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Lab study shows effectiveness of potential therapy for treatment-resistant hypothyroidism

A new "metal-coordinated" drug-delivery technology potentially could be used to supplement the standard therapy for hypothyroidism, which affects nearly 10 million Americans, and many more patients worldwide, according to results of a study published in the journal Thyroid this month.

15 Oct 2018

Rapid inactivation of MRSA superbugs using a simple LED array

Purdue University researchers are testing whether a light-active version of heme, the molecule responsible for transporting oxygen in blood circulation, may help people infected with MRSA.

12 Oct 2018

Researchers uncover how common pain reliever causes liver failure

Acetaminophen is a common pain reliever found in every pharmacy. However, it is also the No. 1 cause of acute liver failure in the United States. In the liver, acetaminophen is converted into a new compound that covalently binds to proteins at an amino acid called cysteine.

11 Oct 2018

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Carnegie's Department of Embryology scientist Steven Farber and team have been awarded a 5-year $3.3-million NIH grant to identify novel pharmaceuticals for combatting a host of diseases associated with altered levels of lipoproteins like LDL ("bad cholesterol").

11 Oct 2018

Color-changing contact lens could help doctors to monitor eye disease medications

For all the good they do, eye drops and ointments have one major drawback: It's hard to tell how much of the medication is actually getting to the eye.

11 Oct 2018

UNC researchers awarded $3.8 million grant to develop ultra-long-acting antiretroviral formulations

It has been well established that HIV transmission can be efficiently halted by effective treatment of those infected or by pre-exposure prophylaxis of individuals at risk of exposure.

11 Oct 2018

Two related enzymes have opposing roles in heart failure

Two related enzymes have opposing roles in mouse heart muscle cells exposed to pressure overload, according to a recent study published in the Proceedings of the National Academy of Sciences, USA.

9 Oct 2018

Joint research team discovers potential new treatment for severe malaria

Scientists from Massachusetts Institute of Technology, Singapore-MIT Alliance for Research and Technology and Nanyang Technological University, Singapore have discovered a potential treatment that could be effective against severe malaria and even drug-resistant malaria.

8 Oct 2018

Common herbicide compound could help fight hospital-acquired fungal infections

A chemical compound found in common herbicides could help fight hospital-acquired human fungal pathogenic infections, which claim an estimated two million lives per year.

4 Oct 2018

Stevens researchers develop new class of molecules for breast cancer treatment

Researchers at Stevens Institute of Technology and colleagues have designed and developed a new class of molecules that use a never-before-known mechanism that may halt or destroy breast cancer tumors, particularly for patients with drug-resistant or dangerously metastatic stages of the disease.

4 Oct 2018

Previously unknown genetic causes of mitochondrial diseases identified

An international team of scientists led by researchers from the University of Colorado School of Medicine have identified previously unknown genetic causes of mitochondrial diseases.

3 Oct 2018

Newly discovered compounds may explain whole grain health benefits

Scientists have discovered new compounds that may explain whole grain health benefits, reports a new study led by the University of Eastern Finland.

3 Oct 2018

Treating aged mice with natural product appears to have positive effects on health and lifespan

Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life.

3 Oct 2018

Natural compound found in grapes may protect against cancer

Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed.

3 Oct 2018

Pesticides used in food, tobacco products place children and smokers in potential risk

Pesticides used in food, tobacco and marijuana production are placing children and smokers in potential risk, a study has found.

3 Oct 2018

New, more efficient method for generating brain stem cells in the lab

In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory.

1 Oct 2018

Researchers deplete key protein for DNA replication using protein degradation system

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system.

29 Sep 2018

Adolescent marijuana users have used the drug in more than one form, research shows

Most teens who've tried marijuana have used the drug in more than one form, including cannabis products that are smoked, eaten or vaped, new USC research shows.

28 Sep 2018

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

FLX Bio, Inc., a clinical-stage, biopharmaceutical company focused on the development of oral small-molecule drugs that target drivers of cancer and other immune-related disorders, today announced that the first patient has been treated in its Phase 1/2 clinical trial of FLX475 in patients with various advanced cancers. FLX475 is an oral, small molecule CCR4 antagonist that selectively inhibits migration of regulatory T cells into the tumor microenvironment.

27 Sep 2018

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

Decibel Therapeutics and Oricula Therapeutics today announced that Decibel has obtained an exclusive, worldwide license to the development and commercialization of ORC-13661, an oral medication developed by Oricula Therapeutics for the prevention of hearing loss and balance disorders that can occur following treatment of severe infections with aminoglycoside antibiotics.

27 Sep 2018

Compound News and Research

Lab study shows effectiveness of potential therapy for treatment-resistant hypothyroidism

Rapid inactivation of MRSA superbugs using a simple LED array

Researchers uncover how common pain reliever causes liver failure

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Color-changing contact lens could help doctors to monitor eye disease medications

UNC researchers awarded $3.8 million grant to develop ultra-long-acting antiretroviral formulations

Two related enzymes have opposing roles in heart failure

Joint research team discovers potential new treatment for severe malaria

Common herbicide compound could help fight hospital-acquired fungal infections

Stevens researchers develop new class of molecules for breast cancer treatment

Previously unknown genetic causes of mitochondrial diseases identified

Newly discovered compounds may explain whole grain health benefits

Treating aged mice with natural product appears to have positive effects on health and lifespan

Natural compound found in grapes may protect against cancer

Pesticides used in food, tobacco products place children and smokers in potential risk

New, more efficient method for generating brain stem cells in the lab

Researchers deplete key protein for DNA replication using protein degradation system

Adolescent marijuana users have used the drug in more than one form, research shows

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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