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Study prompts further assessment of tomato extracts’ use in gastric cancer prevention

A new study shows that whole tomato extracts from two different Southern Italy cultivars inhibit gastric cancer cell growth and malignant features, paving the way for future studies aimed at implementing lifestyle habits not only for prevention but potentially as a support to conventional therapies.

15 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Boosting a part of the immune system known to have anti-tumor properties may actually help tumors grow in cancers linked to chronic inflammation.

12 May 2017

Analyzing single-cell RNA data in pre-malignant tumors

RNA sequencing is basically the isolation of RNA from cells and the use of reverse transcriptase to turn the RNA into DNA. You can then use your standard DNA sequencing technologies to quantify the cDNA that you obtained from the reverse transcription reaction.

12 May 2017

Mayo Clinic research advances understanding of DNA repair mechanisms

We humans like to think our DNA is well-protected in the nucleus of each cell. But it's a hard life for the hard-working genetic code.

12 May 2017

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Tumors, inflammation and circulatory disorders locally disturb the body's acid-base balance. These changes in pH value could be used for example to verify the success of cancer treatments.

12 May 2017

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.

12 May 2017

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

HSV1716 – an oncolytic herpes simplex virus-1 – has been studied in adults via injection into the brain and superficial tumors.

11 May 2017

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy.

11 May 2017

Study reveals how proline metabolism supports breast cancer metastasis

A multinational group of scientists, led by professor Sarah-Maria Fendt, have discovered that breast cancer cells that have invaded other organs rely on a different nutrient metabolism to produce energy than normal cells and non-metastasizing cancer cells.

11 May 2017

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues. Researchers at Ludwig-Maximilians-Universitaet in Munich led by Professor Heiko Hermeking have now uncovered the molecular mechanism that links the two phenomena.

11 May 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

New research published online in The FASEB Journal suggests that the suppression of thyroid hormone receptor activity locally in the retina protects cone photoreceptor cells in mouse models of human retinal degenerative diseases

11 May 2017

Introduction of ART has increased life expectancy in HIV patients by 10 years

A study published in the journal The Lancet HIV has found an increase in life expectancy of 20-year-old HIV patients in the EU and North America who had started antiretroviral therapy (ART) after it was introduced mid-1990s. When compared with patients who were not treated with ART, the life expectancy had increased by around a decade in these patients.

11 May 2017

New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions

In 2013 researchers led by IMBA scientist Jürgen Knoblich flabbergasted the scientific community. Starting from human stem cells, researchers in his lab managed to grow living three dimensional models of basic units of human brain in a dish.

11 May 2017

Chemical stimuli by small molecule can improve production of cartilage cells

Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.

11 May 2017

Scientists identify unusual mutations in endometriosis using gene sequencing tools

Using gene sequencing tools, scientists from Johns Hopkins Medicine and the University of British Columbia have found a set of genetic mutations in samples from 24 women with benign endometriosis, a painful disorder marked by the growth of uterine tissue outside of the womb.

11 May 2017

B Cell News and Research

Study prompts further assessment of tomato extracts’ use in gastric cancer prevention

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Analyzing single-cell RNA data in pre-malignant tumors

Mayo Clinic research advances understanding of DNA repair mechanisms

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Study reveals how proline metabolism supports breast cancer metastasis

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

CUMC researchers create new organoids that mimic features of full-sized lung

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

Introduction of ART has increased life expectancy in HIV patients by 10 years

New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions

Chemical stimuli by small molecule can improve production of cartilage cells

Scientists identify unusual mutations in endometriosis using gene sequencing tools

New technology could hold key to predicting outcome of blood cancer patients

Researchers identify cells that drive autoimmune disease

Scientists discover natural defense mechanism that kills TB bacteria

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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