Laboratory News and Research

RSS

MicroCT-based virtual histology

Utah and Texas researchers combined miniature medical CT scans with high-tech computer methods to produce detailed three-dimensional images of mouse embryos - an efficient new method to test the safety of medicines and learn how mutant genes cause birth defects or cancer.

8 May 2006

Mutated gene leads to JSRD

The research team, directed by Joseph Gleeson, M.D., Director of the Neurogenetics Laboratory at the UCSD School of Medicine and associate professor in the Department of Neurosciences, have identified a new gene that, when mutated, leads to JSRD. Their findings will be published on-line in advance of publication in the journal Nature Genetics.

8 May 2006

Advocacy group has win in terminally ill fight for access to experimental drugs

The Washington Legal Foundation (WLF) and the advocacy group Abigail Alliance, have been successful in the U.S. Court of Appeals.

3 May 2006

Melatonin, taken orally can improve ability to sleep

Researchers from the Divisions of Sleep Medicine at Brigham and Women's Hospital and Harvard Medical School have found in a double-blind placebo-controlled clinical study, that melatonin, taken orally during non-typical sleep times, significantly improves an individual's ability to sleep.

3 May 2006

Differential effects of HOXB4 on nonhuman primate short and long-term repopulating cells

Transplantation of hematopoietic stem cells (HSCs, the cells that can give rise to all blood and most immune cell types) can save patients whose own hematopoietic system is defective or has been destroyed (often through radiation or chemotherapy of cancer).

3 May 2006

Scientists create leaner and meaner E. coli

By stripping the E. coli genome of vast tracts of its genetic material - hundreds of apparently inconsequential genes - a team of Wisconsin researchers has created a leaner and meaner version of the bacterium that is a workhorse of modern biology and industry.

3 May 2006

Identification of CPT1c gene that the brain needs to manage body weight

Working with genetically engineered mice, Johns Hopkins scientists have interfered with the brain's ability to control an animal's response to a high-fat diet.

3 May 2006

Study looks at the cellular basis for immune activation in fatigued breast cancer survivors

Breast cancer survivors who suffer from persistent, debilitating fatigue years after their diagnosis have something in common: their immune systems don't shut down following treatment, according to researchers at UCLA's Jonsson Cancer Center.

3 May 2006

Combined pharmacotherapies and behavioral interventions for alcohol dependence

While many treatment approaches were found helpful, the authors report that the patients who were most successful in abstaining from alcohol 16 weeks after treatment were those prescribed naltrexone under medical management and those participating in a multi-session program of alcohol counseling delivered by a behavioral specialist.

3 May 2006

Polymer-based therapy for breast cancer

Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery.

3 May 2006

Epstein-Barr virus may trigger multiple sclerosis

Researchers have found that patients with multiple sclerosis (MS) carry a population of immune cells that overreact to Epstein-Barr virus.

3 May 2006

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

3 May 2006

Potentially powerful tool for designing novel Alzheimer's treatments

Researchers have identified a protein that reins in the rogue activity of the molecules that make the amyloid-beta protein--which may prevent normal brain function in people with Alzheimer's disease. Their findings reveal a potentially powerful tool for designing novel Alzheimer's treatments.

3 May 2006

Genetic and environmental factors impact chronic fatigue syndrome patients

People who suffer from chronic fatigue syndrome (CFS) have a genetic make up that affects the body's ability to adapt to change, according to a series of papers released last week by the Centers for Disease Control and Prevention (CDC).

2 May 2006

Method by which Caspase-12 shuts down the body's immune system discovered

Caspase-12 is a molecule with a death-wish. Found only in people of African descent, this protein shuts down our body's immune system, opening the door to potentially lethal infections. In a groundbreaking new study published in the prestigious journal Nature this week, the team that first discovered the role of caspase-12 in humans has now uncovered the mechanism by which it sabotages us, allowing researchers to develop methods to counter its damaging effects.

28 Apr 2006

New theory on how the brain detects motion

Researchers at the Salk Institute for Biological Studies have discovered a neural circuit that is likely to play an important role in the visual perception of moving objects. Their finding, published in the April issue of the journal Neuron, forces neurobiologists to rethink the neural pathways that our brain relies on to detect motion.

28 Apr 2006

HCM detection rates doubled when genetic testing and imaging information are combined

Currently that genetic test correctly detects HCM only 40 percent of the time. But coupled with imaging information, the detection power of the test nearly doubles, to 79 percent, says Steve Ommen, M.D., director of Mayo's HCM Clinic and co-lead investigator of the Mayo Clinic research team.

28 Apr 2006

Transplanted stem cells hoped to be able to regenerate damaged heart muscle in first heart attack victims

Rush cardiologists are hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue.

28 Apr 2006

Combinatorial approach found to reverse the onset of type 1 diabetes

A major finding, which represents an important step toward a potential cure for type 1 (insulin-dependent) diabetes, has been made by a research team at the La Jolla Institute for Allergy & Immunology (LIAI). The team, led by Matthias von Herrath, M.D., an internationally recognized expert on the molecular basis of type 1 diabetes, used a combinatorial treatment approach in laboratory mice and found it reversed recent onset type 1 diabetes in the majority of animals tested.

28 Apr 2006

Researchers figure out how nuclear pores duplicate before cells divide

Researchers have long wondered how nuclear pores - the all-important channels that control the flow of information in and out of a cell's nucleus - double in number to prepare for the split to come when a cell divides. Now, for the first time, scientists at the Salk Institute for Biological Studies watched as new funnel-like pore structures formed from scratch, and inserted themselves into the nuclear membrane.

28 Apr 2006