Central Nervous System News and Research

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Electrophysiology: an interview with Dr Kaylene Young

Bioelectricity is an essential part of our make-up. All cells in our body communicate by electrical activity. If an electrical charge is applied to one of our muscles it will interpret that electrical activity as a signal telling it to contract.

21 Nov 2012

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

Scientists at the Mainz University Medical Center have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system.

21 Nov 2012

Ai Cure Technologies presents AiView digital health solution at CNS Summit

New York City-based Ai Cure Technologies opened the Innovation Showcase at CNS Summit in Boca Raton, Fla, with a presentation of its flagship digital health solution, AiView.

19 Nov 2012

BLADE method can help examine children's heads in MRI without general anaesthesia

For the first time, Bochum clinicians have been able to show on the basis of a large sample, that it is possible to examine children's heads in the MRI scanner without general anaesthesia or other medical sedation. In many cases it was sufficient to prepare the young patients for the examination in an age-appropriate manner in order to take away their fear of the tube.

16 Nov 2012

People with Prader-Willi Syndrome may have impaired autonomic nervous system

An Australian study reveals that people with the rare genetic disorder known as Prader-Willi Syndrome may have an impaired autonomic nervous system. This discovery opens up a new way of looking at the insatiable appetite experienced by all sufferers, as well as their very high risk of cardiovascular disease.

16 Nov 2012

Breakthrough treatment for survivors of traumatic brain injury

The first treatment breakthrough of its kind for survivors of traumatic brain injury (TBI) or stroke will be published in the December 1 issue of the journal CNS Drugs, with an accompanying editorial.

15 Nov 2012

Brevetoxin-2 stimulates nerve cell growth and plasticity in cultured mouse neurons

A new study using brevetoxin-2, a compound produced naturally by marine algae, stimulated nerve cell growth and plasticity in cultured mouse neurons. This research advances a potentially new pharmacological treatment to aid recovery of brain function following a stroke or other traumatic brain injury.

14 Nov 2012

Gene variants involved in glutamatergic transmission appear to increase risk of depression

Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.

14 Nov 2012

Nanofiber technique to build new nerves from stem cells

Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.

8 Nov 2012

Caltech-led team discovers enzyme responsible for neural crest cell development

During the early developmental stages of vertebrates-animals that have a backbone and spinal column, including humans-cells undergo extensive rearrangements, and some cells migrate over large distances to populate particular areas and assume novel roles as differentiated cell types.

3 Nov 2012

Some types of bariatric surgery may cause bone loss, say endocrinologists

Bariatric surgery, which significantly curtails the amount of food a person can eat, is the most effective treatment against obesity and is being recognized as a potentially valuable tool in the fight against diabetes related to obesity.

3 Nov 2012

Adding angiogenesis inhibitor to anti-HER2 drugs extends survival in mice with breast cancer

Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases. In their report published online in PNAS Plus, Massachusetts General Hospital (MGH) investigators report the first preclinical study combining antiangiogenic and anti-HER2 drugs in an animal model of brain metastatic breast cancer.

3 Nov 2012

TD-1211 may relieve opioid-induced constipation

TD-1211 – an inhibitor of the mµ-opioid receptor – alleviates chronic noncancer-related constipation in patients receiving opioid therapy, without affecting pain relief, show the results of a parallel-group study.

2 Nov 2012

Researchers unlock complex cellular mechanics that instruct glial progenitor cells to divide

In a new study appearing this month in the Journal of Neuroscience, researchers have unlocked the complex cellular mechanics that instruct specific brain cells to continue to divide. This discovery overcomes a significant technical hurdle to potential human stem cell therapies; ensuring that an abundant supply of cells is available to study and ultimately treat people with diseases.

2 Nov 2012

Study explores impact of IL1β on brain function alterations associated with schizophrenia

There are a growing number of clues that immune and inflammatory mechanisms are important for the biology of schizophrenia. In a new study in Biological Psychiatry, Dr. Mar Fatjó-Vilas and colleagues explored the impact of the interleukin-1β gene (IL1β) on brain function alterations associated with schizophrenia.

2 Nov 2012

Single dose of etanercept can improve chronic neurological dysfunction from stroke or TBI

A new ground-breaking study about to be published in the Adis journal CNS Drugs provides clinical evidence that, for the first time, chronic neurological dysfunction from stroke or traumatic brain injury can rapidly improve following a single dose of a drug that targets brain inflammation, even years after the stroke or traumatic event.

1 Nov 2012

Scientists discover first selective inhibitors of DAGL enzymes

Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based on them, now can be used to study the functions of enzymes known as diacylglycerol lipases (DAGL), their products, and the pathways they regulate.

1 Nov 2012

Additional data from EnVivo’s EVP-6124 Phase 2b trial on AD presented at CTAD meeting

EnVivo Pharmaceuticals, a company dedicated to developing a broad range of novel central nervous system (CNS) therapies, today presented pharmacokinetic and pharmacodynamic data along with the previously reported statistically significant clinical results from its Phase 2b clinical trial of EVP-6124, a novel alpha-7 agonist, in patients with Alzheimer's disease.

1 Nov 2012

Gene variant predicts lymphoma treatment response

German researchers have identified a gene variant that significantly influences the outcome of methotrexate therapy for primary central nervous system lymphoma.

31 Oct 2012

Integra Holdings, a biopharmaceutical holding company, announced by Yissum

Yissum Research and Development Company of the Hebrew University of Jerusalem, the technology transfer company of the Hebrew University, announced today the inception of its subsidiary, Integra Holdings, a holding company focusing on biopharmaceutical companies based on inventions of researchers from the Hebrew University.

31 Oct 2012

Central Nervous System News and Research

Electrophysiology: an interview with Dr Kaylene Young

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

Ai Cure Technologies presents AiView digital health solution at CNS Summit

BLADE method can help examine children's heads in MRI without general anaesthesia

People with Prader-Willi Syndrome may have impaired autonomic nervous system

Breakthrough treatment for survivors of traumatic brain injury

Brevetoxin-2 stimulates nerve cell growth and plasticity in cultured mouse neurons

Gene variants involved in glutamatergic transmission appear to increase risk of depression

Nanofiber technique to build new nerves from stem cells

Caltech-led team discovers enzyme responsible for neural crest cell development

Some types of bariatric surgery may cause bone loss, say endocrinologists

Adding angiogenesis inhibitor to anti-HER2 drugs extends survival in mice with breast cancer

TD-1211 may relieve opioid-induced constipation

Researchers unlock complex cellular mechanics that instruct glial progenitor cells to divide

Study explores impact of IL1β on brain function alterations associated with schizophrenia

Single dose of etanercept can improve chronic neurological dysfunction from stroke or TBI

Scientists discover first selective inhibitors of DAGL enzymes

Additional data from EnVivo’s EVP-6124 Phase 2b trial on AD presented at CTAD meeting

Gene variant predicts lymphoma treatment response

Integra Holdings, a biopharmaceutical holding company, announced by Yissum

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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