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Improving tuberculosis (TB) diagnosis: an interview with Professor Madhukar Pai, MD, PhD

TB is an infectious disease caused by Mycobacterium tuberculosis. Nearly 9 million people develop TB every year, and TB kills nearly 1.4 million individuals each year. While the incidence of TB has steadily declined in the west, it remains a huge public health problem in many developing countries, with India having the highest burden.

15 Feb 2013

Researchers show how gene mutations shift and evolve over time in chronic lymphocytic leukemia

Tumors are not factories for the mass production of identical cancer cells, but are, in reality, patchworks of cells with different patterns of gene mutations. In a new study, researchers at Dana-Farber Cancer Institute and the Broad Institute show, more fully than ever before, how these mutations shift and evolve over time in chronic lymphocytic leukemia (CLL) - providing a strobe-like look at the genetic past, present, and future of CLL tumors.

15 Feb 2013

Dompé initiates enrollment in rhNGF phase I/II REPARO study for neurotrophic keratitis

The first patient has been enrolled in the phase I/II REPARO study, the first international clinical trial evaluating the ophthalmological use of a topical solution of recombinant human Nerve Growth Factor (rhNGF) for the treatment of moderate to severe neurotrophic keratitis (NK).

15 Feb 2013

Pivotal Response Treatment improves brain activity in children with autism

Using functional magnetic resonance imaging (fMRI) for before-and-after analysis, a team of researchers including a UC Santa Barbara graduate student discovered positive changes in brain activity in children with autism who received a particular type of behavioral therapy.

15 Feb 2013

Cardinal Health announces plans to acquire AssuraMed

Cardinal Health today announced plans to acquire privately held AssuraMed, a leading provider of medical supplies to patients in the home, for $2.07 billion, or $1.94 billion, net of the present value of tax benefits.

15 Feb 2013

ASGCT to honor UNC genetics professor with 2013 Outstanding New Investigator Award

Aravind Asokan, PhD, assistant professor of genetics in the University of North Carolina School of Medicine, was selected by the American Society of Gene and Cell Therapy to receive a 2013 Outstanding New Investigator Award.

15 Feb 2013

Elemental diet may help adults with eosinophilic esophagitis

Results from a small study suggest that consumption of an elemental diet for 2–4 weeks results in a significant histologic improvement in adult patients with eosinophilic esophagitis.

14 Feb 2013

US health system failing unaccompanied immigrant children

Unaccompanied immigrant or “alien” children arriving in the USA with no papers or family often receive no or inadequate mental healthcare, says the author of an article published in JAMA Pediatrics.

14 Feb 2013

Endovascular stroke therapy disappoints in head-to-head studies

Three randomized trials published in The New England Journal of Medicine have failed to prove that endovascular therapy results in better clinical outcomes than standard medical therapy in patients with acute ischemic stroke.

14 Feb 2013

Cortisol and white matter integrity relationship disrupted in bipolar disorder

Researchers have found evidence in support of hypercortisol-induced glial dysfunction affecting periventricular white matter integrity in patients with bipolar disorder.

14 Feb 2013

Nerve stimulation could stave off migraine attacks

Transcutaneous stimulation of the trigeminal nerve has shown promise as a treatment for migraine, according to results of a randomized controlled trial.

14 Feb 2013

Researchers ESTABLISH efficacy of tedizolid phosphate for skin infections

Results from the phase III ESTABLISH-1 study show that the new antibiotic tedizolid phosphate is noninferior to linezolid for the treatment of acute bacterial and skin structure infections.

14 Feb 2013

Long’s manipulation enhances massage for chronic neck pain

Long’s manipulation, a Chinese manipulation approach that incorporates spinal manipulation and traditional Chinese massage, appears to be more effective for treating chronic mechanical neck pain than massage alone, study findings show.

14 Feb 2013

Researcher to study ADAM12 gene in breast tumor initiating cells

A Kansas State University professor's research on breast cancer stem cells may help improve survival rates by preventing cancer recurrence and metastasis -- the major causes of death among breast cancer patients.

14 Feb 2013

Combination of Methotrexat and Tofacitinib shows promise against rheumatoid arthritis

Together with colleagues from the international rheumatic diseases research community, scientists of the Charité - Universitätsmedizin Berlin have presented a new therapy approach for the treatment of rheumatoid arthritis (RA), a chronic form of joint inflammation.

14 Feb 2013

FDA grants IDE approval to STS and ACC to study alternative access approaches for TAVR

The Society of Thoracic Surgeons (STS) and the American College of Cardiology (ACC) have received a unique investigational device exemption (IDE) from the U.S. Food and Drug Administration (FDA) to study "alternative access" approaches for transcatheter aortic valve replacement (TAVR) using the STS/ACC TVT Registry.

14 Feb 2013

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.

14 Feb 2013

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

An increasing number of bacteria is evolving antibiotic resistance. Much-feared representatives of this steadily growing group include Staphylococci strains. At this point, multi-resistant forms of the bacterium Staphylococcus aureus - the "hospital germ" known commonly by its acronym, MRSA - can only be treated with a select subset of antibiotics as many drugs have simply stopped working. This is precisely why the field of medicine is in desperate need of new treatment options.

14 Feb 2013

Will more availability of some Medicare therapies spark a budget crisis?

Politico looks at how making some therapies more widely available to Medicare recipients -- as one lawsuit is asking for -- could strain the program's budget. In addition, The Associated Press examines Medicare records to find that monitoring some kidney cancer patients instead of operating could improve their chances to live.

14 Feb 2013

Novel approach uses adult stem cells to save sight of diabetes sufferers

Scientists at Queen's University Belfast are hoping to develop a novel approach that could save the sight of millions of diabetes sufferers using adult stem cells.

14 Feb 2013

Therapy News and Research

Improving tuberculosis (TB) diagnosis: an interview with Professor Madhukar Pai, MD, PhD

Researchers show how gene mutations shift and evolve over time in chronic lymphocytic leukemia

Dompé initiates enrollment in rhNGF phase I/II REPARO study for neurotrophic keratitis

Pivotal Response Treatment improves brain activity in children with autism

Cardinal Health announces plans to acquire AssuraMed

ASGCT to honor UNC genetics professor with 2013 Outstanding New Investigator Award

Elemental diet may help adults with eosinophilic esophagitis

US health system failing unaccompanied immigrant children

Endovascular stroke therapy disappoints in head-to-head studies

Cortisol and white matter integrity relationship disrupted in bipolar disorder

Nerve stimulation could stave off migraine attacks

Researchers ESTABLISH efficacy of tedizolid phosphate for skin infections

Long’s manipulation enhances massage for chronic neck pain

Researcher to study ADAM12 gene in breast tumor initiating cells

Combination of Methotrexat and Tofacitinib shows promise against rheumatoid arthritis

FDA grants IDE approval to STS and ACC to study alternative access approaches for TAVR

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

Will more availability of some Medicare therapies spark a budget crisis?

Novel approach uses adult stem cells to save sight of diabetes sufferers

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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