Antigen News and Research

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New method shortens the timeline to generate mice for vaccine research

To develop vaccines and investigate human immune responses, scientists rely on a variety of animal models, including mice that can produce human antibodies through genetically engineered B cell receptors, which are specialized antibodies bound to the B cell membrane.

14 Dec 2020

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

The focus is increasingly moving towards vaccine roll-out as the world faces the real possibility of the second year of social and economic restrictions.

14 Dec 2020

Less sensitive rapid tests may miss asymptomatic/presymptomatic SARS-CoV-2 infection

The rapid transmissibility of SARS-CoV-2 has posed a significant challenge to COVID-19 containment measures.

14 Dec 2020

Epitope “megapools” could help determine role T cell immunity plays in COVID-19

Researchers in the United States and Australia have conducted a comprehensive analysis of the epitope recognition patterns associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans.

14 Dec 2020

Recovered COVID-19 patients exhibit persistent cellular immunity

Researchers at The Rockefeller University in New York have conducted a study showing that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – triggers persistent T cell responses that last for at least six months.

14 Dec 2020

Study shows how STAT5 optimizes function of CD4+ T cells to drive antitumor immunity

Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's blood and subjected to genetic engineering to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) that is designed to enable T cells to recognize and destroy cancer cells.

14 Dec 2020

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

According to the results of research led by the Complutense University of Madrid (UCM), one the various strategies deployed by the Leishmania parasite to avoid triggering the human immune system is to activate the SHP-1 protein.

11 Dec 2020

WVU, DHHR team up to create new COVID-19 testing laboratory in Morgantown

To address the challenges of COVID-19 testing shortages and lagging turnaround times, West Virginia University and the West Virginia Department of Health and Human Resources have teamed up to create a new testing laboratory at the Health Sciences Center thanks to funding made possible by Gov. Jim Justice.

11 Dec 2020

Case study suggests kindergartens are not SARS-CoV-2 super-spreaders

A new study by researchers at the Institute of Tropical Medicine and International Health at the Charite Universitaetsmedizin Berlin found that kindergartens are not silent transmission reservoirs.

11 Dec 2020

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

A new study appearing as a preprint on the medRxiv* browser in December 2020 employs reverse phenotyping technology to explore T cell responses in COVID-19.

10 Dec 2020

Single N primer sufficient for SARS-CoV-2 molecular diagnosis

There is a huge and growing demand for better molecular diagnostic tests for COVID-19, as the pandemic shows few signs of coming under control.

10 Dec 2020

SARS-CoV-2 spike protein mediates acute lung pathology in mice

A study shows that the viral spike protein is adequate by itself to induce macrophage activation in pulmonary tissue and induce acute inflammation.

10 Dec 2020

Researchers develop new serological assay for detection of SARS-CoV-2 antibodies

Researchers at UC Santa Cruz have developed a novel serological assay for the detection of antibodies to SARS-CoV-2, the coronavirus that causes COVID-19.

10 Dec 2020

Could anterior nasal swabs be an effective alternative for SARS-CoV-2 testing?

Researchers from various institutions in Germany and Switzerland recently performed a prospective diagnostic accuracy study, in which they compared professional-collected anterior nasal swabs to nasopharyngeal swabs, using WHO-listed SARS-CoV-2 Ag-RDT (STANDARD Q COVID-19 Ag Test, SD Biosensor) test kits.

10 Dec 2020

Researchers identify new therapeutic target to treat patients with type 1 diabetes

Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes.

9 Dec 2020

UCI researchers develop noninvasive, at-home saliva test to detect COVID-19

Researchers in the Henry Samueli School of Engineering at the University of California, Irvine announced promising results in the development of a noninvasive at-home antigen test to detect the spike of SARS-CoV-2 proteins in saliva.

9 Dec 2020

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

A recent study by US researchers, currently available on the medRxiv preprint server, evaluated several cell-based assays that are under validation for determining correlates of protection in individuals with symptomatic coronavirus disease (COVID-19) and vaccine studies – and demonstrated their high concordance with both live and pseudotyped virions.

9 Dec 2020

Amilorides reduce SARS-CoV-2 viral replication in vitro

A new U.S. study published on the bioRxiv preprint server reports the use of an amiloride-based scaffold that targets a viral RNA structure known to be essential in viral replication in the 5’-untranslated region (UTR) of the virus. The researchers say this heralds the application of these molecules as chemical probes to explore viral biology and produce specific antivirals targeting RNA regions of the coronavirus genome.

8 Dec 2020

High-performing multi-immunoassay for early diagnosis and prognosis of COVID-19

A new study published on the preprint server bioRxiv in December 2020 indicates the ability of anti-SARS-CoV-2 antibody titers and time of induction to differentiate between severe and mild COVID-19 and could lead to the development of a prognostic biomarker for use early in the course of the illness.

8 Dec 2020

Researchers use advanced methods to investigate structure and interactions of proteins

Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins -- that is, using advanced methods for investigating the structure and interactions of proteins within larger molecules.

8 Dec 2020

Antigen News and Research

New method shortens the timeline to generate mice for vaccine research

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

Less sensitive rapid tests may miss asymptomatic/presymptomatic SARS-CoV-2 infection

Epitope “megapools” could help determine role T cell immunity plays in COVID-19

Recovered COVID-19 patients exhibit persistent cellular immunity

Study shows how STAT5 optimizes function of CD4+ T cells to drive antitumor immunity

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

WVU, DHHR team up to create new COVID-19 testing laboratory in Morgantown

Case study suggests kindergartens are not SARS-CoV-2 super-spreaders

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

Single N primer sufficient for SARS-CoV-2 molecular diagnosis

SARS-CoV-2 spike protein mediates acute lung pathology in mice

Researchers develop new serological assay for detection of SARS-CoV-2 antibodies

Could anterior nasal swabs be an effective alternative for SARS-CoV-2 testing?

Researchers identify new therapeutic target to treat patients with type 1 diabetes

UCI researchers develop noninvasive, at-home saliva test to detect COVID-19

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

Amilorides reduce SARS-CoV-2 viral replication in vitro

High-performing multi-immunoassay for early diagnosis and prognosis of COVID-19

Researchers use advanced methods to investigate structure and interactions of proteins

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

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