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Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Specialized immune cells settle permanently in various tissues of the body and build "local task forces". Scientists from Würzburg have now discovered, how these cell populations can renew locally and can adapt to their specific environment.

1 Oct 2020

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

Tumors come in many shapes and forms--curable or deadly, solid or liquid, lodged inside the brain, bone, or other tissues. One thing they all have in common, however, is a knack for molecular deceit.

1 Oct 2020

NIH awards grants for using bioengineered models to improve clinical trial design

Clinical Trials on a Chip researchers plan to build and test common and rare disease models to help improve the clinical trial process.

30 Sep 2020

UM171 molecule saves life of young man suffering from severe aplastic anemia

In a world first, a young man suffering from severe aplastic anemia who could not be helped by standard treatments has been given a life-saving blood transplant with the made-in-Canada UM171 molecule.

30 Sep 2020

A study contradicting the phenotypical relationship between plasmablasts and developing neutrophils

A team of scientists from Australia challenges the findings of a recent study by Wilk et al. demonstrating that plasmablasts transdifferentiate into developing neutrophils in severe coronavirus disease 2019 (COVID-19). The Australian study is currently available on the bioRxiv preprint server.

29 Sep 2020

Vitamin D deficiency during early development can influence metabolic health

Using a zebrafish model, researchers from North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation.

29 Sep 2020

Antibody improves progression-free survival in patients with advanced prostate cancer

An antibody for treating advanced prostate cancer improves progression-free survival in patients with metastasised, castration-resistant prostate cancer.

29 Sep 2020

Marrowquant can quantify multiple bone components in histological images

The bone marrow is the soft tissue inside our bones. Its main role is to produce stem cells that will go on to become various cells of the blood, including white blood cells that fight infections, red blood cells that carry oxygen throughout the body, and platelets that control bleeding.

28 Sep 2020

Study identifies hiding place where tumor cells shelter from chemotherapy in childhood leukemia

The stroma of the choroid plexus is one of the locations within the central nervous system (CNS) that serves as a shelter for tumor cells, allowing them to elude chemotherapy and potentially cause subsequent relapses in childhood acute lymphoblastic leukaemia, according to research led by the Complutense University of Madrid.

25 Sep 2020

Pitt team receives NIH award to optimize tissue-engineered vascular graft design

Just as a climbing plant needs the right trellis to thrive, a small-diameter tissue-engineered vascular graft (TEVG) needs the right scaffold to transform seeded cells into a native-like artery that can save a life.

25 Sep 2020

New drug offers hope for young boys with Duchenne muscular dystrophy

A new drug offers hope for young boys with the progressive neuromuscular disease Duchenne muscular dystrophy (DMD) by potentially offering an alternative to high-dose glucocorticoids that have significant side effects.

25 Sep 2020

New device helps study the reaction of individual cells to mechanical stress

The behavior of cells is controlled by their environment. Besides biological factors or chemical substances, physical forces such as pressure or tension are also involved.

25 Sep 2020

People with musculoskeletal pain report worsening symptoms during lockdown

People with bone, joint and muscle pain saw their symptoms worsen during lockdown - according to new research from the University of East Anglia.

25 Sep 2020

Lack of considerations in cumulative effect of food chemicals could have contributed to increased chronic diseases

Today, a group of health, environmental, and consumer organizations challenged the Food and Drug Administration's (FDA) practice of not accounting for the cumulative health effect of chemicals in the diet when allowing new chemicals in food.

24 Sep 2020

Sexual harassment of women during orthopedic training remains pervasive

More than two-thirds of women orthopedic surgeons report experiencing sexual harassment during their residency training, according to a survey study in Clinical Orthopaedics and Related Research (CORR), a publication of The Association of Bone and Joint Surgeons.

23 Sep 2020

Targeted treatment for systemic lupus erythematosus

A team of researchers from Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, have successfully treated two patients with the autoimmune disease systemic lupus erythematosus.

22 Sep 2020

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a new study led by City of Hope and other renowned comprehensive cancer centers.

22 Sep 2020

Bioarchaeology research shows how infectious diseases may have spread 4000 years ago

New bioarchaeology research from a University of Otago PhD candidate has shown how infectious diseases may have spread 4000 years ago, while highlighting the dangers of letting such diseases run rife.

21 Sep 2020

Machine-learning algorithm can detect early, subtle signs of osteoarthritis

Researchers at the University of Pittsburgh School of Medicine and Carnegie Mellon University College of Engineering have created a machine-learning algorithm that can detect subtle signs of osteoarthritis- too abstract to register in the eye of a trained radiologist- on an MRI scan taken years before symptoms even begin.

21 Sep 2020

Bone News and Research

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

NIH awards grants for using bioengineered models to improve clinical trial design

UM171 molecule saves life of young man suffering from severe aplastic anemia

A study contradicting the phenotypical relationship between plasmablasts and developing neutrophils

Vitamin D deficiency during early development can influence metabolic health

Antibody improves progression-free survival in patients with advanced prostate cancer

Marrowquant can quantify multiple bone components in histological images

Study identifies hiding place where tumor cells shelter from chemotherapy in childhood leukemia

Pitt team receives NIH award to optimize tissue-engineered vascular graft design

New drug offers hope for young boys with Duchenne muscular dystrophy

New device helps study the reaction of individual cells to mechanical stress

People with musculoskeletal pain report worsening symptoms during lockdown

Lack of considerations in cumulative effect of food chemicals could have contributed to increased chronic diseases

Sexual harassment of women during orthopedic training remains pervasive

Targeted treatment for systemic lupus erythematosus

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

Bioarchaeology research shows how infectious diseases may have spread 4000 years ago

Machine-learning algorithm can detect early, subtle signs of osteoarthritis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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