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Study shows that even breast cancers with few androgen receptors benefit from anti-androgen therapy

A University of Colorado Cancer Center study published today in the journal Molecular Cancer Therapeutics shows that only about 1 percent of triple-negative breast cancer cells in a tumor must be "androgen-receptor-positive" to show benefit from anti-androgen therapies.

25 Feb 2015

Johns Hopkins scientists identify genetic pathway that may spur cancer cell growth in children

Working with cells taken from children with a very rare but ferocious form of brain cancer, Johns Hopkins Kimmel Cancer Center scientists have identified a genetic pathway that acts as a master regulator of thousands of other genes and may spur cancer cell growth and resistance to anticancer treatment.

24 Feb 2015

Rigel, Bristol-Myers Squibb partner to develop, commercialize TGF beta receptor kinase inhibitors

Rigel Pharmaceuticals, Inc. and Bristol-Myers Squibb Company today announced that they have entered into a collaboration agreement for the discovery, development and commercialization of cancer immunotherapies based on Rigel's extensive portfolio of small molecule TGF beta receptor kinase inhibitors.

23 Feb 2015

Researchers reveal new understanding of pathobiology behind vestibular schwannoma

Researchers from the Eaton-Peabody Laboratories of Massachusetts Eye and Ear and the Harvard Medical School/ Massachusetts Institute of Technology Program in Speech and Hearing Bioscience and Technology have revealed new understanding of the pathobiology behind a head and neck tumor that may someday lead to new methods of targeted drug therapy.

21 Feb 2015

Researchers demonstrate clinical efficacy of gallopamil in severe asthma patients

A team of Inserm researchers from the Cardio-Thoracic Research Centre of Bordeaux (Inserm/University of Bordeaux and Bordeaux University Hospital) has demonstrated the clinical efficacy of gallopamil in 31 patients with severe asthma. This chronic disease is characterised by remodelling of the bronchi, which exacerbates the obstruction of the airways already seen in "classic" asthma.

20 Feb 2015

Study results pave way for new clinical trial for glioblastoma patients

Immune cells engineered to seek out and attack a type of deadly brain cancer were found to be both safe and effective at controlling tumor growth in mice that were treated with these modified cells, according to a study published in Science Translational Medicine by a team from the Perelman School of Medicine at the University of Pennsylvania and the Novartis Institutes for BioMedical Research.

19 Feb 2015

Research findings could someday lead to new treatments for patients with autism and cancer

In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in the ACS journal Biochemistry that the defects reduce the activity and stability of the protein.

19 Feb 2015

Research finds that mtDNA can move from healthy cell to dysfunctional tumour cell

Ground-breaking research from Griffith University on the Gold Coast has some scientists wondering if the entire study of cellular biology needs to be adjusted.

11 Feb 2015

UNC researchers create new research tool to help crack the histone code

University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

11 Feb 2015

Griffith research unlocks more about cancer

A research collaboration between Griffith and the Malaghan Institute in Wellington, New Zealand has made the discovery that mitochondria are capable of passing through the healthy membrane of a host cell into defective tumour cells, possibly kicking off the rapid proliferation of tumour cells which is the hallmark of cancer.

10 Feb 2015

Combination therapies may overcome resistance to targeted cancer drugs

A protein called YAP, which drives the growth of organs during development and regulates their size in adulthood, plays a key role in the emergence of resistance to targeted cancer therapies, according to a new study led by UC San Francisco researchers.

10 Feb 2015

Salicylates drugs reduce proliferation, viability of cultured vestibular schwannoma cells

Researchers from Massachusetts Eye and Ear and the Harvard Medical School/ Massachusetts Institute of Technology's Program in Speech and Hearing Bioscience and Technology have demonstrated that salicylates, a class of non-steroidal inflammatory drugs (NSAIDs), reduced the proliferation and viability of cultured vestibular schwannoma cells that cause a sometimes lethal intracranial tumor that typically causes hearing loss and tinnitus.

9 Feb 2015

New study provides better understanding of how stem cells give rise to tumors

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers.

6 Feb 2015

Dartmouth scientists discover novel cancer resistance mechanism

In the search for new approaches to treat ERBB2 (also known as HER2) positive breast cancers that have become drug-resistant, Dartmouth's Norris Cotton Cancer Center investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism with findings published in Cell Cycle.

3 Feb 2015

Johns Hopkins pediatricians offer guidelines on choosing between urgent care and ER

Parents have a natural tendency to fear the worst when it comes to their children and often opt for a "better safe than sorry" course of action, Canares says, but the truth is many situations don't warrant a trip to the emergency room. At the other end of the spectrum are cases that clearly require emergency attention but end up in urgent care instead — a less common scenario, Canares says.

2 Feb 2015

Mathematical models of cancer behavior offer new insights on tumor growth

Hassan Fathallah-Shaykh, M.D., Ph.D., believes that math can transform medicine, and he has the numbers to prove it.

2 Feb 2015

Study provides common model of cellular ageing

Researchers at the BBSRC-supported Babraham Institute have mapped the physical structure of the nuclear landscape in unprecedented detail to understand changes in genomic interactions occurring in cell senescence and ageing. Their findings have allowed them to reconcile the contradictory observations of two current models of ageing: cellular senescence of connective tissue cells called fibroblasts and cellular models of an accelerated ageing syndrome.

2 Feb 2015

Researchers gain new insight on immune cells that harbor latent HIV virus

Drugs for HIV have become adept at suppressing infection, but they still can't eliminate it. That's because the medication in these pills doesn't touch the virus' hidden reserves, which lie dormant within infected white blood cells. Unlock the secrets of this pool of latent virus, scientists believe, and it may become possible to cure - not just control - HIV.

2 Feb 2015

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 (SIRT1) protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

31 Jan 2015

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country.

31 Jan 2015

Proliferation News and Research

Study shows that even breast cancers with few androgen receptors benefit from anti-androgen therapy

Johns Hopkins scientists identify genetic pathway that may spur cancer cell growth in children

Rigel, Bristol-Myers Squibb partner to develop, commercialize TGF beta receptor kinase inhibitors

Researchers reveal new understanding of pathobiology behind vestibular schwannoma

Researchers demonstrate clinical efficacy of gallopamil in severe asthma patients

Study results pave way for new clinical trial for glioblastoma patients

Research findings could someday lead to new treatments for patients with autism and cancer

Research finds that mtDNA can move from healthy cell to dysfunctional tumour cell

UNC researchers create new research tool to help crack the histone code

Griffith research unlocks more about cancer

Combination therapies may overcome resistance to targeted cancer drugs

Salicylates drugs reduce proliferation, viability of cultured vestibular schwannoma cells

New study provides better understanding of how stem cells give rise to tumors

Dartmouth scientists discover novel cancer resistance mechanism

Johns Hopkins pediatricians offer guidelines on choosing between urgent care and ER

Mathematical models of cancer behavior offer new insights on tumor growth

Study provides common model of cellular ageing

Researchers gain new insight on immune cells that harbor latent HIV virus

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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