Peptides News and Research

RSS

New analytical method for identifying cancer cell targets

What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies. Scientists from the German Cancer Research Center (DKFZ) and the NCT Heidelberg are publishing a highly sensitive method based on mass spectroscopy to identify such tumor-specific "neoepitopes". The analytical method is designed to detect these low-abundance protein fragments and requires minimal amounts of sample material.

23 Aug 2024

Cancer drug holds promise as a new treatment for neurodegenerative diseases

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.

22 Aug 2024

Gut molecule blocks fat burning during fasting in C. elegans

In a struggle that probably sounds familiar to dieters everywhere, the less a Caenorhabditis elegans (C. elegans) worm eats, the more slowly it loses fat.

21 Aug 2024

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain.

21 Aug 2024

Understanding gluten's role in autoimmunity and inflammation

The interaction between humans and their environment, mediated by nutrition, plays a crucial role in regulating inflammatory responses.

21 Aug 2024

Uncovering new antibiotics from the human gut microbiome

The average human gut contains roughly 100 trillion microbes, many of which are constantly competing for limited resources.

19 Aug 2024

Cross-reactive T cells link SARS-CoV-2 to autoimmune triggers in MIS-C

Research identifies cross-reactive T cells targeting both SARS-CoV-2 and human SNX8 protein, providing insights into the autoimmune mechanisms driving MIS-C in children.

8 Aug 2024

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

In this interview conducted at Pittcon 2024, we spoke to Professor John Yates about capturing cardiomyocyte cell-to-cell heterogeneity via shotgun top-down proteomics.

From Pittcon 6 Aug 2024

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to evaluate the safety and effectiveness of a cancer vaccine targeting H3 G34-mutant diffuse hemispheric glioma, a highly aggressive brain tumor that is typically found in adolescents and young adults.

5 Aug 2024

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Research highlights how cholesterol imbalances in the brain contribute to neurodegenerative diseases like Alzheimer's, Huntington's, and Parkinson's, suggesting targeted therapeutic interventions.

5 Aug 2024

Groundbreaking method dmSLAY improves antimicrobial peptide effectiveness and safety

Researchers developed a high-throughput method, dmSLAY, to assess thousands of AMP variants, combining it with machine learning to enhance membrane selectivity and reduce toxicity.

1 Aug 2024

AI unlocks potential of antimicrobial peptides for new antibiotics

In a hopeful sign for demand for more safe, effective antibiotics for humans, researchers at The University of Texas at Austin have leveraged artificial intelligence to develop a new drug that already is showing promise in animal trials.

1 Aug 2024

Machine learning-based taste predictor developed for identifying bitter, sweet, and umami from other taste sensations

Researchers developed VirtuousMultiTaste, a machine-learning tool to distinguish between sweet, umami, and bitter tastes based on a compound's molecular structures and underlying physicochemical characteristics.

31 Jul 2024

GLP-1-based polyagonists: A promising weight loss alternative to bariatric surgery

Researchers highlight the unprecedented success of GLP-1-based multi-receptor drugs in achieving substantial weight loss and improved health outcomes, potentially replacing bariatric surgery for obesity treatment.

28 Jul 2024

Study reveals enhanced electron transport in folded peptides

What puts the electronic pep in peptides? A folded structure, according to a new study in the Proceedings of the National Academy of Sciences.

26 Jul 2024

New review highlights advances in diabetes research and treatment

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

25 Jul 2024

Oligodendrocytes identified as key source of amyloid beta in Alzheimer's disease

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues.

23 Jul 2024

Beyond the anti-obesity benefits of glucagon-like peptide-1 drugs

The advantages of glucagon-like peptide-1 (GLP-1) medicines beyond glycemic and weight control.

23 Jul 2024

New microscopy technique unveils dynamic structure of amyloid-beta

Amyloid-beta (A-beta) aggregates are tangles of proteins most notably associated with neurodegenerative diseases like Alzheimer's.

19 Jul 2024

Tiny animals steal antibiotic secrets from bacteria to fight disease

A group of small, freshwater animals protect themselves from infections using antibiotic recipes "stolen" from bacteria, according to new research by a team from the University of Oxford, the University of Stirling and the Marine Biological Laboratory (MBL), Woods Hole.

19 Jul 2024