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Mutations identified that enable human transmission of avian flu

A systematic mutation analysis has shown that changes in just three amino acids of the avian influenza H7N9 virus receptor binding protein confers specificity for human cells.

16 Jun 2017

Nagoya University research identifies skin disease inherited as germline mutation from father

Nagoya University research identified a patient with the whole-body skin disease epidermolytic ichthyosis that had been inherited as a germline mutation from her father with the milder epidermolytic nevus.

16 Jun 2017

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.

16 Jun 2017

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Certain pediatric leukemias share a common underlying cause with treatment-related secondary leukemias.

16 Jun 2017

Penn scientists develop computer model that better simulates how cells spread in fibrous environments

One area of research within mechanobiology, the study of how physical forces influence biological processes, is on the interplay between cells and their environment and how it impacts their ability to grow and spread.

16 Jun 2017

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) - a newly recognized level of gene expression regulation - in bacterial keratitis – an infection of the cornea caused by bacteria - as well as to identify new therapeutic targets and alternative treatment strategies.

15 Jun 2017

Penn State scientists win grant to develop novel approach to contraception

Two Penn State researchers have received a grant through the Grand Challenges Explorations program -- an initiative funded by the Bill & Melinda Gates Foundation -- to develop a novel approach to contraception.

15 Jun 2017

Targeting regulatory T cells could be effective approach to treating cancers, research shows

Researchers at University of Pittsburgh School of Medicine and UPMC have discovered a clue that could unlock the potential of immunotherapy drugs to successfully treat more cancers.

15 Jun 2017

Biomedical engineering professor wins $2 million grant for concussion research

Barclay Morrison, professor of biomedical engineering at Columbia Engineering, has won a $2 million five-year grant from the Paul G. Allen Family Foundation to study the underlying mechanisms of concussion.

15 Jun 2017

Blocking newly discovered cellular pathway could help control tumor growth

Scientists have discovered a new cellular pathway that can promote and support the growth of cancer cells. In a mouse model of melanoma, blocking this pathway resulted in reduction of tumor growth.

15 Jun 2017

Investigation evaluates new drug in microgravity to activate immune system, help combat cancer

On Earth, research into antibody-drug conjugates to treat cancer has been around a while. The research presents a problem, though, because Earth-based laboratories aren't able to mimic the shape of the cancer cell within the body, which can sometimes produce incorrect findings.

15 Jun 2017

Researchers recapitulate pathological condition of retinal diseases on a chip

Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL).

15 Jun 2017

Stem cell therapy may harm heart disease patients, study finds

Patients with severe and end-stage heart failure have few treatment options available to them apart from transplants and "miraculous" stem cell therapy.

15 Jun 2017

Research suggests how malformed proteins linked to Parkinson’s could spread from the gut to the brain

Recent research on Parkinson's disease has focused on the gut-brain connection, examining patients' gut bacteria, and even how severing the vagus nerve connecting the stomach and brain might protect some people from the debilitating disease.

15 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

JHH Nutrition Score can help quickly identify heart surgery patients at risk for malnutrition

Patients who are at risk for malnutrition when undergoing heart surgery now can be more quickly and easily identified, leading to intervention and potentially better surgical outcomes, according to a study published online today in The Annals of Thoracic Surgery.

15 Jun 2017

New TSRI study could have implications for development of flu vaccines, drug therapies

Scientists at The Scripps Research Institute have shown that for the virus that causes the flu, two wrongs can sometimes make a right.

15 Jun 2017

Research details how lymphoma cells acquire resistance to targeted therapy

Today some patients suffering with mantle cell lymphoma, a type of blood cancer, can be treated with a pill called Ibrutinib, forgoing conventional chemotherapy. However, many are developing a resistance to this treatment.

15 Jun 2017

Hidden immune cells play key role in driving primary graft dysfunction

Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation.

15 Jun 2017

Penn study reveals new molecular pilot light required to turn on brown fat furnace

As we bask in the summer heat, it is easy to take for granted that humans are also prepared for the cold of winter, with overcoats in the closet and home heating systems ready to be fired up as an added assurance against falling temperatures.

15 Jun 2017

B Cell News and Research

Mutations identified that enable human transmission of avian flu

Nagoya University research identifies skin disease inherited as germline mutation from father

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Penn scientists develop computer model that better simulates how cells spread in fibrous environments

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Penn State scientists win grant to develop novel approach to contraception

Targeting regulatory T cells could be effective approach to treating cancers, research shows

Biomedical engineering professor wins $2 million grant for concussion research

Blocking newly discovered cellular pathway could help control tumor growth

Investigation evaluates new drug in microgravity to activate immune system, help combat cancer

Researchers recapitulate pathological condition of retinal diseases on a chip

Stem cell therapy may harm heart disease patients, study finds

Research suggests how malformed proteins linked to Parkinson’s could spread from the gut to the brain

Researchers bioengineer human liver tissues that mimic natural development

JHH Nutrition Score can help quickly identify heart surgery patients at risk for malnutrition

New TSRI study could have implications for development of flu vaccines, drug therapies

Research details how lymphoma cells acquire resistance to targeted therapy

Hidden immune cells play key role in driving primary graft dysfunction

Penn study reveals new molecular pilot light required to turn on brown fat furnace

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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