Cell Death News and Research

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Findings may help develop biomarkers to identify HIV patients at risk of dementia

Since the introduction of the combination anti-retroviral therapy (cART) in the mid-90s, the life expectancy of HIV patients has significantly improved. As a result, long-term complications are becoming more relevant: almost every second HIV patient is affected by neurocognitive disorders, which can lead to dementia.

4 Sep 2014

Factor in cells of naked mole rats protects activity of proteasome

Scientists at the Barshop Institute for Longevity and Aging Studies, part of the School of Medicine at the UT Health Science Center at San Antonio, have found another secret of longevity in the tissues of the longest-lived rodent, the naked mole rat.

30 Aug 2014

Freiburg biochemists discover new mechanisms of brain disease

The failing in the work of nerve cells: An international team of researchers led by Prof. Dr. Chris Meisinger from the Institute of Biochemistry and Molecular Biology of the University of Freiburg has discovered how Alzheimer's disease damages mitochondria, the powerhouses of the cell.

29 Aug 2014

Researchers find more selective therapies for cancer

Thanks to important discoveries in basic and clinical research and technological advances, the fight against cancer has mobilized into a complex offensive spanning multiple fronts.

25 Aug 2014

Finding suggests that retina acts as type of window to the brain

Researchers at the Gladstone Institutes and University of California, San Francisco have shown that a loss of cells in the retina is one of the earliest signs of frontotemporal dementia (FTD) in people with a genetic risk for the disorder-even before any changes appear in their behavior.

25 Aug 2014

Researchers examine impact of BIM deletion on survival outcomes of advanced NSCLC patients

Bcl-2-like protein 11 (BIM) deletion in advanced non-small cell lung cancer (NSCLC) is associated with shorter progression free survival (PFS) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) or chemotherapy treated Asian patients.

25 Aug 2014

Insulin can protect cells of pancreas from acute pancreatitis

Scientists from The University of Manchester have discovered that insulin can protect the cells of the pancreas from acute pancreatitis - a disease for which there is currently no treatment.

21 Aug 2014

Choroidal consequences differ between anti-VEGF therapies

Aflibercept’s possession of a fragment crystallisable region may make it more likely to induce unwanted effects in retinal and choroidal vessels than other anti-vascular endothelial growth factor therapies, say researchers.

20 Aug 2014

Scientists suggest that type-1 and type-2 diabetes are result of same mechanism

Work by scientists at the Universities of Manchester and Auckland suggest that both major forms of diabetes are the result of the same mechanism.

From The University of Manchester 20 Aug 2014

Research validates Myc inhibition as effective therapeutic strategy for glioma

Research led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma - a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies.

19 Aug 2014

MGH-developed microfluidic device may help study key steps involved in development of tumor metastasis

A microfluidic device developed at Massachusetts General Hospital may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases.

19 Aug 2014

Study suggests autophagy is involved in the onset of vascular dementia

Autophagy is a basic catabolic mechanism by which unnecessary or dysfunctional cellular components are degraded by lysosomes.

12 Aug 2014

Researchers create synthetic ion transporter that triggers apoptosis in cancer cells

Researchers from the University of Southampton are part of an international team that has helped to create a molecule that can cause cancer cells to self-destruct by carrying sodium and chloride ions into the cells.

12 Aug 2014

New drug spurs liver regeneration after surgery

A new drug spurs liver regeneration after surgery, according to a paper published in The Journal of Experimental Medicine.

12 Aug 2014

Researchers discover how arginine starvation specifically kills cancer cells

Researchers at UC Davis, City of Hope, Taipai Medical University and National Health Research Institutes in Taiwan have discovered how a drug that deprives the cells of a key amino acid specifically kills cancer cells.

12 Aug 2014

Researchers create synthetic molecule that can cause cancer cells to self-destruct

Researchers from The University of Texas at Austin and five other institutions have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells.

12 Aug 2014

Researchers find promising technique for type 1 diabetics to restore insulin producing cells

A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has found that a peptide called caerulein can convert existing cells in the pancreas into those cells destroyed in type 1 diabetes-insulin-producing beta cells.

31 Jul 2014

Researchers identify RNA that modulates action of important gene in process of programmed cell death

Researchers from the University of S-o Paulo (USP) have identified an RNA known as INXS that, although containing no instructions for the production of a protein, modulates the action of an important gene in the process of apoptosis, or programmed cell death.

31 Jul 2014

Researchers discover new function of body's most important tumor-suppressing protein

Researchers at Cold Spring Harbor Laboratory (CSHL) have discovered a new function of the body's most important tumor-suppressing protein. Called p53, this protein has been called "the guardian of the genome."

30 Jul 2014

CCC study provides hope that SapC-DOPS could be used for metastatic brain cancer treatment

Over half of patients being seen in the clinic for a diagnosed brain tumor have metastatic cancer, which has no treatment and detrimental outcomes in most cases.

25 Jul 2014

Cell Death News and Research

Findings may help develop biomarkers to identify HIV patients at risk of dementia

Factor in cells of naked mole rats protects activity of proteasome

Freiburg biochemists discover new mechanisms of brain disease

Researchers find more selective therapies for cancer

Finding suggests that retina acts as type of window to the brain

Researchers examine impact of BIM deletion on survival outcomes of advanced NSCLC patients

Insulin can protect cells of pancreas from acute pancreatitis

Choroidal consequences differ between anti-VEGF therapies

Scientists suggest that type-1 and type-2 diabetes are result of same mechanism

Research validates Myc inhibition as effective therapeutic strategy for glioma

MGH-developed microfluidic device may help study key steps involved in development of tumor metastasis

Study suggests autophagy is involved in the onset of vascular dementia

Researchers create synthetic ion transporter that triggers apoptosis in cancer cells

New drug spurs liver regeneration after surgery

Researchers discover how arginine starvation specifically kills cancer cells

Researchers create synthetic molecule that can cause cancer cells to self-destruct

Researchers find promising technique for type 1 diabetics to restore insulin producing cells

Researchers identify RNA that modulates action of important gene in process of programmed cell death

Researchers discover new function of body's most important tumor-suppressing protein

CCC study provides hope that SapC-DOPS could be used for metastatic brain cancer treatment

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