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Scientists develop fenugreek-based nanoparticles to enhance diabetes drug effectiveness

Researchers explored L-arginine-loaded lipid nanoparticles from fenugreek seed oil, finding they enhance drug stability and bioavailability, showing promise for diabetes treatment.

2 Mar 2025

Lactylation in the heart reveals key insights into cardiac regeneration

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

28 Feb 2025

Scientists uncover how a sugar shield in brain blood vessels protects against aging and disease

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain barrier, leading to increased permeability, neuroinflammation, and cognitive decline in aging and neurodegenerative diseases.

27 Feb 2025

New AI model revolutionizes cell structure segmentation in microscopy

Identifying and delineating cell structures in microscopy images is crucial for understanding the complex processes of life.

26 Feb 2025

Breakthrough computational tool enhances design of targeted antiviral therapies

Viruses, like those that cause COVID-19 or HIV, are formidable opponents once they invade our bodies. Antiviral treatments strive to block a virus or halt its replication.

17 Feb 2025

Researchers uncover the brain mechanism behind ketamine's action

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic.

14 Feb 2025

Harvard researchers map 70,000 synaptic connections in rat brain

Harvard researchers have mapped and catalogued more than 70,000 synaptic connections from about 2,000 rat neurons, using a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons.

14 Feb 2025

Diabetes plays key role in the emergence and expansion of antibiotic resistance

Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their dependability has waned as antibiotic resistant bacteria continues to evolve and spread.

12 Feb 2025

EMBL researchers reveal new structural insights into minor spliceosome function

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as you read these lines.

12 Feb 2025

Novel biomarker for early prevention of Alzheimer’s disease

New serine biomarkers show promise for early Alzheimer's detection, linking tau assemblies to cognitive decline and offering potential for timely intervention.

11 Feb 2025

Single dose of antibody shields macaques from severe H5N1 influenza

National Institutes of Health (NIH) scientists and their colleagues report that a single dose of a broadly neutralizing antibody (bnAb) administered prior to virus exposure protects macaques from severe H5N1 avian influenza.

11 Feb 2025

Influenza A virus changes shape to evade immune responses

Influenza A virus particles strategically adapt their shape-to become either spheres or larger filaments-to favor their ability to infect cells depending on environmental conditions, according to a new study from National Institutes of Health (NIH) scientists.

10 Feb 2025

Bionic skin technology provides advanced tactile recognition and visualization capabilities

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2025.240152, discusses how multi-photon bionic skin realizes high-precision haptic visualization for reconstructive perception.

8 Feb 2025

New discovery links brain and muscle cells in signal transmission

Our biceps and our brain cells may have more in common than previously thought.

8 Feb 2025

Collagen's structural diversity may be greater than previously believed, study suggests

Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues.

7 Feb 2025

Research disproves persister bacteria as main cause of antibiotic resistance

Antibiotics are indispensable for treating bacterial infections. But why are they sometimes ineffective, even when the bacteria are not resistant? In their latest study published in the journal Nature, researchers from the University of Basel challenge the conventional view that a small subset of particularly resilient bacteria are responsible for the failure of antibiotic therapies.

5 Feb 2025