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Researchers uncover unexpected mechanism of glucose sensing in skeletal muscles

It's obvious that the taste buds on the tongue can detect sugar. And after a meal, beta cells in the pancreas sense rising blood glucose and release the hormone insulin - which helps the sugar enter cells, where it can be used by the body for energy.

5 May 2017

New research identifies immunotherapy targets to offer hope for early-stage lung cancer patients

Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance to take hold and offering a potential cure, according to a new Mount Sinai study published today in Cell.

4 May 2017

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia.

4 May 2017

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

Columbia University Medical Center researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy.

4 May 2017

GW scientist awarded $1.7 million grant to understand mechanisms behind Hedgehog receptor

Among scientists specializing in the area, the mechanisms behind the signaling function of the Hedgehog (Hh) receptor pathway remain a mystery. Xiaoyen Zheng, Ph.D., assistant professor of anatomy and regenerative biology at the George Washington University School of Medicine and Health Sciences, who recently received a $1.7 million grant from the National Institutes of Health and National Institute of General Medical Sciences, is determined to learn more about the Hh pathway.

4 May 2017

New synthetic retina could offer new hope to visually impaired people

A synthetic, soft tissue retina developed by an Oxford University student could offer fresh hope to visually impaired people.

4 May 2017

Researchers develop hybrid nanomaterial for destruction of cancer cells

Most tumors contain regions of low oxygen concentration where cancer therapies based on the action of reactive oxygen species are ineffective.

4 May 2017

Researchers identify biomarker that could predict disease severity in glaucoma patients

Glaucoma, a leading cause of blindness worldwide, most often is diagnosed during a routine eye exam. Over time, elevated pressure inside the eye damages the optic nerve, leading to vision loss. Unfortunately, there's no way to accurately predict which patients might lose vision most rapidly.

4 May 2017

$New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds$

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

A team of researchers of the University of Barcelona and the Hospital del Mar Medical Research Institute have discovered a new mutation that has an impact on the bone so that it is vulnerable to the bisphosphonate, a drug used to treat osteoporosis.

4 May 2017

New drug mimics health effects of exercise, say researchers

Scientists have managed to mimic the health effects of exercise in mice, simply by using a pill, according to a study published in Cell Metabolism. The drug activated a genetic pathway that is triggered by running, which led mice to burn off more fat and increase their stamina levels, despite them being sedentary.

4 May 2017

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

A new study published in the journal Molecular Therapy reveals that HIV DNA in the genome of living animals can be removed to eliminate further infection. While a permanent cure for infection caused by HIV remains a challenge due to the ability of the virus to hide away in latent reservoirs. The study team comprising Wenhui Hu, Kamel Khalili, Laura H. Carnell, and Won-Bin Young carried out an experiment on three different animal models.

4 May 2017

Scientists identify how key skin barrier protein drives development of eczema

Scientists have uncovered evidence that a deficiency in the skin's barrier is key to triggering eczema. The team at Newcastle University, in collaboration with scientists at Stiefel, a GSK company, have identified how a key skin barrier protein called filaggrin impacts on other proteins and pathways in the skin, which in turn drive the development of eczema.

4 May 2017

Synthetic biologists re-engineer yeast cells to manufacture antibiotic penicillin

The synthetic biologists from Imperial College London have re-engineered yeast cells to manufacture the nonribosomal peptide antibiotic penicillin. In laboratory experiments, they were able to demonstrate that this yeast had antibacterial properties against streptococcus bacteria.

4 May 2017

New poster presented at ASCB shows power of Phasefocus’ Livecyte label-free cell analysis system

Phasefocus provides a range of products and services based on its proprietary Ptychographic Quantitative Phase Imaging technology to provide a wide range of analytical applications including label-free cell imaging and quantitative electron phase microscopy.

From Phase Focus Limited 4 May 2017

Lethal DNA re-replication may be used to attack cancer cells

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise to aberrant cells as those detected in many carcinomas.

4 May 2017

Phagocytosis educates the immune system

Phagocytosis is a biological mechanism whereby specialized cells ingest and degrade old, dead, or damaged cells to prevent tissue damage due to their accumulation.

4 May 2017

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

10x Genomics, a company focused on enabling the mastery of biology by accelerating genomic discovery, today announced publication of an article in the journal Nature of a collaborative research study with researchers at the Stanford University School of Medicine.

From 10x Genomics, Inc. 4 May 2017

New research uncovers role of mysterious molecule in skin cancer

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma.

3 May 2017

Detailed images reveal how regulatory proteins affect function of brain receptors

Scientists at Columbia University have obtained the first detailed images of interactions between the AMPA receptor and molecules that regulate chemical signaling in the brain.

3 May 2017

Lost function of genes impairs development of motor skills in maturing mice

Scientists report in Neuron the lost function of two genes prevents infant laboratory mice from developing motor skills as they mature into adults. Researchers also suggest in their study that people with certain motor development disabilities be tested to see if they have mutant forms of the same genes.

3 May 2017

B Cell News and Research

Researchers uncover unexpected mechanism of glucose sensing in skeletal muscles

New research identifies immunotherapy targets to offer hope for early-stage lung cancer patients

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

GW scientist awarded $1.7 million grant to understand mechanisms behind Hedgehog receptor

New synthetic retina could offer new hope to visually impaired people

Researchers develop hybrid nanomaterial for destruction of cancer cells

Researchers identify biomarker that could predict disease severity in glaucoma patients

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

New drug mimics health effects of exercise, say researchers

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

Scientists identify how key skin barrier protein drives development of eczema

Synthetic biologists re-engineer yeast cells to manufacture antibiotic penicillin

New poster presented at ASCB shows power of Phasefocus’ Livecyte label-free cell analysis system

Lethal DNA re-replication may be used to attack cancer cells

Phagocytosis educates the immune system

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

New research uncovers role of mysterious molecule in skin cancer

Detailed images reveal how regulatory proteins affect function of brain receptors

Lost function of genes impairs development of motor skills in maturing mice

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