Preclinical News and Research

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Study: Estrogen may reduce severity of COVID-19 symptoms in women

Why are men at greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age?

27 Aug 2020

Researchers discover mechanisms underlying learning and memory formation in the brain

Seeking an answer, researchers at CHU Sainte-Justine Hospital and Université de Montréal have made a major discovery in understanding the mechanisms underlying learning and memory formation.

26 Aug 2020

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

In May 2019, the U.S. Food and Drug Administration approved a gene replacement therapy for the inherited, progressive neuromuscular disease 5q-linked spinal muscular atrophy.

25 Aug 2020

Preclinical studies of a COVID-19 vaccine candidate show positive results

Preclinical studies of a COVID-19 vaccine candidate at the University of Alabama at Birmingham show positive results that appear to distinguish this vaccine candidate from other vaccine candidates that are currently in advanced stages of clinical development, the Maryland-based Altimmune Inc. announced today.

25 Aug 2020

Highly expressed protein in lung cancer cells drives resistance to targeted therapies

A protein highly expressed in lung cancer cells drives resistance to targeted therapies, report researchers at the Medical University of South Carolina in the Journal of Thoracic and Cardiovascular Surgery.

25 Aug 2020

Researchers identify potential drug target for curtailing cancer metastasis

Researchers led by Ludwig Chicago Co-director Ralph Weichselbaum and Ronald Rock of the University of Chicago have identified in preclinical studies a potential drug target for curtailing cancer metastasis.

24 Aug 2020

New cancer vaccine is predicted to be more effective in human trials

Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine more effective.

24 Aug 2020

AI can expedite drug repurposing process for finding COVID-19 therapies, says GlobalData

Out of all the different approaches available to find new therapies to treat COVID-19, drug repurposing is one of the fastest and safest methods, as the drugs are already being used to treat other conditions therefore leading to fewer chances of adverse reactions.

21 Aug 2020

Cobra Biologics successfully produced master cell banks for CombiGene’s gene therapy

Cobra Biologics, part of the Cognate BioServices family, an international CDMO manufacturer of biological materials and pharmaceuticals, and CombiGene AB, the leading gene therapy company in the Nordic region, today announced that Cobra has successfully produced master cell banks for the three plasmids used as starting material for CombiGene’s gene therapy CG01.

21 Aug 2020

Macaques show low neutralizing antibody and cellular immune response to SARS-CoV-2

A new study published on the preprint server bioRxiv* in August 2020 presents a cynomolgus macaque model that develops symptomatic SARS-CoV-2 infection in a mild form, with low or no antibody responses, making it suitable to study human responses to vaccines and drugs targeting the virus.

21 Aug 2020

HEARTROID PROJECT and TTDD lab at MIT partner to develop innovative devices

HEARTROID PROJECT and the TTDD lab at MIT today announced a creative partnership. HEARTROID platform, a catheter-based simulator, will participate in TTDD lab's effort of validating device performance with its pulsatile and anatomically precise 3D printed models, helping accelerate surgical device development from concept to testing.

19 Aug 2020

Pigs appear to be immune to SARS-CoV-2

Now, a team of researchers at Kansas State University aimed to determine if pigs are potential carriers of SARS-CoV-2, the virus that causes the coronavirus disease (COVID-19).

18 Aug 2020

Wits University begins South African trial of Novavax COVID-19 vaccine

NVX-CoV2373 is produced by the biotech company, Novavax (Maryland, U.S.A). Novavax is a late-stage biotechnology company that develops next-generation vaccines for serious infectious diseases.

17 Aug 2020

Study opens new therapeutic avenue for treating glioblastoma tumors

New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma.

17 Aug 2020

Potency-enhancing drugs show ability to improve prognosis in patients with colorectal cancer

A new study from Lund University and Region Skåne in Sweden indicates that potency-enhancing PDE5 inhibitor drugs have an anti-cancer potential with the ability to improve the prognosis in patients with colorectal cancer.

17 Aug 2020

Targeting SARS-CoV-2 with off-the-shelf CAR-NK cells

The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and cause disease and death in many countries even today. At present, there is no effective treatment. A recent study published on the preprint server bioRxiv in August 2020 reports the potential of a new class of drugs called CAR NK cells, which could be used off-the-shelf to treat this disease.

17 Aug 2020

U.S. scientists to create coronavirus strain for human challenge trials

Now, a team of scientists in the United States plans to create a coronavirus strain that can be used for human challenge trials, a controversial type of study wherein health volunteers would be vaccinated and intentionally infected with the virus.

16 Aug 2020

Gene variants help explain link between skin condition and food allergies

Two common variants in the KIF3A gene increase the risk of young children having a dysfunctional skin barrier and developing the skin condition atopic dermatitis.

14 Aug 2020

De novo designed SARS-CoV-2 nanoparticle vaccine

In light of the continuing threat to public health, social functioning, and economic activity posed by the COVID-19 pandemic, scientists are working urgently to bring out a vaccine that is both safe and effective, and capable of mass production. A new paper published on the preprint server bioRxiv* in August 2020 shows that such a vaccine may be produced by using arrays of one severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein on a nanoparticle platform.

14 Aug 2020

Radiation therapy delay for prostate cancer patients offers room for flexibility during the pandemic

For cancer patients receiving radiation treatment during a surge in COVID-19 cases, adhering to the stay-at-home orders of quarantine is not always an option.

13 Aug 2020

Preclinical News and Research

Study: Estrogen may reduce severity of COVID-19 symptoms in women

Researchers discover mechanisms underlying learning and memory formation in the brain

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

Preclinical studies of a COVID-19 vaccine candidate show positive results

Highly expressed protein in lung cancer cells drives resistance to targeted therapies

Researchers identify potential drug target for curtailing cancer metastasis

New cancer vaccine is predicted to be more effective in human trials

AI can expedite drug repurposing process for finding COVID-19 therapies, says GlobalData

Cobra Biologics successfully produced master cell banks for CombiGene’s gene therapy

Macaques show low neutralizing antibody and cellular immune response to SARS-CoV-2

HEARTROID PROJECT and TTDD lab at MIT partner to develop innovative devices

Pigs appear to be immune to SARS-CoV-2

Wits University begins South African trial of Novavax COVID-19 vaccine

Study opens new therapeutic avenue for treating glioblastoma tumors

Potency-enhancing drugs show ability to improve prognosis in patients with colorectal cancer

Targeting SARS-CoV-2 with off-the-shelf CAR-NK cells

U.S. scientists to create coronavirus strain for human challenge trials

Gene variants help explain link between skin condition and food allergies

De novo designed SARS-CoV-2 nanoparticle vaccine

Radiation therapy delay for prostate cancer patients offers room for flexibility during the pandemic

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