Prion News and Research

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Oral vaccine prevents prion disease in mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research presented at the American Academy of Neurology's 59th Annual Meeting in Boston.

4 May 2007

Disease associated prion protein oligomers inhibit the 26S proteasome

The rogue prion proteins responsible for diseases like BSE and vCJD can destroy brain cells by blocking the protein recycling process that helps keep cells healthy.

27 Apr 2007

UK scientists reverse symptoms of mad cow disease

The researchers at University College, London, believe they have found a way to treat the disease in humans as long as it is detected before it has done harm to a large number of brain cells.

1 Feb 2007

Effects of prion disease could be reversed if caught early enough

The researchers said that their findings support developing early treatments that aim to reduce levels of prion protein in the brains of people with prion disease.

31 Jan 2007

Single protein plays a major role in prion diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

23 Jan 2007

Health officials accused over cover up in deaths from vCJD

A cover up on the part of British health authorities meant a man who had been infected with CJD from contaminated blood during a transfusion was not told until he was dying what was really wrong with him.

11 Dec 2006

CJD closes operating theatres in Canada

All surgery at a hospital in Ontario Canada has been halted after it was discovered that a patient undergoing neurosurgery on November 30th may have had the fatal brain-wasting disease Creutzfeldt-Jakob (CJD).

6 Dec 2006

Fat droplets play protective role inside cells

Too much body fat may be a bad thing, but there is increasing evidence that too little fat also may have some surprisingly negative consequences.

19 Sep 2006

New aspect of prion disease - agent causes heart damage

Until now, prion disease has been thought of as a chronic neurological condition.

9 Jul 2006

New discovery boosts basic understanding of prion infections

Brittleness is often seen as a sign of fragility. But in the case of infectious proteins called prions, brittleness makes for a tougher, more menacing pathogen.

28 Jun 2006

The protein that makes you mad

In recent years our feeding habits have been the focus of ongoing polemics. Everybody will remember the "mad cow" crisis.

26 Jun 2006

No prion diseases found in German deer

Presently, there is no evidence of prion diseases in free-living German cervids.

19 Jun 2006

New human genotype may be prone to vCJD

A small study in the British Medical Journal suggests a new human genotype may be prone to variant Creutzfeldt-Jakob disease (vCJD).

6 Jun 2006

vCJD may have infected far more people than previously thought

Scientists at the National CJD Surveillance Unit at the University of Edinburgh say that thousands may be infected with variant Creutzfeldt-Jakob Disease (vCJD) without showing signs or symptoms.

21 May 2006

Certain soil types serve as natural prion repositories in the wild

Scientists have confirmed that prions, the mysterious proteins thought to cause chronic wasting disease (CWD) in deer, latch on tightly to certain minerals in soil and remain infectious.

18 Apr 2006

Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

4 Apr 2006

New evidence questions the simple link between prion proteins and vCJD

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

30 Mar 2006

New way of targeting proteins to exosomes - potential for melanoma, Alzheimer's disease

Researchers at the University of Pennsylvania School of Medicine have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually sequesters melanin, the dark pigment found in skin, hair, and eyes.

28 Mar 2006

Successful cell engineering may prevent bovine spongiform encephalopathy (BSE)

Researchers at Texas A&M University have successfully "knocked down" the expression of possible disease-causing genes in a cloned goat fetus, perhaps paving the way for breeding disease resistance in other animals, even those genes that might cause bovine spongiform encephalopathy (BSE), commonly known as Mad Cow Disease.

23 Mar 2006

New test for detecting small amounts of proteins in the blood

Researchers at the University of Pennsylvania School of Medicine have developed a paradigm-shifting method for detecting small amounts of proteins in the blood.

13 Mar 2006