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Influenza vaccine effectiveness during the 2021–2022 influenza season in the United States

Researchers estimated influenza VE in patients aged ≥6 months seeking outpatient care for ARI due to the influenza A(H3N2) virus between October 2021 and April 2022 in the United States (US).

15 Dec 2022

Scientists uncover how FoxH1 factor binds to specific points in the genome

Transcription factors are proteins that interact with DNA to regulate the function of some genes. Generally, a single transcription factor binds to several regions in the genome as it orchestrates complex cellular responses, which require the activation or inhibition of several genes.

15 Dec 2022

Study reveals limited effects of longevity treatments on the aging process

Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.

14 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

Severity of COVID-19 in men may be due to the loss of Y chromosome

Men are at an increased risk of a severe bout of COVID-19 compared to women. Researchers at Uppsala University have now shown that this may be due to loss of the Y chromosome in part of their white blood cells.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

Scientists have developed a set of siRNAs against SARS-CoV-2 using computational approaches.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

NIH's All of Us Research Program begins returning personalized health-related DNA results to participants

The National Institutes of Health's All of Us Research Program has begun returning personalized health-related DNA results to more than 155,000 participants, with reports detailing whether participants have an increased risk for specific health conditions and how their body might process certain medications.

13 Dec 2022

Overview of current methods, technologies, and applications in the molecular diagnosis of mpox

Researchers provided an overview of existing molecular methods for mpox virus detection.

13 Dec 2022

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Huntington's disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function.

12 Dec 2022

New computer model can help researchers to spot which cells acquire alterations during development

Scientists at Johns Hopkins Medicine say they have developed a computer model - dubbed quantitative fate mapping - that looks back in the developmental timeline to trace the origin of cells in a fully grown organism

12 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Many genetic disorders respond well to specialized gene therapy

When the normal DNA sequence in an individual changes or mutates it can cause disease. The mutation may involve multiple genes and may be caused by environmental factors, or there may be chromosomal defects that are harmful at birth, in infancy or environment at a later stage.

12 Dec 2022

Genome News and Research

Influenza vaccine effectiveness during the 2021–2022 influenza season in the United States

Scientists uncover how FoxH1 factor binds to specific points in the genome

Study reveals limited effects of longevity treatments on the aging process

Research reveals that a viral toxin may contribute to the severity of COVID-19

Severity of COVID-19 in men may be due to the loss of Y chromosome

Study finds a novel therapeutic target for prevention and treatment of gout

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

NIH's All of Us Research Program begins returning personalized health-related DNA results to participants

Overview of current methods, technologies, and applications in the molecular diagnosis of mpox

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

New computer model can help researchers to spot which cells acquire alterations during development

Scientists use single-cell multi-omics data to map disease regulatory circuits

How human cell atlases provide the missing links between genes, diseases and therapies

Many genetic disorders respond well to specialized gene therapy

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

Reports of Mpox disease following recent vaccination

Severe COVID-19 causes aging-like changes in the human brain

Researchers design novel compounds with potential as drug treatments for COVID-19

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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