Preclinical News and Research

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A strategic collaboration to speed up the development of allogeneic cell therapies

The University of Texas MD Anderson Cancer Center and Allogene Therapeutics, Inc. today announced a strategic five-year collaboration agreement for the preclinical and clinical investigation of AlloCAR T candidates across Allogene's broad portfolio of hematologic and solid tumors.

16 Oct 2020

Tech Spotlight honors ISSCR's stem cell based clinical trials guide

The ISSCR's Stem Cell-Based Clinical Trials: Practical Advice for Physicians and Ethics/Institutional Review Committees was honored today by Tech Spotlight at Harvard Kennedy School's Belfer Center.

16 Oct 2020

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

The COVID-19 pandemic is threatening to come back in greater intensity during the winter and fall. Faced with this threat, vaccine development efforts are entering a phase of renewed focus, attempting to identify antigens capable of eliciting protective levels of neutralizing antibodies. A new study published on the preprint server bioRxiv* in October 2020 reports on a novel mRNA vaccine candidate's performance in two animal models.

16 Oct 2020

Scientists engineer powerful novel anti-microbial molecules from wasp venom

Now, a team of scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered potent novel anti-microbial molecules from toxic proteins found in wasp venom. The researchers believe that the discovery holds promise in fighting the increasing number of antibiotic-resistant bacteria, that cause serious illness.

15 Oct 2020

The COVID-19 vaccine pipeline

Researchers from Mayo Clinic, United States of America, have reviewed the immunity developed against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease.

14 Oct 2020

Researchers are developing a new class of compounds against various cancers

Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and lymphoma.

14 Oct 2020

New clinical cleanroom manufacturing and training facility launches in Brisbane

The Hon Karen Andrews, Minister for Industry, Science and Technology is opening the Translational Research Institute's new state-of-the-art clinical cleanroom manufacturing and training facility, T3 Cleanrooms, and the inaugural MTPCareers Symposium on Wednesday 14 October 2020.

13 Oct 2020

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

13 Oct 2020

Axol Bioscience introduces multi-electrode array screening services for human iPSC-derived cells

Axol Bioscience today announced the expansion of its services, with the introduction of array screening for human induced pluripotent stem cells.

From Axol Bioscience Ltd 13 Oct 2020

Researchers identify a mechanism to prevent hair loss

An international research group headed by Associate Professor Sara Wickström at the University of Helsinki has identified a mechanism that is likely to prevent hair loss.

13 Oct 2020

Eyeglass display device allows surgeon to focus on operative tasks more efficiently

The authors, two surgeon-researchers from Murayama Medical Center in Tokyo, tested a device that, when attached to everyday eyeglasses, can display fluoroscopic images used for surgical guidance directly to the surgeon.

13 Oct 2020

In vitro BA-LRA can help detect small molecule drugs for drug-induced liver injury

BioIVT, a leading provider of research models and services for drug and diagnostic development, today announced the publication of research describing the use of HEPATOPAC® cultures with a targeted in vitro assay to identify small molecule drugs with high potential for drug-induced liver injury (DILI).

13 Oct 2020

COVID-19 vaccine candidate shows potent immune response

A COVID-19 vaccine candidate that underwent extensive preclinical testing at the University of Alabama at Birmingham this spring and summer shows potent preclinical immune responses - including several that distinguish it from other COVID-19 vaccine approaches - according to a preprint deposited in the BioRxiv repository this week.

13 Oct 2020

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

12 Oct 2020

Dopamine and serotonin play role in perception and decision-making

Scientists at Wake Forest School of Medicine have recorded real time changes in dopamine and serotonin levels in the human brain that are involved with perception and decision-making.

12 Oct 2020

Researchers examine the cooperative effects of genes in suppressing neuroendocrine tumors in mice

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

12 Oct 2020

Preclinical News and Research

A strategic collaboration to speed up the development of allogeneic cell therapies

Tech Spotlight honors ISSCR's stem cell based clinical trials guide

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

Scientists engineer powerful novel anti-microbial molecules from wasp venom

The COVID-19 vaccine pipeline

Researchers are developing a new class of compounds against various cancers

New clinical cleanroom manufacturing and training facility launches in Brisbane

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Axol Bioscience introduces multi-electrode array screening services for human iPSC-derived cells

Researchers identify a mechanism to prevent hair loss

Eyeglass display device allows surgeon to focus on operative tasks more efficiently

In vitro BA-LRA can help detect small molecule drugs for drug-induced liver injury

COVID-19 vaccine candidate shows potent immune response

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

Dopamine and serotonin play role in perception and decision-making

Researchers examine the cooperative effects of genes in suppressing neuroendocrine tumors in mice

Developing a precision 'Trojan Horse' nanotherapy to treat breast cancer

Study compares the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Neurobiologists decode central mechanism of degenerative processes in brains of mouse models

Researchers develop mitochondrial-targeted prodrug for treating glioblastoma

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics