Signaling Pathway News and Research

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METRNL protein identified as key player in cancer progression

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Finding ways to block the effects of METRNL signaling on tumor-infiltrating T cells may allow these immune cells to regain the energy necessary to eliminate tumors.

7 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

Breakthrough research identifies pathway used by glioblastoma to infiltrate the brain

A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University.

2 Aug 2024

Genetic loss of miR-205 boosts mammary gland development in mice, reveals new insights into breast cancer suppression

Genetic loss of miR-205 in mice enhances mammary gland development and branching, challenging previous lethality findings and highlighting its onco-suppressive functions.

30 Jul 2024

Researchers identify key genetic variants linked to ALS recovery

Though exceedingly rare, some people diagnosed with amyotrophic lateral sclerosis (ALS) partially or fully recover from the lethal neurodegenerative disease.

30 Jul 2024

Epigenetic reprogramming and hypothalamic changes in metabolic syndrome

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population.

30 Jul 2024

Deciphering miRNA-mediated regulation of liver regeneration: New insights

The liver, a vital organ involved in numerous essential physiological processes such as bile production, plasma protein synthesis, nutrient absorption, detoxification, vitamin storage, macronutrient metabolism, and immune support, has a remarkable regenerative capacity.

29 Jul 2024

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Research reveals xanthones as promising agents in diabetes management, offering antioxidant, anti-inflammatory, and insulin-sensitizing benefits.

29 Jul 2024

Innovative dual-drug strategy for colorectal cancer treatment

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed.

27 Jul 2024

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Breakthrough research identifies fibrin as key factor in preterm brain bleeds

Mark Petersen, MD, has seen firsthand the devastating effects of brain bleeds in premature babies. It's an exceedingly common condition that affects up to 20 percent of infants born before 28 weeks of gestation, bringing an increased risk for developmental delays and autism.

24 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Exploring non-coding RNAs as regulators of notch signaling in breast cancer

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis.

23 Jul 2024

Novel peptide PEPITEM shows promise in fighting 'inflammaging'

A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against 'inflammaging', which is widely believed to be the root cause of many age-related diseases.

18 Jul 2024

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells.

18 Jul 2024

CePA: Novel nanomedicine for alleviating MASH via mTOR repression

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases, primarily caused by metabolic disorders and systemic inflammatory responses.

16 Jul 2024

Novel DNA aptamers of melanopsin developed to regulate circadian rhythm

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

12 Jul 2024

Research reveals immune suppression link between cancer and pregnancy

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.

8 Jul 2024

Plant-derived substance shows promise against pulmonary hypertension

A substance derived from the plant Ardisia crenata works in a different way than existing drugs. And in doing so, it is highly effective.

8 Jul 2024

Innovative research sheds light on migraine mechanisms and potential therapies

New research describes for the first time how a spreading wave of disruption and the flow of fluid in the brain triggers headaches, detailing the connection between the neurological symptoms associated with aura and the migraine that follows.

4 Jul 2024