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Researchers discover mutation that amplifies capabilities of tumor-suppressor protein

Cancer researchers have long hailed p53, a tumor-suppressor protein, for its ability to keep unruly cells from forming tumors. But for such a highly studied protein, p53 has hidden its tactics well.

9 Oct 2017

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

9 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

University of Akron researcher awarded NSF grant to study bone remodeling

Osteoporosis is a disease categorized by brittle bones and increased risk of fracture. Individuals with osteoporosis, and diseases like it, have access to a number of treatments but no permanent solution.

9 Oct 2017

Whitehead Institute scientists identify brain/body connection in genomic region linked to autism

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes--fam57ba and doc2a--in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

9 Oct 2017

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

An international team led by scientists at the National Institutes of Health is the first to discover a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein cross-link.

6 Oct 2017

New topical treatment to combat skin cancer yields promising results in preliminary study

Researchers at the University of São Paulo (USP), in Brazil, are testing a technique in mice that combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy to treat skin cancer.

6 Oct 2017

Penn study explains how acute viral infections can linger

Infections caused by viruses, such as respiratory syncytial virus, or RSV, measles, parainfluenza, and Ebola, are typically considered acute. These viruses cause disease quickly and live within a host for a limited time. But in some cases, the effects of the infection, and presence of the virus itself, can persist.

6 Oct 2017

New microcapsules represent promising vectors for application of genome-editing tools

Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient in genome-editing when applying CRISPR-Cas9 system.

6 Oct 2017

Genetic signature within prostate cancer cells can predict metastatic tumors

Many prostate cancers, which generally are diagnosed in older men, are "indolent," slow-growing tumors that aren't destined to be fatal. But some tumors are prone to becoming aggressive and spreading beyond the prostate, making them difficult to treat and life-threatening.

6 Oct 2017

Markey's cancer researcher wins NIH's New Innovator Award

University of Kentucky Markey Cancer Center Researcher Jessica Blackburn has earned a prestigious National Institutes of Health's New Innovator Award, a grant totaling $1.5 million over five years to fund pediatric cancer research.

6 Oct 2017

Researchers find surprising differences in first-ever whole-brain map of inhibitory neurons

Researchers at Penn State College of Medicine have collaborated on the first-ever quantitative whole-brain map of inhibitory neurons in the mouse brain. These brain cells play a crucial role in regulating response to stimuli and have been widely implicated in many psychiatric conditions.

6 Oct 2017

UC Berkeley researchers to develop new ultra-high-resolution MRI brain scanner

Functional magnetic resonance imaging, or fMRI, has transformed our view of the brain, allowing researchers to pinpoint areas associated with everything from depression and dementia to playing chess and engaging in sex.

6 Oct 2017

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery.

6 Oct 2017

UC Davis professor wins NIH award to develop ‘smart’ immune cells for cancer therapies

Assistant Professor Sean Collins, Department of Microbiology and Molecular Genetics in the UC Davis College of Biological Sciences, has received a $1.5 million award from the National Institutes of Health to advance the development of "smart" immune cells for therapies to treat cancer and other diseases.

6 Oct 2017

Research explains why mTOR inhibitors show limited ability to kill cancer

Anti-cancer drugs called mTOR inhibitors slow the growth of cancer cells but show limited ability to cause cancer cell death. New studies explain why.

6 Oct 2017

Study to determine lowest dose of chemotherapy needed for babies with SCID

Michael Pulsipher, MD, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, along with co-principal investigator, Sung-Yun Pai, MD, of Boston Children's Hospital, has been awarded nearly $9 million from the National Institute of Allergy and Infectious Diseases of the NIH to study a new treatment approach for babies born with severe combined immunodeficiency (SCID) which prevents the immune system from functioning normally.

6 Oct 2017

B Cell News and Research

Researchers discover mutation that amplifies capabilities of tumor-suppressor protein

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Study provides insights into non-oncogenic addictions of tumors

University of Akron researcher awarded NSF grant to study bone remodeling

Whitehead Institute scientists identify brain/body connection in genomic region linked to autism

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

New topical treatment to combat skin cancer yields promising results in preliminary study

Penn study explains how acute viral infections can linger

New microcapsules represent promising vectors for application of genome-editing tools

Genetic signature within prostate cancer cells can predict metastatic tumors

Markey's cancer researcher wins NIH's New Innovator Award

Researchers find surprising differences in first-ever whole-brain map of inhibitory neurons

UC Berkeley researchers to develop new ultra-high-resolution MRI brain scanner

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

UC Davis professor wins NIH award to develop ‘smart’ immune cells for cancer therapies

Research explains why mTOR inhibitors show limited ability to kill cancer

Study to determine lowest dose of chemotherapy needed for babies with SCID

CRI scientists challenge oldest concept in tumor metabolism

CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line

New cell therapy restores movement in people with paralyzing spinal cord injuries

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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