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Muscle loss from GLP-1 drugs could undermine long-term health

Popular GLP-1 drugs help many people drop tremendous amounts of weight, but the drugs fail to provide a key improvement in heart and lung function essential for long-term good health, University of Virginia experts warn in a new paper.

21 Jul 2025

Gene editing in the brain offers hope for ultra-rare neurological disease

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

21 Jul 2025

Combination of two cancer drugs could treat the most common form of dementia

A study comparing the gene expression signature of Alzheimer's disease with those elicited by 1,300 approved drugs found a combination of two cancer medications that could treat the most common form of dementia.

21 Jul 2025

Novel polysaccharide from Albizzia julibrissin shows promise against pancreatic cancer

Albizzia julibrissin is a widely distributed plant in China. Its dried stem bark has been used in traditional oriental medicine to treat insomnia, diuresis, sthenia, ascaricide, and confusion.

21 Jul 2025

Gecko-inspired nanoparticles deliver targeted chemotherapy to tumors

As far back as the 4th Century B.C., Aristotle marveled at the nimble gecko's ability to "run up and down a tree in any way, even with the head downwards."

21 Jul 2025

Fluorescent bacteria enable real-time tumor visualization during surgery

Accurate removal of tumors is the most critical aspect of cancer surgery, yet it remains a significant challenge in clinical practice.

21 Jul 2025

Microbial signals rewire immunity in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with particularly high prevalence in East Asia.

21 Jul 2025

Can probiotics help you sleep better?

A new meta-analysis shows that probiotic supplements can modestly improve sleep quality and reduce depressive symptoms in people with insomnia, with no significant safety concerns. However, effects on total sleep time and sleep efficiency remain uncertain, and evidence strength varies across outcomes.

20 Jul 2025

Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy

In a mouse model of acute ischemic stroke, researchers showed that inhibiting the aggregation of GAPDH, either genetically or with a novel peptide, significantly reduced brain damage and improved neurological function. The findings highlight GAPDH aggregation as a promising therapeutic target for stroke intervention.

20 Jul 2025

AI turns old diabetes drug Halicin into a potent weapon against superbugs

Researchers found that Halicin, an AI-identified drug, effectively inhibited most multidrug-resistant bacteria except Pseudomonas aeruginosa. The study highlights Halicin’s broad-spectrum antibacterial potential and the transformative role of artificial intelligence in antibiotic discovery.

20 Jul 2025

Microbial therapy uses modified bacteria to target oxalate in the gut

Engineered gut bacteria designed to treat kidney stones successfully colonized the gut microbiome and reduced oxalate levels in animal models and early clinical trials in humans, researchers report.

18 Jul 2025

Developing AI-driven stem cell therapies to fight ovarian aging

Ovarian aging, characterized by diminishing egg reserves and quality, affects millions of women worldwide, often leading to infertility.

18 Jul 2025

Emerging therapies reshape the future of AMD treatment

Age-related macular degeneration (AMD) remains a leading cause of vision loss globally, with significant advancements in treatment options for both dry and wet AMD.

18 Jul 2025

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Cuproptosis represents a novel mechanism of cell death characterized by intracellular copper ion accumulation.

18 Jul 2025

New mRNA vaccine strategy awakens immune system to fight cancer

An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to "wake up" the immune system against cancer.

18 Jul 2025

Research highlights guselkumab's impact on Crohn's endoscopic healing

In a major advance for patients with Crohn's disease, a new study led by researchers at Mount Sinai Health System found that guselkumab, a medication with a mechanism of action that is new to inflammatory bowel disease (IBD) treatment, outperformed an established standard of care in promoting intestinal healing and symptom relief.

18 Jul 2025

Study identifies SDR42E1's role in vitamin D pathway

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health: it regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.

18 Jul 2025

Chronic venous insufficiency linked to increased cardiovascular disease and mortality risk

In light of reports from the White House that President Donald J. Trump has been diagnosed with Chronic Venous Insufficiency (CVI), the American Heart Association is sharing important information on the condition and its association with cardiovascular risk factors, disease and increased risk of death.

18 Jul 2025

Specially engineered antibody delivers RNA therapy to treatment-resistant tumors

A specially engineered antibody capable of delivering RNA therapies to hard-to-reach, treatment-resistant tumors significantly shrank tumor size and improved survival in animal models, according to a study published July 16 in Science Translational Medicine.

17 Jul 2025

Study casts doubt on a widely used shortcut in rectal cancer drug trials

A new study by a Tulane University researcher casts doubt on a widely used shortcut in rectal cancer drug trials, raising concerns that some treatments may be fast-tracked for approval without evidence they help patients live longer.

17 Jul 2025