UK for multiple myeloma

Celgene confirmed today that Pomalidomide Celgene▼ (pomalidomide), a new oral blood cancer therapy, has been granted Marketing Authorisation by the European Medicines Agency and is now available in the UK and Ireland.

9 Aug 2013

Research suggests blocking DNA repair complex helps fight therapy-resistant leukemia

New research posted online by the Nature journal Leukemia suggests blocking part of a DNA repair complex that helps some types of leukemia resist treatment can increase the effectiveness of chemotherapy and enhance survival.

9 Aug 2013

High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

High mobility group A genes are highly expressed in all aggressive cancers studied to date. These genes encode the high mobility group A (HMGA) proteins. In other words, these genes provide the genetic “code” necessary to produce HMGA proteins.

8 Aug 2013

One-third of patients with heart pumps develop infection at abdominal power connection site

Cardiac surgeons and cardiologists at the University of Maryland Heart Center are part of a multi-center clinical trial evaluating the efficacy of powering heart pumps through a skull-based connector behind the ear. Typically, these devices for patients with severe heart failure are energized through an electrical cord connected at an abdominal site, where potentially deadly infections can develop.

8 Aug 2013

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

Janssen-Cilag International NV announced today that the European Commission has approved the use of VELCADE (bortezomib) as induction therapy (a first therapeutic option) in combination with dexamethasone or thalidomide and dexamethasone. This licence extension will apply to adult patients with previously-untreated multiple myeloma who are eligible for high-dose chemotherapy with haematological stem cell transplantation.

8 Aug 2013

State highlights: Wis. AG says hospitals can't deny admitting privileges to abortion docs

Plans by three Catholic hospital systems in Wisconsin to deny admitting privileges to doctors who perform abortions would "be in active violation of federal law," state Attorney General J. B. Van Hollen's Department of Justice said in a court filing last week. Federal law "provides that hospitals accepting federal funds may not discriminate against a physician because that physician has participated in or refused to participate in abortions," the state Justice Department said in its filing in federal court (Ahmed, 8/7).

8 Aug 2013

Standardizing care for penile cancer

Penile cancer is rare, with an average of 1,200 new cases per year in the United States, but it can be debilitating and lethal. Without evidenced-based treatment approaches, outcomes have varied widely. Philippe E. Spiess, M.D., an associate member in the Department of Genitourinary Oncology at Moffitt Cancer Center, presented new National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology to standardize care for penile cancer in an article that appeared in the July issue of the Journal of the National Comprehensive Cancer Network.

8 Aug 2013

AmpliPhi releases data on phage therapy for treatment of lung infections in Cystic Fibrosis patients

AmpliPhi BioSciences Corp. (OTC: APHB) ("AmpliPhi"), the leader in the development of bacteriophage-based antibacterial therapies to treat drug resistant bacterial infections, yesterday presented data relating to the use of bacteriophages in the treatment of Pseudomonas aeruginosa (P. aeruginosa) at the 20th Biennial Evergreen International Phage Meeting held in Olympia, Washington, USA. P. aeruginosa is the major cause of lung infections in cystic fibrosis (CF) patients.

8 Aug 2013

UAH invents smart pill bottle that notifies you to take your medications

Patented at The University of Alabama in Huntsville, (UAH), a smart pill bottle that notifies you to take your medications or reminds you if you missed a dose could be en route to medicine cabinets as soon as 2015.

8 Aug 2013

Cognitive decline with age is natural part of life, OSU researchers find

If you forget where you put your car keys and you can't seem to remember things as well as you used to, the problem may well be with the GluN2B subunits in your NMDA receptors.

8 Aug 2013

Therapy News and Research

Researchers explore potential of neural stem cells to repair brain damage

Learning "grammar" helps determine whether gene gets switched on or not

URMC launches new device to improve treatment of heart disease in Asian population

Carbon ion radiotherapy controls cancer growth, prolongs survival in patients with spinal tumors

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

Study investigates issues faced by prisoners with mental health problems after release

Study of childhood epilepsies links two new genes to severe forms of disease

Gene combination therapy repairs and prevents future damage of muscles caused by DMD

Researchers identify biomarkers of TB that may help in new treatments

AliveCor Heart Monitor for iPhone can detect heart rhythm problems, prevent strokes

Celgene's pomalidomide gets approval in UK for multiple myeloma

Research suggests blocking DNA repair complex helps fight therapy-resistant leukemia

High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

One-third of patients with heart pumps develop infection at abdominal power connection site

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

State highlights: Wis. AG says hospitals can't deny admitting privileges to abortion docs

Standardizing care for penile cancer

AmpliPhi releases data on phage therapy for treatment of lung infections in Cystic Fibrosis patients

UAH invents smart pill bottle that notifies you to take your medications

Cognitive decline with age is natural part of life, OSU researchers find

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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