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BWH researchers use specific microRNA to identify, alter makeup of glioblastoma subtypes

Glioblastoma multiforme (GBM), an extremely aggressive brain cancer, is a very complex disease. It is characterized by a fast-growing tumor in the brain composed of many subpopulations of cells, including glioblastoma stem cells, which play a crucial role in glioblastoma initiation, expansion and therapy-resistance.

14 Jul 2017

FDA panel recommends new breakthrough gene therapy for B-cell acute lymphoblastic leukemia (ALL)

A Food and Drug Administration (FDA) panel created history by recommending a gene therapy for patients with cancer. In this therapy the patient’s own genes would be modified to fight the cancer cells. The patient’s cells which are thus altered to treat the cancer would thus be termed as “living drugs” as they act as soldiers to treat the cancer. These cells boost up the immune system and help the body fight the cancer.

14 Jul 2017

Cellular antennae play key role in muscle-to-fat transformation

Like it or not, as we age, our muscle cells are slowly exchanged, one by one, for fat cells. This process quickens when we injure a muscle, and an extreme form of this process is also seen in muscle-wasting diseases such as Duchenne muscular dystrophy (DMD).

13 Jul 2017

Cancer metastases may originate from primary tumor without involving lymph system

Research by several leading scientists including Rakesh Jain, PhD, Director of the Edwin L. Steele Laboratory for Tumor Biology at the Massachusetts General Hospital and supported in part by the National Foundation for Cancer Research, has provided the first evidence that the century-old model for cancer metastasis - where cancer spreads from primary tumor to nearby lymph nodes, and then to other organs - may not apply in all cases.

13 Jul 2017

Ground-breaking new breast cancer drugs have manageable toxicity profile for most patients

A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most patients.

13 Jul 2017

Potential vaccines could protect developing fetus from Zika virus, UTMB study shows

Immunizing female mice with a Zika vaccine can protect their developing fetus from infection and birth defects during pregnancy, according to new research from The University of Texas Medical Branch at Galveston.

13 Jul 2017

Scientists positively influence immune response in viral and bacterial co-infection

Researchers from Charité - Universitätsmedizin Berlin were able to positively influence the immune response in severe viral and bacterial co-infection.

13 Jul 2017

Experts develop first freely available data network for Huntington's disease research

Huntington's disease is a hereditary disorder of the nervous system caused by a faulty gene on chromosome four.

13 Jul 2017

Targeting immune cells could lead to new treatments for pulmonary fibrosis

Northwestern Medicine scientists have demonstrated that a unique population of immune cells plays a key role in the development of pulmonary fibrosis, and showed that targeting such cells could lead to new treatments for the disease.

13 Jul 2017

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia.

13 Jul 2017

Antimicrobial peptide packaged in silicon nanoparticle could combat drug-resistant bacteria

Antibiotic resistance is a growing problem, especially among a type of bacteria that are classified as "Gram-negative." These bacteria have two cell membranes, making it more difficult for drugs to penetrate and kill the cells.

13 Jul 2017

FDA advisory committee recommends Novartis' CAR-T therapy for young leukemia patients

Today the FDA's Oncologic Drugs Advisory Committee, an independent panel of experts, voted unanimously to recommend to the FDA approval of Novartis' experimental CAR-T therapy called Tisagenlecleucel, also known as CTL019.

13 Jul 2017

MPFI researchers reveal new technique to probe function of cerebellar interneurons

The cerebellum is an area of brain at the back of your head involved in movement. Its neuronal circuitry is relatively simple compared to other areas, but scientists still have a lot left to learn regarding its role in motor control and motor learning.

13 Jul 2017

Bone metastasis-targeting drug shows potential as new therapeutic strategy for osteosarcoma

The treatment of osteosarcoma, the most common tumor of bone, is challenging. A study led by The University of Texas MD Anderson Cancer Center found a drug known as bone metastasis-targeting peptidomimetic (BMTP-11) has potential as a new therapeutic strategy for this devastating illness.

13 Jul 2017

B Cell News and Research

BWH researchers use specific microRNA to identify, alter makeup of glioblastoma subtypes

FDA panel recommends new breakthrough gene therapy for B-cell acute lymphoblastic leukemia (ALL)

Cellular antennae play key role in muscle-to-fat transformation

Cancer metastases may originate from primary tumor without involving lymph system

Ground-breaking new breast cancer drugs have manageable toxicity profile for most patients

Potential vaccines could protect developing fetus from Zika virus, UTMB study shows

Scientists positively influence immune response in viral and bacterial co-infection

Experts develop first freely available data network for Huntington's disease research

Targeting immune cells could lead to new treatments for pulmonary fibrosis

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Antimicrobial peptide packaged in silicon nanoparticle could combat drug-resistant bacteria

FDA advisory committee recommends Novartis' CAR-T therapy for young leukemia patients

MPFI researchers reveal new technique to probe function of cerebellar interneurons

Bone metastasis-targeting drug shows potential as new therapeutic strategy for osteosarcoma

Newly identified biomarker panel could pave way to earlier detection of pancreatic cancer

Diabetes-induced changes in oral microbiome promote periodontal bone loss

Targeting acid metabolite reduces size and spread of breast cancer

Computational analysis of open-access data points to new ways of using drugs

Chemicals in house dust could promote accumulation of triglycerides and fat cells

Optical clearing technique reveals fine structure of the heart

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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