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Findings provide basis for reinvigoration of research efforts in breast cancer prevention

Genetic variations, known as single nucleotide polymorphisms, in or near the genes ZNF423 and CTSO were associated with breast cancer risk among women who underwent prevention therapy with tamoxifen and raloxifene, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

14 Jun 2013

Study provides new insight into how pyrazinamide works

Pyrazinamide (PZA)-a frontline tuberculosis drug-kills dormant persister bacteria and plays a critical role in shortening TB therapy. PZA is used for treating both drug susceptible and multi-drug resistant TB but resistance to PZA occurs frequently and can compromise treatment.

14 Jun 2013

Penn Medicine researchers identify key molecular player in recurrent breast cancer

According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence - the reappearance of the disease following treatment.

14 Jun 2013

Mount Sinai researchers produce cells that resemble hematopoietic stem cells

By transferring four genes into mouse fibroblast cells, researchers at the Icahn School of Medicine at Mount Sinai have produced cells that resemble hematopoietic stem cells, which produce millions of new blood cells in the human body every day.

14 Jun 2013

New study tests vestibular prosthesis to help restore balance for people with Meniere's disease

Many disorders of the inner hear which affect both hearing and balance can be hugely debilitating and are currently largely incurable. Cochlear implants have been used for many years to replace lost hearing resulting from inner ear damage.

14 Jun 2013

NACC recommendations address established pain therapies and preview potential future advances

Recommendations of the Neuromodulation Appropriateness Consensus Committee (NACC), announced at the 11th World Congress of the International Neuromodulation Society (INS), address established therapies and preview emerging and potential future advances.

13 Jun 2013

Study: Tocilizumab is effective in children with juvenile idiopathic arthritis

A new study presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism shows that tocilizumab is efficacious and leads to a sustained clinically meaningful improvement in children with polyarticular Juvenile Idiopathic Arthritis (pcJIA).

13 Jun 2013

Ustekinumab doses improve signs and symptoms of PsA with favourable safety profiles

New PSUMMIT 2 data first presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, further demonstrate the efficacy of ustekinumab in Psoriatic Arthritis (PsA).

13 Jun 2013

NBMC signs contract for Unibased's ForSite2020 solutions

Unibased Systems Architecture, Inc. announced today that North Bend Medical Center, Inc., located in Coos Bay, OR, has signed an agreement for its market-leading surgery management solution, ForSite2020 periOperative Resource Management System, aimed at improving workflow and productivity as well as providing efficient resource management to reduce costs and effectively manage inventory.

13 Jun 2013

Combination of Pressure Right and antiemetic drug therapy can reduce PONV with no adverse effects

From a clinical-based perspective, postoperative nausea and vomiting (PONV) can be characterized as an unmet global phenomenon in which anesthesia practitioners and PACU nurses worldwide are seeking more efficient clinical strategies for preventing PONV.

13 Jun 2013

Apremilast continues to demonstrate meaningful clinical responses in patients with psoriatic arthritis

New data presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism show that apremilast administered to patients with psoriatic arthritis continues to demonstrate meaningful clinical responses beyond 24 weeks.

13 Jun 2013

Study demonstrates efficacy of ARASHI method at evaluating radiographic joint damage in RA

A new study presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrates the efficacy of the ARASHI method at evaluating radiographic (X-ray) joint damage in RA.

13 Jun 2013

TSRI scientists find emotion-related brain region plays major role in sustaining cocaine addiction

Scientists at The Scripps Research Institute (TSRI) have found evidence that an emotion-related brain region called the central amygdala—whose activity promotes feelings of malaise and unhappiness—plays a major role in sustaining cocaine addiction.

13 Jun 2013

Using Swiss ball improves walking performance and muscle strength in AS patients

A new study presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrates that progressive muscle strengthening using a Swiss ball is effective in improving muscle strength and walking performance in patients with Ankylosing Spondylitis (AS).

13 Jun 2013

Society of Interventional Radiology releases Updates in Interventional Radiology 2013

The Society of Interventional Radiology announces the release of "Updates in Interventional Radiology 2013," a concise reference of the current literature most relevant to the specialty.

13 Jun 2013

PTSD patients with Met-66 allele of BDNF show poorer response to exposure therapy

There is growing evidence that a gene variant that reduces the plasticity of the nervous system also modulates responses to treatments for mood and anxiety disorders. In this case, patients with posttraumatic stress disorder, or PTSD, with a less functional variant of the gene coding for brain-derived neurotrophic factor, responded less well to exposure therapy.

13 Jun 2013

WHO issues interim policy guidance on inclusion of bedaquiline to treat adults with MDR-TB

WHO estimates that up to half a million new cases of multidrug-resistant tuberculosis occur worldwide, each year. Current treatment regimens for MDR-TB present many challenges: treatment lasts 20 months or more, requiring daily administration of drugs that are more toxic, less effective, and far more expensive than those used to treat drug-susceptible TB.

13 Jun 2013

Constella® (linaclotide), for the symptomatic treatment of Irritable Bowel Syndrome with Constipation (IBS-C), is now available in Germany, UK and Nordic countries

Almirall, S.A. (ALM:MC) and Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) announced the launch of Constella® (linaclotide 290mcg capsules once daily), the first approved prescription therapy in a new class of treatments for adults suffering from moderate to severe IBS-C,(1) in Europe. Constella® is now available in Germany, the UK and Nordic countries and is expected to be launched in several other European countries in 2013.

13 Jun 2013

Investigational all-oral interferon-free combination from Boehringer Ingelheim achieves 95% viral cure rates in genotype-1b hepatitis C patients

New data from Boehringer Ingelheim’s interferon-free SOUND-C3 study were presented during the APASL Liver Week in Singapore. The Phase IIb study investigated the efficacy and safety of faldaprevir+ and deleobuvir+ (BI 207127) plus ribavirin in treatment-naïve patients with genotype-1b (GT-1b) hepatitis C virus (HCV),1 one of the most common types of HCV globally.2

13 Jun 2013

One-third of RA patients discontinue therapy within the first year of treatment

Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that up to one-third of rheumatoid arthritis patients discontinue or change therapy within the first year of treatment.

13 Jun 2013

Therapy News and Research

Findings provide basis for reinvigoration of research efforts in breast cancer prevention

Study provides new insight into how pyrazinamide works

Penn Medicine researchers identify key molecular player in recurrent breast cancer

Mount Sinai researchers produce cells that resemble hematopoietic stem cells

New study tests vestibular prosthesis to help restore balance for people with Meniere's disease

NACC recommendations address established pain therapies and preview potential future advances

Study: Tocilizumab is effective in children with juvenile idiopathic arthritis

Ustekinumab doses improve signs and symptoms of PsA with favourable safety profiles

NBMC signs contract for Unibased's ForSite2020 solutions

Combination of Pressure Right and antiemetic drug therapy can reduce PONV with no adverse effects

Apremilast continues to demonstrate meaningful clinical responses in patients with psoriatic arthritis

Study demonstrates efficacy of ARASHI method at evaluating radiographic joint damage in RA

TSRI scientists find emotion-related brain region plays major role in sustaining cocaine addiction

Using Swiss ball improves walking performance and muscle strength in AS patients

Society of Interventional Radiology releases Updates in Interventional Radiology 2013

PTSD patients with Met-66 allele of BDNF show poorer response to exposure therapy

WHO issues interim policy guidance on inclusion of bedaquiline to treat adults with MDR-TB

Constella® (linaclotide), for the symptomatic treatment of Irritable Bowel Syndrome with Constipation (IBS-C), is now available in Germany, UK and Nordic countries

Investigational all-oral interferon-free combination from Boehringer Ingelheim achieves 95% viral cure rates in genotype-1b hepatitis C patients

One-third of RA patients discontinue therapy within the first year of treatment

Industry Focus eBook - Cell biology (5th edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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