Protein C News and Research

RSS

Deficient ATP release in the brain drives depressive- and anxiety-like behaviors

In a new JNeurosci paper, Tian-Ming Gao and colleagues, from Southern Medical University, explored how adenosine triphosphate (ATP) signaling relates to depression and anxiety using male mice. ATP is a molecule that not only provides energy but also supports communication between neurons.

25 Nov 2025

Study reveals metabolic benefits of reducing ultra-processed foods in older adults

A controlled feeding study out of South Dakota State University shows that older adults who ate fewer ultra-processed foods naturally consumed fewer calories, lost weight and abdominal fat, and showed improvements in insulin, nutrient-sensing hormones, and inflammation.

24 Nov 2025

Calcium-activated switch improves delivery and potency of cancer-fighting drugs

Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too often they don't make it that far.

24 Nov 2025

Discovery reveals role of EGFR in resistance to KRAS inhibitors in pancreatic cancer

A study led by University of Cincinnati Cancer Center researchers sheds new light on how pancreatic cancer cells resist treatment and points to potential new combination therapies to make treatments more effective.

24 Nov 2025

Study introduces cost-effective approach to analyze entire T-cell repertoire

Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children's Research Hospital.

24 Nov 2025

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.

24 Nov 2025

New insights into ribosome collisions and stress response

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

24 Nov 2025

Identifying vulnerabilities and new targets for hard-to-treat carcinomas

Some tumors are almost impossible to treat. That's especially true for carcinomas, which don't behave like other malignancies.

24 Nov 2025

Elevated levels of five blood proteins can help predict mortality risk

Elevated levels of five proteins in our blood can help predict risk of mortality, a new study from the University of Surrey finds.

24 Nov 2025

Kennedy sharpens vaccine attacks, without scientific backing

As the federal government prepares for the next meeting of its Advisory Committee on Immunization Practices, Health and Human Services Secretary Robert F. Kennedy Jr. has intensified his attacks on aluminum vaccine components used in many shots to boost the body's immune response.

24 Nov 2025

Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics-meticulously placed chemical tags that influence which genes are expressed in each cell.

22 Nov 2025

Research explores new solvent strategies to extend shelf life of injectable therapeutics

Sugar-based liquid solvents store crucial injection-based therapeutics such as insulin and vaccines.

22 Nov 2025

New signaling molecule drives development of tissue resident memory T cells

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body's first responders to disease.

22 Nov 2025

Promising long-term vaccine for Crimean-Congo hemorrhagic fever developed

Crimean-Congo hemorrhagic fever (CCHF) is one of the world's most dangerous yet overlooked infectious diseases.

22 Nov 2025

Study uncovers role of mechanical forces in human gastrulation

Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human body (head/tail, ventral/dorsal, and right/left) begins to appear.

22 Nov 2025

Comprehensive antibody map reveals how SARS-CoV-2 mutations evade immunity

Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have created the most comprehensive map to date showing how antibodies attach to the SARS-CoV-2 virus, which causes COVID-19, and how viral mutations weaken that attachment.

21 Nov 2025

Scientists identify cellular control points to tackle multiple viruses

Scientists were pleased when they learned more about how the common cold gains a foothold in the body, identifying key cellular checkpoints that are important targets of the virus.

21 Nov 2025

Immune system abnormalities identified as core mechanism in major depressive disorder

Major depressive disorder (MDD) is characterized by a lowered mood and loss of interest, contributing not only to difficulties in academic and professional life but also as a major cause of suicide in South Korea.

21 Nov 2025

Oral arginine reduces amyloid buildup in Alzheimer’s models

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is one of the leading causes of dementia worldwide, and currently has no definitive cure. Although antibody-based therapies that target amyloid β (Aβ) have recently been developed, their clinical effectiveness remains limited.

21 Nov 2025

Study clarifies how spermine can guard against Alzheimer’s and Parkinson’s

Researchers at the Paul Scherrer Institute PSI have clarified how spermine - a small molecule that regulates many processes in the body's cells - can guard against diseases such as Alzheimer's and Parkinson's: it renders certain proteins harmless by acting a bit like cheese on noodles, making them clump together.

21 Nov 2025