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University of Leicester-led study finds way to reverse symptoms of Parkinson’s and Alzheimer’s

A five-year study by an international team led from the University of Leicester has found a way of ‘reversing’ symptoms of neurodegenerative diseases such as Parkinson’s and Alzheimer’s – using fruit flies as test subjects.

26 Apr 2016

Researchers reveal how bile component taurine attracts Vibrio cholera

A group of researchers from Osaka University, Hosei University, and Nagoya University have revealed the molecular mechanism that Vibrio cholerae, the etiological agent of cholera, is attracted by bile. This group has also successfully detected the ligand binding to the bacteria chemoreceptor in vivo for the first time. These results may significantly advance research on mechanism and control of V. cholerae.

26 Apr 2016

MALT1 inhibitors may be useful for treating psoriasis patients with CARD14 mutations

Psoriasis is a long-lasting autoimmune disease that is characterized by patches of abnormal and inflamed skin. It is generally thought to have a genetic origin, which can be further triggered by environmental factors. People with specific mutations in the CARD14 gene have a high probability of developing psoriasis.

25 Apr 2016

Decrease in serum zinc levels may cause inflammation among HIV positive individuals

In a new study, University of Massachusetts Amherst researchers Krishna Poudel and colleagues report that zinc deficiency may contribute to chronic inflammation among HIV-positive individuals. Theirs is believed to be the first investigation to explore the association between serum zinc levels and inflammation among people with human immunodeficiency virus (HIV) infection, while taking their anti-retroviral therapy (ART) into account.

25 Apr 2016

Newly identified molecular pathway could lead to new treatments for reflux, incontinence disorders

Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system.

25 Apr 2016

Study on HDAC enzymes could lead to development of better drugs for treatment of cancer, Alzheimer’s

New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer’s, according to research led by the University of Leicester.

25 Apr 2016

Scientists derive first molecular model of critical transporter at blood-brain barrier

Scientists from Duke-NUS Medical School have derived a structural model of a transporter at the blood-brain barrier called Mfsd2a. This is the first molecular model of this critical transporter, and could prove important for the development of therapeutic agents that need to be delivered to the brain --- across the blood-brain barrier. In future, this could help treat neurological disorders such as glioblastoma.

25 Apr 2016

Researchers develop real-time single molecule electronic DNA sequencing platform

Researchers from Columbia University, with colleagues at Genia Technologies, Harvard University and the National Institute of Standards and Technology report achieving real-time single molecule electronic DNA sequencing at single-base resolution using a protein nanopore array.

25 Apr 2016

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature.

25 Apr 2016

NASA's research program uses omics to look more closely at individual health

NASA's Human Research Program is releasing the first half of a video series entitled Omics: Exploring Space Through You to highlight its Twins Study, in conjunction with its National DNA Day Reddit Ask Me Anything event at 10 a.m. CDT/11 a.m. EDT, Monday, April 25, 2016. The series explores space through you by using omics to look more closely at individual health.

22 Apr 2016

Novel function of PLK1 gene in prostate cancer metastasis

Researchers at VCU Massey Cancer Center have uncovered a novel function of the gene PLK1 (polo-like kinase 1) that helps prostate cancer cells metastasize (spread) to other parts of the body. This mechanism highlights new potential targets for cancer therapies and challenges the previous understanding of PLK1's role in cancer growth and progression.

22 Apr 2016

Unique mouse model could help study genetic origins and potential treatments for ALS

University of Florida Health researchers have developed a unique mouse model that will allow researchers around the world to better study the genetic origins and potential treatments for a neurodegenerative brain disease that causes amyotrophic lateral sclerosis, often referred to as ALS or Lou Gehrig's disease, and frontotemporal dementia.

22 Apr 2016

Rab inhibition may be a promising antimyeloma strategy

Roswell Park Cancer Institute researchers are investigating agents that target and disrupt the trafficking of monoclonal antibodies in multiple myeloma, a cancer of the bone marrow. The results will be presented at the American Association for Cancer Research Annual Meeting 2016, to be held April 16-20 in New Orleans.

22 Apr 2016

Disorders in PIGG gene can cause intellectual disability with seizures and hypotonia

A research group led by Osaka University and collaborative institutions discovered that disorders in the same gene PIGG are the cause for intellectual disability with seizures and hypotonia. PIGG is one of the enzymes active in the GPI anchor glycolipid synthesis and the current study revealed its significance in the development of the cerebral nervous system.

22 Apr 2016

CUMC researchers identify new neurodevelopmental syndrome

A multicenter research team led by Columbia University Medical Center has discovered a new neurodevelopmental syndrome and the genetic mutations that cause it. The discovery is an important step toward creating targeted therapies for individuals with this syndrome, which causes severe developmental delays, abnormal muscle tone, seizures, and eye complications.

22 Apr 2016

Microtubules affect mechanics of beating heart, study finds

On top of the meaning and mystery that humans heap on the heart, it is first and foremost, a muscle. And one that beats about once a second for a person's entire life, with no rest. Given its vital importance, it's ironic researchers have only recently made direct observations of its subcellular parts in motion.

22 Apr 2016

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

Multiple myeloma (MM) is a hematological cancer that frequently acquires resistance to chemotherapeutic drugs. Additionally, many patients experience disease relapse, but these patients are difficult to treat as the cancer is often resistant to the previous treatment regimen.

22 Apr 2016

FAU's clinical trial to evaluate efficacy of RVT-101 tablet for Lewy body dementia

Florida Atlantic University's Charles E. Schmidt College of Medicine is spearheading the South Florida site for the first U.S. clinical trial for Lewy body dementia (LBD), the second-most common dementia after Alzheimer's disease. The HEADWAY-DLB is a phase 2b multi-center, double-blind, placebo-controlled study to evaluate an investigational medicine, RVT-101, for dementia with Lewy bodies.

22 Apr 2016

Subtle changes in protein-coding gene may cause different genetic disorders

It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell "commitment."

22 Apr 2016

Researchers determine 3-D structure of RlmN protein from bacteria

The structure of a bacterial RNA-binding protein has been determined in the act of modifying a molecule of RNA -- an achievement that provides researchers with a unique view of the protein's function in action and could lead to clues that would help in the fight against the development of antibiotic-resistant infections.

22 Apr 2016

G Protein News and Research

University of Leicester-led study finds way to reverse symptoms of Parkinson’s and Alzheimer’s

Researchers reveal how bile component taurine attracts Vibrio cholera

MALT1 inhibitors may be useful for treating psoriasis patients with CARD14 mutations

Decrease in serum zinc levels may cause inflammation among HIV positive individuals

Newly identified molecular pathway could lead to new treatments for reflux, incontinence disorders

Study on HDAC enzymes could lead to development of better drugs for treatment of cancer, Alzheimer’s

Scientists derive first molecular model of critical transporter at blood-brain barrier

Researchers develop real-time single molecule electronic DNA sequencing platform

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

NASA's research program uses omics to look more closely at individual health

Novel function of PLK1 gene in prostate cancer metastasis

Unique mouse model could help study genetic origins and potential treatments for ALS

Rab inhibition may be a promising antimyeloma strategy

Disorders in PIGG gene can cause intellectual disability with seizures and hypotonia

CUMC researchers identify new neurodevelopmental syndrome

Microtubules affect mechanics of beating heart, study finds

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

FAU's clinical trial to evaluate efficacy of RVT-101 tablet for Lewy body dementia

Subtle changes in protein-coding gene may cause different genetic disorders

Researchers determine 3-D structure of RlmN protein from bacteria

Industry Focus eBook - Cell biology (5th edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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