Endoplasmic reticulum (ER) News and Research

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DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

16 Jun 2015

Weill Cornell scientists reveal how XBP1 gene can trigger immune responses against ovarian tumors

Ovarian cancer shuts down immune system cells that would otherwise act as a first line of defense against the deadly tumor, Weill Cornell Medical College scientists report today. But a therapy that restores the cells' disease-fighting abilities could provide a powerful new strategy to attack the cancer, which kills more than 14,000 women each year.

12 Jun 2015

Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

Quality control is important - this is not only applicable to industrial production but also true for all life processes. However, whereas an enterprise can start a large-scale recall in case of any doubt, defects in the quality control systems of cells are often fatal.

9 Jun 2015

New York State lawmakers lend critical helping hand to CARE Act

New York State lawmakers lent a critical helping hand today to millions of family caregivers and those for whom they care by giving final legislative passage to the CARE Act, top priority legislation for AARP that will help New Yorkers age safely at home.

2 Jun 2015

Genesis Rehab Services forms groundbreaking partnership with Zhejiang Bang-Er Medical Group

Genesis Rehab Services, a division of Genesis HealthCare, one of the nation's largest providers of post-acute care, today announced a groundbreaking partnership with Zhejiang Bang-Er Medical Group, an orthopedic hospital system in China.

2 Jun 2015

Researchers identify previously unknown gene mutation that causes achromatopsia

People with achromatopsia, an inherited eye disorder, see the world literally in black and white. Worse yet, their extreme sensitivity to light makes them nearly blind in bright sunlight. Now, researchers at University of California, San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health System have identified a previously unknown gene mutation that underlies this disorder.

2 Jun 2015

Previously unknown gene mutation linked to inherited eye disorder, achromatopsia

2 Jun 2015

Caris Molecular Intelligence allows comparisons between tumors sharing histological features

Caris Life Sciences, a leading biotechnology company focused on fulfilling the promise of precision medicine, today announced the presentation of data from three studies that demonstrate the utility of Caris Molecular Intelligence®, the company's panomic comprehensive tumor profiling service, in facilitating comparisons between tumors that share histological features.

1 Jun 2015

Researchers identify key driver mutations in glioma samples that confirm tumor heterogeneity

Caris Life Sciences today announced the presentation of data from a study in which researchers identified biomarker changes, including key driver mutations, in 89% of metachronous paired glioma tumors, indicating changes in response to therapy as the disease progresses.

1 Jun 2015

Novartis to highlight strength of its expanded oncology portfolio at ASCO 2015

Novartis will highlight the strength of its expanded oncology portfolio in 21 medicines and 11 investigational compounds across more than 185 data presentations at the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting, May 29-June 2, and the Congress of the European Hematology Association (EHA), June 11-14.

1 Jun 2015

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Myriad Genetics, Inc. today announced it will highlight several new clinical studies on its myRisk Hereditary Cancer molecular diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

30 May 2015

Rapid-deployment plasma protocol helps treat trauma victims faster in the ER

Traumatic injury is the leading cause of death among people under age 45, but if trauma physicians could deliver plasma to these injury victims within minutes of their arrival in the emergency room, more of them would stand a better chance of survival.

29 May 2015

Emergency medicine faces special challenges with changeover in medical diagnosis codes

Emergency medicine faces special challenges during this fall's changeover in how medical diagnoses are coded. Nearly a quarter of all ER clinical encounters could pose difficulties.

27 May 2015

Study reveals molecular basis for endocrine therapy-resistant breast cancer

Mitsuyoshi Nakao, Director of the Institute of Molecular Embryology and Genetics in Kumamoto University and Associate Professor Noriko Saitoh revealed that a cluster of defined, non-coding RNAs are mechanistically involved in endocrine therapy resistance in human breast cancer cells. Furthermore, resveratrol, a kind of polyphenol, was found to repress these RNAs and inhibit the proliferative activity of breast cancer cells which had acquired resistance.

27 May 2015

Alternative generic strategy for breast cancer treatment

Maxing out the inherently stressed nature of treatment-resistant breast cancer cells thwarts their adaptive ability to evolve genetic workarounds to treatment, a new study suggests.

27 May 2015

FDA accepts Tris Pharma's Dyanavel XR NDA for review

Tris Pharma, Inc. announced that U.S. Food and Drug Administration has accepted for review its New Drug Application ("NDA") for Dyanavel XR (amphetamine) CII, an Extended-Release Oral Suspension.

21 May 2015

Neighbors Emergency Center announces opening of new center in Crosby, Texas

Neighbors Emergency Center announced today the opening of its new Crosby, Texas location. The new 24 hour free-standing emergency center hosted its Grand Opening celebration on Friday, May 8, 2015.

11 May 2015

Innovative, active post-discharge intervention program benefits thoracic surgery patients

Post-surgical hospital readmission after discharge and repeat emergency room (ER) visits are not unusual for patients who have undergone major thoracic surgery. Recognizing this problem, clinicians at McMaster University have implemented an innovative, active post-discharge intervention for thoracic surgery patients that is based on the principle of a "one team-one approach" that is initiated while the patient is still hospitalized.

29 Apr 2015

Blue Cross Blue Shield of Michigan, UMHS collaborate to improve quality of care for Michiganians

Blue Cross Blue Shield of Michigan and the University of Michigan Health System will collaborate with emergency physicians at participating hospitals across the state to develop best practices to improve the experience and outcomes of patients receiving care in emergency departments.

21 Apr 2015

New combination therapy could overcome treatment resistance, relapse in breast cancer

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.

21 Apr 2015

Endoplasmic reticulum (ER) News and Research

DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

Weill Cornell scientists reveal how XBP1 gene can trigger immune responses against ovarian tumors

Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

New York State lawmakers lend critical helping hand to CARE Act

Genesis Rehab Services forms groundbreaking partnership with Zhejiang Bang-Er Medical Group

Researchers identify previously unknown gene mutation that causes achromatopsia

Previously unknown gene mutation linked to inherited eye disorder, achromatopsia

Caris Molecular Intelligence allows comparisons between tumors sharing histological features

Researchers identify key driver mutations in glioma samples that confirm tumor heterogeneity

Novartis to highlight strength of its expanded oncology portfolio at ASCO 2015

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Rapid-deployment plasma protocol helps treat trauma victims faster in the ER

Emergency medicine faces special challenges with changeover in medical diagnosis codes

Study reveals molecular basis for endocrine therapy-resistant breast cancer

Alternative generic strategy for breast cancer treatment

FDA accepts Tris Pharma's Dyanavel XR NDA for review

Neighbors Emergency Center announces opening of new center in Crosby, Texas

Innovative, active post-discharge intervention program benefits thoracic surgery patients

Blue Cross Blue Shield of Michigan, UMHS collaborate to improve quality of care for Michiganians

New combination therapy could overcome treatment resistance, relapse in breast cancer

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